The bio-energetic theory of carcinogenesis

González, Michael J.; Miranda-Massari, Jorge R.; Duconge, Jorge; Riordan, Neil H; Ichim, Thomas E.; Quintero-Del-Rio, Ana I.; Ortiz, Norma

doi:10.1016/j.mehy.2012.06.015

Cited by 32 publications

(37 citation statements)

References 34 publications

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“…Furthermore, the degree of malignancy in these breast tumors was correlated directly with the degree of mitochondrial structural abnormality (51). The high glycolytic activity and lactate production seen in the most malignant tumors were also linked to the mitochondrial structural abnormalities seen in the tumors (91,98–102). In contrast to inherited mitochondriopathies, where glycolysis might not compensate completely for mitochondrial energy failure, fermentation energy appears capable of compensating completely for the respiratory insufficiency in tumor cells (18,103).…”

Section: Respiratory Insufficiency As the Origin Of Cancer And The ‘Wmentioning

confidence: 99%

Cancer as a metabolic disease: implications for novel therapeutics

et al. 2013

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Emerging evidence indicates that cancer is primarily a metabolic disease involving disturbances in energy production through respiration and fermentation. The genomic instability observed in tumor cells and all other recognized hallmarks of cancer are considered downstream epiphenomena of the initial disturbance of cellular energy metabolism. The disturbances in tumor cell energy metabolism can be linked to abnormalities in the structure and function of the mitochondria. When viewed as a mitochondrial metabolic disease, the evolutionary theory of Lamarck can better explain cancer progression than can the evolutionary theory of Darwin. Cancer growth and progression can be managed following a whole body transition from fermentable metabolites, primarily glucose and glutamine, to respiratory metabolites, primarily ketone bodies. As each individual is a unique metabolic entity, personalization of metabolic therapy as a broad-based cancer treatment strategy will require fine-tuning to match the therapy to an individual’s unique physiology.

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Section: Respiratory Insufficiency As the Origin Of Cancer And The ‘Wmentioning

confidence: 99%

Cancer as a metabolic disease: implications for novel therapeutics

et al. 2013

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show abstract

“…Furthermore, the degree of malignancy in these breast tumors was correlated directly with the degree of mitochondrial structural abnormality (51). The high glycolytic activity and lactate production seen in the most malignant tumors were also linked to the mitochondrial structural abnormalities seen in the tumors (91,(98)(99)(100)(101)(102). In contrast to inherited mitochondriopathies, where glycolysis might not compensate completely for mitochondrial energy failure, fermentation energy appears capable of compensating completely for the respiratory insufficiency in tumor cells (18,103).…”

Section: Respiratory Insufficiency As the Origin Of Cancer And The 'Wmentioning

confidence: 99%

Cancer as a Metabolic Disease: Implications for Novel Therapeutics

Seyfried¹

2013

AACR Education book

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“…Consequently, the required ATP is produced through anaerobic pathways [11]. The yield of the anaerobic synthesis of ATP is very low and leads to an increased glucose consumption rate [43].…”

Section: Discussionmentioning

confidence: 99%