The Bioactive Dietary Polyphenol Preparation Alleviates Depression and Anxiety‐Like Behaviors by Modulating the Regional Heterogeneity of Microglia Morphology

Yang, Eun-Jeong; Frolinger, Tal; Iqbal, Umar; Murrough, James W.; Pasinetti, Giulio Maria

doi:10.1002/mnfr.202300156

Cited by 3 publications

(1 citation statement)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the case of CS, if selected foods could be used as a preventive measure to alleviate CS-related symptoms including depression, it would provide adolescents with safer health protection. Recent studies have revealed that some food-based active ingredients, such as polysaccharides, oligosaccharides, polyphenols and unsaturated fatty acids, have specific regulatory effects on some chronic stress-related health issues [ 13 , 14 , 15 , 16 , 17 ]. However, there is a lack of research on interventions for physiological and psychological function impairment in animals or humans experiencing CS during their growth period, which limits the development of products to improve CS.…”

Section: Introductionmentioning

confidence: 99%

Microbiome and Metabolite Analysis Insight into the Potential of Shrimp Head Hydrolysate to Alleviate Depression-like Behaviour in Growth-Period Mice Exposed to Chronic Stress

Hu,

Ye,

Deng

et al. 2024

Nutrients

View full text Add to dashboard Cite

Chronic stress (CS) endangers the physical and mental health of adolescents. Therefore, alleviating and preventing such negative health impacts are a top priority. This study explores the effect of feeding shrimp head hydrolysate (SHH) on gut microbiota, short-chain fatty acids (SCFAs), and neurotransmitters in growing C57BL/6 mice subjected to chronic unpredictable mild stress. Mice in the model group and three SHH groups were exposed to CS for 44 days, distilled water and SHH doses of 0.18, 0.45, 0.90 g/kg·BW were given respectively by gavage daily for 30 days from the 15th day. The results showed that SHH can significantly reverse depression-like behaviour, amino acids degradation, α diversity and β diversity, proportion of Firmicutes and Bacteroidota, abundance of genera such as Muribaculaceae, Bacteroides, Prevotellaceae_UCG-001, Parabacteroides and Alistipes, concentration of five short-chain fatty acids (SCFAs), 5-HT and glutamate induced by CS. Muribaculaceae and butyric acid may be a controlled target. This study highlights the potential and broad application of SHH as an active ingredient in food to combat chronic stress damage.

show abstract

Section: Introductionmentioning

confidence: 99%

Microbiome and Metabolite Analysis Insight into the Potential of Shrimp Head Hydrolysate to Alleviate Depression-like Behaviour in Growth-Period Mice Exposed to Chronic Stress

Hu,

Ye,

Deng

et al. 2024

Nutrients

View full text Add to dashboard Cite

show abstract

Unlocking Dietary Strategies to Combat Neurological Disorders

Soares Dias Portela,

Iban‐Arias,

Saxena

et al. 2024

Molecular Nutrition Food Res

View full text Add to dashboard Cite

The intricate interplay between diet and the gut-brain axis carries significant implications for the development and progression of neurodegenerative diseases. [1] Research indicates that dietary choices wield considerable influence over the composition and diversity of the gut microbiota, which, in turn, communicates bidirectionally with the brain via neural, endocrine, and immune pathways. [2] Perturbations in the gut microbiota have been implicated in the pathogenesis of neurodegenerative conditions like Alzheimer's disease (AD) and Parkinson's disease (PD), potentially exacerbating neuroinflammation, oxidative stress, and neuronal dysfunction. [3] Conversely, dietary interventions aimed at modulating the gut microbiota, such as the consumption of prebiotics, probiotics, and postbiotics, hold promise for mitigating disease processes and promoting brain health. [4] By fostering a balanced and diverse gut microbiome, these dietary approaches may help to alleviate neurodegenerative symptoms and even offer neuroprotective effects. As an example, polyphenols have been demonstrated to reverse and modulate inflammatory responses, as well reduction of free radicals, oxidative stress, impaired proteostasis, and cellular senescence, both in vitro and in vivo. [5][6][7] Pan et al. discussed in their review various available imaging methods and their potential for advancing our understanding of gut microbiota dynamics, aiming to lay the groundwork for future bio-intelligent imaging of intestinal bacteria. Ye et al. demonstrated that Stevioside mitigates prenatal obesity-induced cognitive and mood disorders (such as depression) via gut barrier restoration and inflammation inhibition in mice. Furthermore, in the innovative artificial intelligence (AI) scope, Soares Dias Portela et al. discussed how dietary factors have an impact in

show abstract

The role of gut microbiota and metabolomic pathways in modulating the efficacy of SSRIs for major depressive disorder

Jiang,

Qu,

Shi

et al. 2024

Transl Psychiatry

View full text Add to dashboard Cite

This study aims to explore the mechanism by which gut microbiota influences the antidepressant effects of serotonin reuptake inhibitors (SSRIs) through metabolic pathways. A total of 126 patients were analyzed for their gut microbiota and metabolomics. Patients received SSRI treatment and were categorized into responder and non-responder groups based on changes in their Hamilton Depression Rating Scale (HAMD-17) scores before and after treatment. The association between gut microbiota composition and the efficacy of SSRIs was investigated through 16S rRNA gene sequencing and metabolomic analysis, and a predictive model was developed. As a result, the study found significant differences in gut microbiota composition between the responder and resistant groups. Specific taxa, such as Ruminococcus, Bifidobacterium, and Faecalibacterium, were more abundant in the responder group. Functional analysis revealed upregulation of acetate degradation and neurotransmitter synthesis pathways in the responder group. The machine learning model indicated that gut microbiota and metabolites are potential biomarkers for predicting SSRIs efficacy. In conclusion, gut microbiota influences the antidepressant effects of SSRIs through metabolic pathways. The diversity and function of gut microbiota can serve as biomarkers for predicting the treatment response, providing new insights for personalized treatment.

show abstract

The Bioactive Dietary Polyphenol Preparation Alleviates Depression and Anxiety‐Like Behaviors by Modulating the Regional Heterogeneity of Microglia Morphology

Cited by 3 publications

References 45 publications

Microbiome and Metabolite Analysis Insight into the Potential of Shrimp Head Hydrolysate to Alleviate Depression-like Behaviour in Growth-Period Mice Exposed to Chronic Stress

Microbiome and Metabolite Analysis Insight into the Potential of Shrimp Head Hydrolysate to Alleviate Depression-like Behaviour in Growth-Period Mice Exposed to Chronic Stress

Unlocking Dietary Strategies to Combat Neurological Disorders

The role of gut microbiota and metabolomic pathways in modulating the efficacy of SSRIs for major depressive disorder

Contact Info

Product

Resources

About