The bioactivity and ion release of titanium-containing glass polyalkenoate cements for medical applications

Wren, A.W.; Cummins, Niamh M.; Laffir, Fathima; Hudson, Sarah P.; Towler, Mark R.

doi:10.1007/s10856-010-4184-4

Cited by 15 publications

(19 citation statements)

References 43 publications

(46 reference statements)

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“…They also showed that agitation (sample rotation at 1000 rounds per minute) or aging samples at higher temperature (70°C) significantly increases the ion release of Zn 2+ ions from the cement matrix into the medium, when compared to those aged at 37°C in static conditions. Wren et al [152] investigated titanium (Ti)-containing glasses and found that the immersion of GPCs based on such glasses into distilled water resulted in an increased surface area after 1 day which then decreased over the next 29 days of incubation. The increase in the surface area was attributed to the dissolution of PAA within the cement matrix (hydration processes) resulting in open porosity and thus liberating ions bound within the cement structure, which then sought anionic sites.…”

Section: Ion Releasementioning

confidence: 99%

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The role of poly(acrylic acid) in conventional glass polyalkenoate cements

Alhalawani

Curran

Boyd

et al. 2015

Journal of Polymer Engineering

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Abstract Glass polyalkenoate cements (GPCs) have been used in dentistry for over 40 years. These novel bioactive materials are the result of a reaction between a finely ground glass (base) and a polymer (acid), usually poly(acrylic acid) (PAA), in the presence of water. This article reviews the types of PAA used as reagents (including how they vary by molar mass, molecular weight, concentration, polydispersity and content) and the way that they control the properties of the conventional GPCs (CGPCs) formulated from them. The article also considers the effect of PAA on the clinical performance of CGPCs, including biocompatibility, rheological and mechanical properties, adhesion, ion release, acid erosion and clinical durability. The review has critically evaluated the literature and clarified the role that the polyacid component of CGPCs plays in setting and maturation. This review will lead to an improved understanding of the chemistry and properties of the PAA phase which will lead to further innovation in the glass-based cements field.

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Section: Ion Releasementioning

confidence: 99%

“…The release of ions was also influenced by the cross-linked PAA matrix. Studies [152,153] on Ti-containing glasses reported that there was no Ti 4+ release. Shen et al [153] showed that sodium was dissolved at higher rates than calcium and strontium.…”

Section: Ion Releasementioning

confidence: 99%

The role of poly(acrylic acid) in conventional glass polyalkenoate cements

Alhalawani

Curran

Boyd

et al. 2015

Journal of Polymer Engineering

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“…Previous work by the authors has seen the development of a SiO 2 -CaO-SrO-ZnO based GPC series for orthopaedics, in particular for stabilization of osteoporotic vertebral augmentation such as Vertebroplasty and Kyphoplasty [29][30][31][32]. Some properties of these materials, including mechanical and rheological properties and bioactivity were further improved by subsequently substituting titanium (Ti) for the silica content within the glass phase [33][34][35].…”

Section: Introductionmentioning

confidence: 99%

Gallium containing glass polyalkenoate anti-cancerous bone cements: glass characterization and physical properties

Wren

Coughlan

Placek

et al. 2012

J Mater Sci: Mater Med

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A gallium (Ga) glass series (0.48SiO(2)-0.40ZnO-0.12CaO, with 0.08 mol% substitution for ZnO) was developed to formulate a Ga-containing Glass Polyalkenoate Cement (GPC) series. Network connectivity (NC) and X-ray Photoelectron Spectroscopy (XPS) was employed to investigate the role of Ga(3+) in the glass, where it is assumed to act as a network modifier. Ga-GPC series was formulated with E9 and E11 polyacrylic acid (PAA) at 50, 55 and 60 wt% additions. E11 working times (T(w)) ranged from 68 to 96 s (Lcon.) and 106 s for the Ga-GPCs (LGa-1 and LGa-2). Setting times (T(s)) ranged from 104 to 226 s (Lcon.) and 211 s for LGa-1 and LGa-2. Compression (σc) and biaxial flexural (σf) testing were conducted where Lcon. increased from 62 to 68 MPa, LGa-1 from 14 to 42 MPa and LGa-2 from 20 to 47 MPa in σc over 1-30 days. σf testing revealed that Lcon. increased from 29 to 42 MPa, LGa-1 from 7 to 32 MPa and LGa-2 from 12 to 36 MPa over 1-30 days.

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“…Excessive oxygen in octahedral structures requires charge compensation, which may be one possible explanation for the of Ti release from these glasses. 35 Antibacterial testing was conducted for each glass, uncoated and Ag-coated using untreated glass (t ¼ 0) and also glass after 24 h immersion in sterile de-ionized H 2 O (ICP samples, t ¼ 24). Figure 9 presents the antibacterial properties of the uncoated glasses, control, AU-1, and AU-2.…”

Section: Resultsmentioning

confidence: 99%

Characterization and antibacterial efficacy of silver-coated Ca–Na–Zn–Si/Ti glasses

et al. 2011

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A glass series [xSiO₂[-y])·0.36ZnO·0.17Na₂O·0.05CaO (starting at x = 0.50, y = 0.08 TiO₂)] was formulated with TiO₂ substituting SiO₂. Each glass/silver-coated glass was characterized using X-ray diffraction, X-ray photoelectron spectroscopy (XPS), and scanning electron microscopy. Surface area analysis revealed significant changes after silver coating, 0.43-0.95 m²/g (control), to 0.53-1.85 m²/g (AU-1), and 0.20-1.11 m²/g (AU-2). Ion release from uncoated glasses included sodium (0.08 mg/L), calcium (0.07 mg/L), and zinc (0.008 mg/L), where silver-coated glasses presented 0.42 mg/L (silver), 0.33 mg/L (sodium), 0.02 mg/L (calcium), and 0.01 mg/L (zinc). Ag-coated glasses presented inhibition zones of 7.75 mm (control) compared to 1.04 mm (AU-2).

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The bioactivity and ion release of titanium-containing glass polyalkenoate cements for medical applications

Cited by 15 publications

References 43 publications

The role of poly(acrylic acid) in conventional glass polyalkenoate cements

The role of poly(acrylic acid) in conventional glass polyalkenoate cements

Gallium containing glass polyalkenoate anti-cancerous bone cements: glass characterization and physical properties

Characterization and antibacterial efficacy of silver-coated Ca–Na–Zn–Si/Ti glasses

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