The biochemical and histological effects of lichens in normal and diabetic rats

Deniz, Gulsah Yildiz; Geyikoğlu, Fatime; Türkez, Hasan; Bakır, Tülay Özhan; Çolak, Suat; Aslan, Ali

doi:10.1177/0748233713506769

Cited by 5 publications

(3 citation statements)

References 64 publications

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“…Previous studies 68 - 70 focused on possible anti-diabetic effects of Cetraria islandica and Pseudevernia furfuracea extracts in streptozotocin-induced diabetes in rats. Although investigators recommended low-dose C. islandica for early intervention in type 1 diabetes mellitus, the extracts did not improve diabetes-related parameters in rats.…”

Section: Pharmacological Activities Of Lichensmentioning

confidence: 99%

Lichens in Pharmacological Action: What Happened in the Last Decade?

Karagöz¹,

Karagoz²

2023

Eurasian J Med

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Lichens are a unique group of organisms, which can produce compounds that are named secondary metabolites and rarely or are not produced in other organisms. Lichens possess pharmacological actions related to their secondary metabolites. Our knowledge of lichens and their pharmacological actions rapidly increases as new technologies and devices, which facilitate the investigation of the chemical profile and biological activities of lichens, are introduced and become more readily available. In addition, new methods and perspectives, as well as suggestions for pharmacological mechanisms, accumulate daily. Furthermore, lichen substances stand as a relatively untapped source of natural products. Accordingly, researchers investigate the pharmacological actions of lichen-derived material more frequently than it was in the past. This review focused on the pharmacological activities of lichens published in the last 11 years (2012-2022). Literature data obtained from WebOfScience and PubMed databases using related search keywords revealed that anti-genotoxicity, anti-cancer, and anti-microbial activity studies have constantly been conducted. More recently, immunomodulatory and inflammation-related studies took to the stage. Enzyme inhibition actions were popular as well. Our selection was based on the novelty and mechanistic insight that papers presented.

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Section: Pharmacological Activities Of Lichensmentioning

confidence: 99%

Lichens in Pharmacological Action: What Happened in the Last Decade?

Karagöz¹,

Karagoz²

2023

Eurasian J Med

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“…Moreover, the aqueous extract of Cetraria islandica decreased the total oxidative stress (TOS) and increased the total antioxidant capacity (TAC) in streptozotocin-induced Diabetes Mellitus type 1 Sprague-Dawley rats [ 118 ]. Using the same model, the aqueous extract of Cetraria islandica (250–500 mg/kg/day) increased the levels of SOD, CAT and GSH, and reduced the levels of MDA [ 16 , 119 , 120 ]. Regarding neuroprotection studies, the protective role of Cetraria islandica and its isolated secondary metabolite fumarprotocetraric acid has been demonstrated in a hydrogen peroxide-induced oxidative stress model on human U373MG astrocytoma cells and human SH-SY5Y neuroblastoma cells.…”

Section: Therapeutic Potentialmentioning

confidence: 99%

The Genus Cetraria s. str.—A Review of Its Botany, Phytochemistry, Traditional Uses and Pharmacology

et al. 2022

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The genus Cetraria s. str. (Parmeliaceae family, Cetrarioid clade) consists of 15 species of mostly erect brown or greenish yellow fruticose or subfoliose thallus. These Cetraria species have a cosmopolitan distribution, being primarily located in the Northern Hemisphere, in North America and in the Eurasia area. Phytochemical analysis has demonstrated the presence of dibenzofuran derivatives (usnic acid), depsidones (fumarprotocetraric and protocetraric acids) and fatty acids (lichesterinic and protolichesterinic acids). The species of Cetraria, and more particularly Cetraria islandica, has been widely employed in folk medicine for the treatment of digestive and respiratory diseases as decoctions, tinctures, aqueous extract, and infusions. Moreover, Cetraria islandica has had an important nutritional and cosmetic value. These traditional uses have been validated in in vitro and in vivo pharmacological studies. Additionally, new therapeutic activities are being investigated, such as antioxidant, immunomodulatory, cytotoxic, genotoxic and antigenotoxic. Among all Cetraria species, the most investigated by far has been Cetraria islandica, followed by Cetraria pinastri and Cetraria aculeata. The aim of the current review is to update all the knowledge about the genus Cetraria covering aspects that include taxonomy and phylogeny, morphology and distribution, ecological and environmental interest, phytochemistry, traditional uses and pharmacological properties.

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“…98 In vitro studies on the effect of aqueous extracts of Cetraria islandica against diabetes-induced oxidative stress have revealed that this extract, at 5 and 10 mg mL À1 , increased antioxidant capacity in blood cultures of patients with diabetes; 99 however, no benecial effects on antioxidant status were found in diabetic rats treated intraperitoneally with 250-500 mg per kg per day of Cetraria islandica aqueous extract for 2 weeks. 100 In addition to C. islandica, the lichen specie Parmelia perlata afforded antidiabetic effect by stimulating insulin secretion. 92 Halici et al 70 demonstrated the potential gastroprotective effect of the aqueous extract of Usnea longissima against indomethacin-induced gastric lesions in rats through an antioxidant mechanism.…”

Section: Other Activitiesmentioning

confidence: 99%

Parmeliaceae family: phytochemistry, pharmacological potential and phylogenetic features

et al. 2014

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Parmeliaceae is the largest family of lichenized fungi comprising about 2700 species distributed in about 80 genera. A wide array of secondary metabolites including depsides, depsidones, aliphatic acids, triterpenes, anthraquinones, secalonic acids, pulvinic acid derivatives and xanthones have been identified within this family. Many of these bioactive compounds such as usnic acid and atranorin are exclusively found in this family, being of great relevance for the systematics and phylogeny. Moreover, these compounds exert different biological roles including antimicrobial, antioxidant, cytotoxic, anti-inflammatory, analgesic and enzyme inhibitory actions. The current review focuses on the phytochemistry and main phylogenetic aspects of Parmeliaceae, and it discusses the pharmacological findings and mechanisms of action of their extracts and isolated compounds. The present work actually collects information related to more than 65 lichen species (from 21 different genuses and heterogeneous distribution) and 75 isolated metabolites. As reported, the best studied genus from a pharmacological point of view is Parmelia, followed by Usnea. At the species level, Cetraria islandica and Evernia prunastri attract remarkable interest in their bioactive activities and metabolite content. The major pharmacological activities investigated on extracts and compounds from Parmeliaceae spp. have been antimicrobial, anticancer and antioxidant potentials; and regarding isolated compounds, the aforementioned usnic acid and atranorin are among the most studied metabolites. Reviewed data suggest that some of these lichens and natural compounds are worthy of further investigation.

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The biochemical and histological effects of lichens in normal and diabetic rats

Cited by 5 publications

References 64 publications

Lichens in Pharmacological Action: What Happened in the Last Decade?

Lichens in Pharmacological Action: What Happened in the Last Decade?

The Genus Cetraria s. str.—A Review of Its Botany, Phytochemistry, Traditional Uses and Pharmacology

Parmeliaceae family: phytochemistry, pharmacological potential and phylogenetic features

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