The Biochemical Properties of Carrier-Bound Methotrexate

Whiteley, John M.; Chu, Barbara C.F.; Galivan, John

doi:10.1007/978-1-4757-9510-3_18

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1984

1988

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“…Animal studies have been reported on the frog17 and cat17,18 for lc and le. In human studies, it has been reported that (8) Aboul-Enein, . N.; Bid, A. I. Acta Pharm.…”

Section: Pharmacology and Discussionmentioning

confidence: 99%

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Sulfur analogs of psychotomimetic agents. 30. Ethyl homologs of mescaline and their monothioanalogs

Jacob¹,

Shulgin²

1984

J. Med. Chem.

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All possible monothio analogues of the mono-, di-, and triethoxy homologues of mescaline have been synthesized and pharmacologically evaluated in man. Modifications at the ring position para to the ethylamine chain, either with a sulfur atom, a longer alkyl chain, or both, lead to compounds of high central nervous system activity. The 4-n-propoxy and 4-n-butoxy homologues and their corresponding 4-thio analogues were also synthesized and pharmacologically evaluated. The propyl homologues retain high potency, but a butyl group (either with or without a sulfur atom) leads to a decrease in activity. The m-ethyl or m-thio analogues retain some central action but the diethoxy and especially the triethoxy homologues are relatively inactive as psychotomimetic drugs.

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“…Animal studies have been reported on the frog17 and cat17,18 for lc and le. In human studies, it has been reported that (8) Aboul-Enein, . N.; Bid, A. I. Acta Pharm.…”

Section: Pharmacology and Discussionmentioning

confidence: 99%

“…(3,5-Diethoxy-4-methoxyphenyl)acetonitrile (8). To a solution of 2.1 g of the phenol 7c (9.5 mmol) in 20 mL of anhydrous acetone containing some 30 mg of phase-transfer catalyst [C10H21N(CH2CH3)3+r] there was added 2.0 mL of CH3I, followed by 2.3 g of pulverized anhydrous K2C03.…”

Section: Methodsmentioning

confidence: 99%