The biochemistry of compounds with anti-microtubule activity in plant cells

Morejohn, Louis C.; Fosket, Donald E.

doi:10.1016/0163-7258(91)90078-z

Cited by 112 publications

(52 citation statements)

References 119 publications

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“…Taxol promotes the polymerization of tubulin and thus stabilizes microtubules (Morejohn and Fosket, 1991;Bokros et al, 1993), and this causes radial swelling in Arabidopsis root tips despite cortical microtubules remaining transversely aligned (Baskin et al, 1994). We found that microfibrils in root epidermal cells treated with 10 M taxol, like those after prolonged oryzalin treatment, were locally parallel but variably oriented (see supplemental data online).…”

Section: Taxol Generates Radial Swelling and Arrests Cell Division Bmentioning

confidence: 99%

Mutation or Drug-Dependent Microtubule Disruption Causes Radial Swelling without Altering Parallel Cellulose Microfibril Deposition in Arabidopsis Root Cells[W]

et al. 2003

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As critical determinants of growth anisotropy in plants, cortical microtubules are thought to constrain the movement of cellulose synthase complexes and thus align newly deposited cellulose microfibrils. We tested this cellulose synthase constraint model using the temperature-sensitive mor1-1 mutant of Arabidopsis. Contrary to predictions, the disruption of cortical microtubules in mor1-1 root epidermal cells led to left-handed root twisting and radial swelling but did not alter the transverse orientation of cellulose microfibrils. We also found that drug-dependent disassembly or hyperstabilization of cortical microtubules did not alter the parallel order of cellulose microfibrils. By measuring cellulose content in mor1-1 seedlings, we verified that cellulose synthesis is not reduced at the restrictive temperature. The independence of cortical microtubule organization and cellulose microfibril alignment was supported by the observation that double mutants of mor1-1 and rsw1-1 , the cellulose-deficient mutant with misaligned microfibrils, had additive phenotypes. Our results suggest that cortical microtubules regulate growth anisotropy by some mechanism other than cellulose microfibril alignment or synthesis.

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Section: Taxol Generates Radial Swelling and Arrests Cell Division Bmentioning

confidence: 99%

Mutation or Drug-Dependent Microtubule Disruption Causes Radial Swelling without Altering Parallel Cellulose Microfibril Deposition in Arabidopsis Root Cells[W]

et al. 2003

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“…Tubulin has been exploited as a target for antineoplastics (8,25), herbicides (18), and antihelminthic (9,23), antifungal (14), and antiprotozoal (27,28,29) compounds. In addition, colchicine has been used for the treatment of gout in humans (2).…”

mentioning

confidence: 99%

Molecular Basis for Resistance of Acanthamoeba Tubulins to All Major Classes of Antitubulin Compounds

Henriquez

Ingram

Muench

et al. 2008

Antimicrob Agents Chemother

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“…Dinitroaniline herbicides (oryzalin, trifluralin), amiprophosmethyl (APM) and phenylcarbamates efficiently bind to plant tubulin and prevent microtubule polymerization. Plant tubulin has a high affinity to these herbicides, which, in turn, have no effect on animal tubulin; therefore these agents are broadly used in experimental studies of plant microtubule dynamic and function (Morejohn & Fosket, 1991).…”

Section: Resistance To Microtubule Depolymerizing Compoundsmentioning

confidence: 99%

Microtubules During the Cell Cycle of Higher Plant Cells

Smirnova¹

2012

Current Frontiers and Perspectives in Cell Biology

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The biochemistry of compounds with anti-microtubule activity in plant cells

Cited by 112 publications

References 119 publications

Mutation or Drug-Dependent Microtubule Disruption Causes Radial Swelling without Altering Parallel Cellulose Microfibril Deposition in Arabidopsis Root Cells[W]

Mutation or Drug-Dependent Microtubule Disruption Causes Radial Swelling without Altering Parallel Cellulose Microfibril Deposition in Arabidopsis Root Cells[W]

Molecular Basis for Resistance of Acanthamoeba Tubulins to All Major Classes of Antitubulin Compounds

Microtubules During the Cell Cycle of Higher Plant Cells

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