The biocompatibility of porous silicon in tissues of the eye

Low, Suet P.; Voelcker, Nicolas H.; Canham, Leigh; Williams, Keryn A.

doi:10.1016/j.biomaterials.2009.02.008

Cited by 292 publications

(243 citation statements)

References 33 publications

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“…2Ϫ4 While most of the research has been focused on microdevices for therapeutic use, 5 chemical and biological sensors, 6 and optoelectronics, 7 other applications have also emerged, such as intravenous 8 and ocular drug delivery. 9,10 Oral delivery still remains the route preferred by patients and thus dominates controlled release research. 11 Drug and peptide delivery by PSi particles has already been demonstrated and with promising results.…”

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confidence: 99%

Biocompatibility of Thermally Hydrocarbonized Porous Silicon Nanoparticles and their Biodistribution in Rats

et al. 2010

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Porous silicon (PSi) particles have been studied for the effects they elicit in Caco-2 and RAW 264.7 macrophage cells in terms of toxicity, oxidative stress, and inflammatory response. The most suitable particles were then functionalized with a novel 18 F label to assess their biodistribution after enteral and parenteral administration in a rat model. The results show that thermally hydrocarbonized porous silicon (THCPSi) nanoparticles did not induce any significant toxicity, oxidative stress, or inflammatory response in Caco-2 and RAW 264.7 macrophage cells. Fluorescently labeled nanoparticles were associated with the cells surface but were not extensively internalized. Biodistribution studies in rats using novel 18 F-labeled THCPSi nanoparticles demonstrated that the particles passed intact through the gastrointestinal tract after oral administration and were also not absorbed from a subcutaneous deposit. After intravenous administration, the particles were found mainly in the liver and spleen, indicating rapid removal from the circulation. Overall, these silicon-based nanosystems exhibit excellent in vivo stability, low cytotoxicity, and nonimmunogenic profiles, ideal for oral drug delivery purposes.

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confidence: 99%

Biocompatibility of Thermally Hydrocarbonized Porous Silicon Nanoparticles and their Biodistribution in Rats

et al. 2010

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“…Finally, recent reports have shown that the photonic properties of pSi allow self-reporting of drug loading and release [7,34]. An additional benefit associated with the use of pSi is that it can be processed into films supported on Si, free-standing membranes and micro-or nano-particles [32, [34][35][36][37][38].…”

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confidence: 99%

Controlled Drug Delivery From Composites of Nanostructured Porous Silicon and Poly( L -Lactide)

et al. 2012

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Aims: Porous silicon (pSi) and poly(L-lactide) (PLLA) both display good biocompatibility and tunable degradation behavior, suggesting that composites of both materials are suitable candidates as biomaterials for localized drug delivery into the human body. The combination of a pliable and soft polymeric material with a hard inorganic porous material of high drug loading capacity may engender improved control over degradation and drug release profiles and be beneficial for the preparation of advanced drug delivery devices and biodegradable implants or scaffolds. Materials & methods: In this work, three different pSi and PLLA composite formats were prepared. The first format involved grafting PLLA from pSi films via surface-initiated ring-opening polymerization (pSi–PLLA [grafted]). The second format involved spin coating a PLLA solution onto oxidized pSi films (pSi–PLLA [spin-coated]) and the third format consisted of a melt-cast PLLA monolith containing dispersed pSi microparticles (pSi–PLLA [monoliths]). The surface characterization of these composites was performed via infrared spectroscopy, scanning electron microscopy, atomic force microscopy and water contact angle measurements. The composite materials were loaded with a model cytotoxic drug, camptothecin (CPT). Drug release from the composites was monitored via fluorimetry and the release profiles of CPT showed distinct characteristics for each of the composites studied. Results: In some cases, controlled CPT release was observed for more than 5 days. The PLLA spin coat on pSi and the PLLA monolith containing pSi microparticles both released a CPT payload in accordance with the Higuchi and Ritger–Peppas release models. Composite materials were also brought into contact with human lens epithelial cells to determine the extent of cytotoxicity. Conclusion: We observed that all the CPT containing materials were highly efficient at releasing bioactive CPT, based on the cytotoxicity data. Original submitted 16 December 2010; Revised submitted 29 September 2011; Published online 6 March 2012

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“…The biocompatibility of both pSi and PCL have previously been demonstrated individually (Low et al, 2009;Ang et al, 2006) and together as a composite material (Kashanian et al, 2010) for use at the front of the eye. Different PCL composites have recently been tested as potential scaffolds for transplantation of retinal progenitor cell to the back of the eye (Baranov et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

“…Porous silicon (pSi) shows potential as a biocompatible scaffold for applications in orthopaedics (Li et al, 1998;Coffer et al, 2005;Whitehead et al, 2008;Anderson et al, 2010), oncology (Zhang et al, 2005;Mann et al, 2011;Park et al, 2011) and ophthalmology (Low et al, 2006;Cheng et al, 2008;Low et al, 2009;Kashanian et al, 2010). For use in ophthalmic implants designed to deliver drugs or cells to the eye, the advantages of pSi include its large surface area for drug-loading and cell attachment, and good ocular biocompatibility (Low et al, 2009;Kashanian et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

“…For use in ophthalmic implants designed to deliver drugs or cells to the eye, the advantages of pSi include its large surface area for drug-loading and cell attachment, and good ocular biocompatibility (Low et al, 2009;Kashanian et al, 2010). However, pSi is somewhat inflexible, is opaque, and shards of the membrane form of the material exhibit sharp edges.…”

Section: Introductionmentioning

confidence: 99%

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A novel pressed porous silicon-polycaprolactone composite as a dual-purpose implant for the delivery of cells and drugs to the eye

Irani

Tian

Wang

et al. 2015

Experimental Eye Research

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Abbreviations: BSS ophthalmic balanced salt solution; DMEM Dulbecco's Modified Eagle's Medium; EGF epidermal growth factor; FBS fetal bovine serum; FDA fluorescein diacetate; PBS phosphate buffered saline; PCL polycaprolactone; pSi nanostructured porous silicon; SEM scanning electron microscopy; TEM transmission electron microscopy. To investigate loading of large-molecule biologics, murine BALB/c 3T3 cells, responsive to epidermal growth factor, insulin and transferrin, were seeded on composite materials. The cells showed significantly more proliferation at 48 h when seeded on composites loaded with these biologics, than on unloaded composites. No cell proliferation was observed on PCL alone, indicating the biologics had loaded into the pSi microparticles. Drug release, measured by ELISA for insulin, indicated a burst followed by a slower, continuous release over six days. When implanted under the rat conjunctiva, the most promising composite material did not cause significant neovascularization but did elicit a macrophage and mild foreign body

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The biocompatibility of porous silicon in tissues of the eye

Cited by 292 publications

References 33 publications

Biocompatibility of Thermally Hydrocarbonized Porous Silicon Nanoparticles and their Biodistribution in Rats

Biocompatibility of Thermally Hydrocarbonized Porous Silicon Nanoparticles and their Biodistribution in Rats

Controlled Drug Delivery From Composites of Nanostructured Porous Silicon and Poly( L -Lactide)

A novel pressed porous silicon-polycaprolactone composite as a dual-purpose implant for the delivery of cells and drugs to the eye

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