The biodistribution and pharmacokinetic evaluation of choline-bound gold nanoparticles in a human prostate tumor xenograft model

Razzak, Rene; Zhou, Joe Q.; Yang, Xiaohong; Pervez, N.; Bédard, Éric; Moore, Ronald B.; Shaw, Andrew; Amanie, John; Roa, Wilson

doi:10.25011/cim.v36i3.19724

Cited by 8 publications

(8 citation statements)

References 38 publications

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“…Studies on AuNPs showed that these nanomaterials do not accumulate in the liver and do not elicit long-term hepatic dysfunction in animal models. 23,24 Data on the clearance of PEGylated gold nanomaterials also showed that once accumulated, gold nanocarriers were gradually cleared from the body. 24 In addition, as recently demonstrated by some of the authors of this study, 16 gold nanocarriers can be degraded within the cells.…”

Section: Introductionmentioning

confidence: 99%

Targeted polyethylene glycol gold nanoparticles for the treatment of pancreatic cancer: from synthesis to proof-of-concept in vitro studies

Spadavecchia¹,

Movia²,

Moore³

et al. 2016

IJN

167

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International audienceThe main objective of this study was to optimize and characterize a drug delivery carrier for doxorubicin, intended to be intravenously administered, capable of improving the therapeutic index of the chemotherapeutic agent itself, and aimed at the treatment of pancreatic cancer. In light of this goal, we report a robust one-step method for the synthesis of dicarboxylic acid-terminated polyethylene glycol (PEG)-gold nanoparticles (AuNPs) and doxorubicin-loaded PEG-AuNPs, and their further antibody targeting (anti-Kv11.1 polyclonal antibody [pAb]). In in vitro proof-of-concept studies, we evaluated the influence of the nanocarrier and of the active targeting functionality on the anti-tumor efficacy of doxorubicin, with respect to its half-maximal effective concentration (EC50) and drug-triggered changes in the cell cycle. Our results demonstrated that the therapeutic efficacy of doxorubicin was positively influenced not only by the active targeting exploited through anti-Kv11.1-pAb but also by the drug coupling with a nanometer-sized delivery system, which indeed resulted in a 30-fold decrease of doxorubicin EC50, cell cycle blockage, and drug localization in the cell nuclei. The cell internalization pathway was strongly influenced by the active targeting of the Kv11.1 subunit of the human Ether-à-go-go related gene 1 (hERG1) channel aberrantly expressed on the membrane of pancreatic cancer cells. Targeted PEG-AuNPs were translocated into the lysosomes and were associated to an increased lysosomal function in PANC-1 cells. Additionally, doxorubicin release into an aqueous environment was almost negligible after 7 days, suggesting that drug release from PEG-AuNPs was triggered by enzymatic activity. Although preliminary, data gathered from this study have considerable potential in the application of safe-by-design nano-enabled drug-delivery systems (ie, nanomedicines) for the treatment of pancreatic cancer, a disease with a poor prognosis and one of the main current burdens of today’s health care bill of industrialized countries

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Section: Introductionmentioning

confidence: 99%

Targeted polyethylene glycol gold nanoparticles for the treatment of pancreatic cancer: from synthesis to proof-of-concept in vitro studies

Spadavecchia¹,

Movia²,

Moore³

et al. 2016

IJN

167

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“…Choline is a ubiquitous molecule in all cells for which overactivity of processing enzymes (choline kinase) has been found in prostate tumors. One study reported development of polyethylene imine (PEI)- and choline-conjugated Au nanoparticles for the purpose of targeting prostate cancer for GNRT (Razzak et al, 2013 ) (Figure 1D ). While no radiation experiments were performed in this study, favorable pharmacokinetics were shown in mice.…”

Section: Gnrtmentioning

confidence: 99%

Gold nanoparticles and their alternatives for radiation therapy enhancement

2014

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Radiation therapy is one of the most commonly used treatments for cancer. The dose of delivered ionizing radiation can be amplified by the presence of high-Z materials via an enhancement of the photoelectric effect; the most widely studied material is gold (atomic number 79). However, a large amount is needed to obtain a significant dose enhancement, presenting a challenge for delivery. In order to make this technique of broader applicability, the gold must be targeted, or alternative formulations developed that do not rely solely on the photoelectric effect. One possible approach is to excite scintillating nanoparticles with ionizing radiation, and then exploit energy transfer between these particles and attached dyes in a manner analogous to photodynamic therapy (PDT). Doped rare-earth halides and semiconductor quantum dots have been investigated for this purpose. However, although the spectrum of emitted light after radiation excitation is usually similar to that seen with light excitation, the yield is not. Measurement of scintillation yields is challenging, and in many cases has been done only for bulk materials, with little understanding of how the principles translate to the nanoscale. Another alternative is to use local heating using gold or iron, followed by application of ionizing radiation. Hyperthermia pre-sensitizes the tumors, leading to an improved response. Another approach is to use chemotherapeutic drugs that can radiosensitize tumors. Drugs may be attached to high-Z nanoparticles or encapsulated. This article discusses each of these techniques, giving an overview of the current state of nanoparticle-assisted radiation therapy and future directions.

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“…As a support, AuNPs functionalized with thiocholine showed increased uptake in a human prostate tumor model and decreased intrahepatic accumulation compared with unmodified AuNPs. 41 Here, we report an unprecedented approach to prepare novel calixarene-coated gold nanoparticles (CholCalix-AuNPs) using a polycationic amphiphilic choline-calix [4]arene derivative (CholCalix) forming micelles and NADH, known to reduce the Au 3+ ion to AuNPs 42 (Scheme 1A). CholCalix-AuNPs were characterized for structure and optical properties using different techniques including UV−vis and Raman spectroscopies, dynamic light scattering (DLS), and atomic force microscopy (AFM).…”

Section: ■ Introductionmentioning

confidence: 99%

Near-Infrared-Responsive Choline-Calix[4]arene-Gold Nanostructures for Potential Photothermal Cancer Treatment

Consoli¹,

Forte

Maugeri

et al. 2022

ACS Appl. Nano Mater.

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The development of novel chemical approaches for the fabrication of gold nanostructures with localized surface plasmon resonance (LSPR) falling in the near-infrared (NIR) region is one challenging topic in nanomaterials science. Due to their optical and photothermal properties triggered by light excitation in the therapeutic window (λ max = 650−1300 nm), gold-based nanostructures are appealing candidates in anticancer nanomedicine. Here, we report a novel method to prepare waterdispersible gold nanostructures with NIR-LSPR (λ max = 600−1000 nm) properties. The gold nanostructures were achieved in a single step by an unconventional method using NADH as a reducing agent and an amphiphilic choline-calix[4]arene derivative (Chol-Calix) forming micelles as a template. The CholCalix-Au nanostructures were characterized by UV−visible spectrophotometry, Raman spectroscopy, and atomic force microscopy. Agglomeration of the nanostructures due to multiple crosslinking interactions was observed and supported by modeling simulation. Effective anticancer photothermal-induced effect of the CholCalix-AuNPs was demonstrated on human breast cancer cells irradiated with biofriendly light at 808 nm.

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The biodistribution and pharmacokinetic evaluation of choline-bound gold nanoparticles in a human prostate tumor xenograft model

Cited by 8 publications

References 38 publications

Targeted polyethylene glycol gold nanoparticles for the treatment of pancreatic cancer: from synthesis to proof-of-concept in vitro studies

Targeted polyethylene glycol gold nanoparticles for the treatment of pancreatic cancer: from synthesis to proof-of-concept in vitro studies

Gold nanoparticles and their alternatives for radiation therapy enhancement

Near-Infrared-Responsive Choline-Calix[4]arene-Gold Nanostructures for Potential Photothermal Cancer Treatment

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