The bioenergetics of COVID-19 immunopathology and the therapeutic potential of biophysical radiances

Surazakov, Arzhan; Klassen, A. C.; Гизингер, О. А.

doi:10.1016/j.jphotobiol.2020.112083

Cited by 7 publications

(4 citation statements)

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“…For every 1 °C increase in body temperature, a more than 10% increase is seen in metabolic rate. Then, the activation of adaptive immunity leads to rapid and extensive cell growth, and the proliferation of virus-specific T and B lymphocytes, which intensifies energy metabolism in the cells according to their sizes (19).…”

Section: Discussionmentioning

confidence: 99%

Measurement of the Body Physical Parameters by Bioelectrical Impedance Method in Individuals Survived after Covid-19

2023

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Objective: The coronavirus disease 2019 (Covid-19) has significantly affected human health around the world, causing many complications. However, it is not fully understood how the body compositions of individuals affected in the short or long term after disease. In this study, we aimed to show the effects of Covid-19 on body composition and phase angle values, using Bioelectrical Impedance Analayser. Methods: Subjects were selected from individuals in the 18-60 age group, who had survived COVID-19 disease. 33 individuals who had survived it 1-3 months ago, and 30 individuals who had survived it 3-6 months ago were included in the study. Results: Effects of COVID-19 on basal metabolism and body composition and the ratio of damaged cells in the body after the disease were determined. Basal metabolic rate, lean body mass, body cell mass, total body fluid, intracellular fluid, and phase angle values were found to be significantly changed in the 3-6 months range compared to that of 1-3 months. Conclusion: These results indicate that the basal metabolism and body composition parameters of the body become better, and the proportion of damaged cells decreases as time goes on after suffering COVID-19, reaching values close to normal in 1-3 months and quite better values in 3-6 months. It can be concluded that, although covid-19 influences body composition parameters and cell integrity in survivors of Covid 19 disease, these effects are limited to 3-6 months.

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Section: Discussionmentioning

confidence: 99%

Measurement of the Body Physical Parameters by Bioelectrical Impedance Method in Individuals Survived after Covid-19

2023

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“…During sepsis, iNOS is induced by various cell types, including immune cells, endothelial cells, as well as myocytes, in response to endogenously generated inflammatory mediators, such as cytokines, platelet products, superoxide anions, and NO itself [ 62 ]. NO generation from iNOS has been shown to suppress lymphocyte proliferation, and this might explain the exhaustion of lymphocytes in severe COVID-19 [ 63 , 64 ]. Ex vivo enhancement of septic patient’s platelet and endothelial cell eNOS activity reduces sepsis-related neutrophil–endothelial cell interactions and may play a role in maintaining microvascular patency during septic shock [ 65 ].…”

Section: About Nitric Oxidementioning

confidence: 99%

Nitric Oxide: The Missing Factor in COVID-19 Severity?

Nikolaidis

Kramer²,

Ostojić

2021

Medical Sciences

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Coronavirus disease 2019 (COVID-19) is a contagious respiratory and vascular disease that continues to spread among people around the world, mutating into new strains with increased transmission rates, such as the delta variant. The scientific community is struggling to discover the link between negative COVID-19 outcomes in patients with preexisting conditions, as well as identify the cause of the negative clinical patient outcomes (patients who need medical attention, including hospitalization) in what seems like a widespread range of COVID-19 symptoms that manifest atypically to any preexisting respiratory tract infectious diseases known so far. Having successfully developed a nutritional formulation intervention based on nitrate, a nitric oxide precursor, the authors hypothesis is that both the comorbidities associated with negative clinical patient outcomes and symptoms associated with COVID-19 sickness are linked to the depletion of a simple molecule: nitric oxide.

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“…Hence, progressive energy depletion leads to dysfunctional immune system and, ultimately, to cell death. Therefore, understanding the bioenergetics view of COVID-19 immunopathology, photomagnetic catalysis of ATP synthesis, regenerative photobiomodulation and the ultrasonic acceleration of cell restructuring has been proposed [219] , [220] . Furthermore, a coherent application of multiple biophysical radiances (coMra) in enhancing the energy-matter-information kinetics synergistically which may improve immune functions to accelerate recovery has also been proposed [220] .…”

Section: Potential Therapeutic Approachesmentioning

confidence: 99%