The Biogun: A novel way of eradicating methicillin-resistant Staphylococcus aureus colonization in diabetic foot ulcers

Dang, C. N.

doi:10.2337/diacare.2951176

Cited by 3 publications

(5 citation statements)

References 2 publications

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“…the use of maggots to cleanse wounds and promote healing) has been used to eradicate MRSA infections in patients with chronic diabetic foot ulcers. [19,20] Prevention is important to avoid spread [18] A nonblind pilot study found that the Dentron Biogun, which ionizes molecular oxygen and generates superoxide radical anions with antibactericidal effects, eradicated MRSA colonization in 60% of diabetic foot ulcers.…”

Section: Diabetic Foot Ulcers Are Challengingmentioning

confidence: 99%

Choose antibacterial carefully when treating methicillin-resistant Staphylococcus aureus diabetic foot infections

&NA;

2011

Drugs & Therapy Perspectives

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The proper use of antibacterials is essential to successfully treat methicillin-resistant Staphylococcus aureus (MRSA) in diabetic foot infections. Mild to moderate MRSA infections may be treated with cotrimoxazole (trimethoprim/ sulfamethoxazole), doxycycline or clindamycin in the outpatient setting. However, severe MRSA infections require inpatient treatment with a regimen that includes daptomycin, a glycopeptide or linezolid.

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Section: Diabetic Foot Ulcers Are Challengingmentioning

confidence: 99%

Choose antibacterial carefully when treating methicillin-resistant Staphylococcus aureus diabetic foot infections

&NA;

2011

Drugs & Therapy Perspectives

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“…Another novel method of treating infected foot ulcers is the so-called 'Biogun.' [51,52] This device ionizes molecular oxygen and generates superoxide radical anions (O 2 − ) that have a bactericidal effect against micro-organisms. In a pilot study of 15 patients with MRSA colonization of diabetic foot ulcer, this device eradicated the organism from 60%.…”

Section: Topical and Local Anti-microbialsmentioning

confidence: 99%

New developments in diagnosing and treating diabetic foot infections

Lipsky

2008

Diabetes Metab. Res. Rev.

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Foot infections are common in persons with diabetes and are often the proximate cause of lower extremity amputation. There have been many publications in the past few years dealing with the appropriate ways to diagnose and treat diabetic foot infections. This review presents information gathered from a comprehensive, ongoing surveillance of the literature (published and abstracts) over the past 4 years. Prospective studies have now defined the epidemiology of diabetic foot infections, as well as methods to score and classify the wounds. Several recently published guidelines can assist clinicians in managing these infections. The etiologic agents of infection have been well-defined, and the prevalence of multi-drug-resistance pathogens is growing. Molecular methods offer great promise for quicker and more sensitive diagnosis of infection. New antimicrobial agents, both systemic and topical, as well as novel local treatments, have been shown to be effective in various studies. Improved methods of deploying older agents have added to the variety of treatment approaches now available. Several adjunctive treatments may benefit some patients but their role is as yet unclear. While there is much yet to learn about the most cost-effective ways to diagnose and treat diabetic foot infections the main effort is now to disseminate the available information and facilitate employing the evidence-based guideline recommendations.

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“…The Biogun probe was placed 2-10 mm above the ulcer surface and was moved across the ulcer surface at a speed of not Ͻ60 s/cm 2 . During treatment, the Biogun probe did not come into contact with the ulcer surface (2).…”

mentioning

confidence: 99%

“…These Manchester Royal Infirmary clinicians have been leaders in documenting the problem of MRSA in diabetic foot lesions. As the incidence of colonization and subsequent infection with this virulent pathogen is rising in both the hospital and community, we need approaches to eradication that will not further drive antibiotic resistance (2).…”

mentioning

confidence: 99%

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