The biologic effects of implant materials

Galante, Jorge O.; Lemons, Jack E.; Spector, Myron; Wilson, Philip D.; Wright, Timothy M.

doi:10.1002/jor.1100090516

Cited by 196 publications

(89 citation statements)

References 61 publications

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“…Como o plasma permeia toda a câmara, os íons de nitrogênio ao atingir as paredes da câmara, podem causar a ejeção (sputtering) destes elementos. Estudos prévios comprovam que o cromo é citotóxico a diversos tipos de célula, em especial osteoblastos, cuja viabilidade e proliferação são afetadas e, consequentemente, a osseointegração torna-se um problema [34][35][36]. Íons de ferro também mostram toxicidade, quando em forma de detritos em implantes ósseos [37].…”

Section: Materiais E Métodosunclassified

Implantação de Íons de Nitrogênio em PMMA Através de uma Fonte Kaufman

Fontoura¹,

Wanke²,

Aguzzoli³

2017

Sci. cum Ind.

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ResumoA modificação de superfícies é uma técnica que a engenharia tem feito uso há muito tempo, para melhoria de propriedades em materiais. O poli metil-metacrilato (PMMA), por ser um material de constante uso em aplicações biomédicas, exige que sua superfície apresente características favoráveis à adesão celular e compatibilidade com tecidos. Os polímeros, de uma maneira geral, quando submetidos a tratamentos em plasma, tendem a formar grupos funcionais que alteram propriedades ópticas, químicas, físicas e de biocompatibilidade. Em função disso, este trabalho propôs realizar a funcionalização de substratos de PMMA através da fonte de íons Kaufman. Amostras de PMMA foram submetidas ao feixe de íons de nitrogênio gerado pela fonte Kaufman, em diversas condições. A caracterização foi feita pelas técnicas de GD-OES, FTIR e EDS. Ficou comprovado, através do perfil de concentração de nitrogênio obtido por GD-OES, que a quantidade de nitrogênio na superfície aumenta gradativamente com o tempo de implantação e a potência. Outro indício foi a análise em FTIR, que mostrou presença de aminas nas faixas entre 1654-655 cm -1 e 3300-3700 cm -1 . A análise em EDS, porém, comprovou também a presença de ferro e cromo, agentes citotóxicos, que precisam ser eliminados para a continuidade dos trabalhos. Palavras-chaveImplantação de íons de nitrogênio, fonte de íons Kaufman, modificação superficial de PMMA Implantation of Nitrogen Ions through a Kaufman Ion Source AbstractSurface modification is a technique that engineering has been using for a long time, in order to improve the properties of materials. Poly (methyl methacrylate) (PMMA), for being a material of constant use in biomedical applications, demands that its surface offers favorable characteristics in cell adhesion and tissue compatibility. Polymers, generally speaking, when submitted to plasma treatments, tend to form functional groups that alter optical, chemical, physical and biocompatibility properties. Taking all of this into consideration, this work proposed to functionalize PMMA substrates through a Kaufman ion source. PMMA samples were submitted to a nitrogen ion beam generated through the Kaufman source, in different conditions. Characterization was carried out by the techniques of GD-OES, FTIR and EDS. It was proved, through nitrogen concentration profile obtained by GD-OES, that the amount of nitrogen in the surface increased gradually with implantation time and supplied power. The FTIR analysis was another evidence of nitrogen presence, as amines were detected in the bands between 1654-655 cm -1 and 3300-3700 cm -1 . The EDS analysis, though, proved that iron and chromium, cytotoxic agents, are also present and therefore, they must be eliminated from the process, so that future studies can be carried out.

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Section: Materiais E Métodosunclassified

Implantação de Íons de Nitrogênio em PMMA Através de uma Fonte Kaufman

Fontoura¹,

Wanke²,

Aguzzoli³

2017

Sci. cum Ind.

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“…The information for inert metal toxicity in humans arises from foreign-body carcinogenesis data related to metals used for implants, stainless steel, shrapnel, etc. (Brand and Brand, 1980;Brand, 1994;Galante et al, 1991). Ta metal is physiologically inert and has been used in metal implants in animals and humans for many years (Beliles et al, 1994) without observed biologic effects.…”

Section: -Signature Datementioning

confidence: 99%

Carcinogenesis of Depleted Uranium

Hahn¹

2006

Depleted Uranium

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“…In an effort to continuously improve prosthetic materials, cementless joint replacements have been tried. However, lytic reactions have occurred, suggesting that similar tissue reactions may occur in a variety of fragmented materials, including metals (7).…”

Section: Tb and Foreign-body Reactions In A Knee Prosthesismentioning

confidence: 99%

Tuberculous and foreign‐body granulomatous reactions involving a total knee prosthesis

Lusk

Wienke

Milligan³

et al. 1995

Arthritis & Rheumatism

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This case report describes loosening of a right knee prosthesis and represents the first report of the simultaneous occurrence of 2 granulomatous processes involving a prosthetic joint. Microscopic examination of the tissue revealed areas of foreign-body granulomas and areas of necrotizing granulomas and caseation. Acid-fast bacilli cultures were positive for Mycobucterium tuberculosis. The pathophysiology of implant 100s-ening following an inflammatory reaction to components of prosthetic materials is discussed. Also discussed is the occurrence of infectious complications and rarity of tuberculous infections associated with prosthetic irnplants.

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The biologic effects of implant materials

Cited by 196 publications

References 61 publications

Implantação de Íons de Nitrogênio em PMMA Através de uma Fonte Kaufman

Implantação de Íons de Nitrogênio em PMMA Através de uma Fonte Kaufman

Carcinogenesis of Depleted Uranium

Tuberculous and foreign‐body granulomatous reactions involving a total knee prosthesis

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