The Biological Effect of Small Extracellular Vesicles on Colorectal Cancer Metastasis

Wang, Xiaoxing; Huang, Defa; Wu, Jiyang; Li, Zhengzhe; Yi, Xiaomei; Zhong, Tianyu

doi:10.3390/cells11244071

Cited by 5 publications

(3 citation statements)

References 90 publications

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“…A thorough search yielded 846 articles initially. After a comprehensive screening process, which involved eliminating duplicates, assessing full-text availability and evaluating compliance with our inclusion criteria, a total of seven studies [10][11][12][13][14][15][16] were selected for inclusion in our meta-analysis. These trials encompassed 1256 patients undergoing colorectal surgery, with subsets receiving TCM treatment or serving as control groups.…”

Section: Identification and Selection Of Studiesmentioning

confidence: 99%

Evaluating traditional Chinese medicine (TCM) Jie Geng and Huang Qi combination on reducing surgical site infections in colorectal cancer surgeries: A systematic review and meta‐analysis

Chen,

Tian,

et al. 2024

International Wound Journal

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Postoperative wound infections (PWIs) pose a significant challenge in colorectal cancer surgeries, leading to prolonged hospital stays and increased morbidity. This systematic review and meta‐analysis evaluated the efficacy of the traditional Chinese medicine (TCM) combination of Jie Geng and Huang Qi in reducing PWIs following colorectal cancer surgeries. Adhering to PRISMA guidelines, we focused on seven randomized controlled trials (RCTs) involving 1256 patients, examining the incidence of PWIs within 30 days post‐surgery, alongside secondary outcomes such as length of hospital stay and antibiotic use. The analysis revealed a significant reduction in PWI incidence in the TCM‐treated group compared to controls, with a Risk Ratio of 0.21 (95% CI: 0.14 to 0.30, p < 0.01), a notable decrease in hospital stay (Mean Difference: 1.2 days, 95% CI: 0.15 to 1.28 days, p < 0.01) and a significant reduction in antibiotic use (Risk Ratio: 0.24, 95% CI: 0.16 to 0.36, p < 0.01). These findings suggest that Jie Geng and Huang Qi in TCM could be an effective adjunct in postoperative care for colorectal cancer surgeries, underscoring the need for further high‐quality RCTs to substantiate these results and explore the underlying mechanisms.

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Section: Identification and Selection Of Studiesmentioning

confidence: 99%

Evaluating traditional Chinese medicine (TCM) Jie Geng and Huang Qi combination on reducing surgical site infections in colorectal cancer surgeries: A systematic review and meta‐analysis

Chen,

Tian,

et al. 2024

International Wound Journal

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“…Tumor-associated macrophage (TAM) are macrophages that infiltrate tumor tissues and are derived from circulating peripheral blood mononuclear cells ( 14 ). Tumor cells secrete a plethora of chemokines, including colony-stimulating factor-1 and interleukins, to attract monocytes from the peripheral blood circulation into the tumor microenvironment (TME), ultimately inducing monocytes to differentiate into macrophages ( 15 ).…”

Section: Evs In Rcc Deteriorationmentioning

confidence: 99%

Extracellular vesicles in renal cell carcinoma: challenges and opportunities coexist

Zhang

Zhou

et al. 2023

Front. Immunol.

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Renal cell carcinoma (RCC) represents an extremely challenging disease in terms of both diagnosis and treatment. It poses a significant threat to human health, with incidence rates increasing at a yearly rate of roughly 2%. Extracellular vesicles (EVs) are lipid-based bilayer structures of membranes that are essential for intercellular interaction and have been linked to the advancement of RCC. This review provides an overview of recent studies on the role of EVs in RCC progression, including involvement in the interaction of tumor cells with M2 macrophages, mediating the generation of immune tolerance, and assuming the role of communication messengers in the tumor microenvironment leading to disease progression. Finally, the “ troika “ of EVs in RCC therapy is presented, including engineered sEVs’ or EVs tumor vaccines, mesenchymal stem cell EVs therapy, and reduction of tumor-derived EVs secretion. In this context, we highlight the limitations and challenges of EV-based research and the prospects for future developments in this field. Overall, this review provides a comprehensive summary of the role of EVs in RCC and their potential as a viable pathway for the future treatment of this complex disease.

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“…Additionally, adequate nutrient supply is essential for tumor growth and metastasis. Neoangiogenesis provides a foundation for tumor growth and metastasis, while vascular leakage provides more pathways for tumor cell dissemination ( Wang et al, 2022a ). These factors interact with each other, ultimately promoting GC metastasis.…”

Section: Introductionmentioning

confidence: 99%

The biological role of extracellular vesicles in gastric cancer metastasis

Lei,

Cai,

Zhang

et al. 2024

Front. Cell Dev. Biol.

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Gastric cancer (GC) is a tumor characterized by high incidence and mortality, with metastasis being the primary cause of poor prognosis. Extracellular vesicles (EVs) are an important intercellular communication medium. They contain bioactive substances such as proteins, nucleic acids, and lipids. EVs play a crucial biological role in the process of GC metastasis. Through mechanisms such as remodeling the tumor microenvironment (TME), immune suppression, promoting angiogenesis, and facilitating epithelial–mesenchymal transition (EMT) and mesothelial–mesenchymal transition (MMT), EVs promote invasion and metastasis in GC. Further exploration of the biological roles of EVs will contribute to our understanding of the mechanisms underlying GC metastasis and may provide novel targets and strategies for the diagnosis and treatment of GC. In this review, we summarize the mechanisms by which EVs influence GC metastasis from four aspects: remodeling the TME, modulating the immune system, influencing angiogenesis, and modulating the processes of EMT and MMT. Finally, we briefly summarized the organotropism of GC metastasis as well as the potential and limitations of EVs in GC.

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The Biological Effect of Small Extracellular Vesicles on Colorectal Cancer Metastasis

Cited by 5 publications

References 90 publications

Evaluating traditional Chinese medicine (TCM) Jie Geng and Huang Qi combination on reducing surgical site infections in colorectal cancer surgeries: A systematic review and meta‐analysis

Evaluating traditional Chinese medicine (TCM) Jie Geng and Huang Qi combination on reducing surgical site infections in colorectal cancer surgeries: A systematic review and meta‐analysis

Extracellular vesicles in renal cell carcinoma: challenges and opportunities coexist

The biological role of extracellular vesicles in gastric cancer metastasis

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