The Biological Implications of the Abnormal Expression of Histocompatibility Antigens on Murine and Human Tumors

Garrido, Federico

doi:10.1007/978-1-4757-0764-9_60

Cited by 7 publications

(5 citation statements)

References 24 publications

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“…Alterations in the expression of histocompatibility antigens are among the molecular events that appear to be associated with oncogenesis [18,19]. Changes may consist of the de novo appearance, reduction, or total loss of these antigens [38].…”

Section: Introductionmentioning

confidence: 99%

HLA-DR expression is associated with excellent prognosis in squamous cell carcinoma of the larynx

et al. 1990

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We studied class II antigen expression and tumor-infiltrating leukocytes (TIL) in tissue sections of 69 squamous cell carcinomas of the larynx and 24 lymph node metastases in the neck. HLA-DR expression was found only in eight well-differentiated, highly keratinizing squamous cell carcinomas comprising seven of the verrucous variety and one ventriculosaccular tumor. None of the metastases was positive for DR antigen. Neither primary tumors nor autologous metastases stained for DP or DQ antigens. DR-positive tumors shared a peculiar pattern of TIL composed mainly of T cells, most of which belonged to the cytotoxic/suppressor subset, and B cells. These neoplasms had in common a slow rate of growth, and are considered low-grade carcinomas in the literature. We conclude from our study that HLA-DR expression seems to characterize tumors with a prominent infiltrate and an excellent prognosis.

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Section: Introductionmentioning

confidence: 99%

HLA-DR expression is associated with excellent prognosis in squamous cell carcinoma of the larynx

et al. 1990

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“…Alterations in HLA-ABC expression may be one method used by cancer cells to avoid immune destruction (Garrido, 1987). Decreased HLA expression has been discovered in several human tumours, including breast, lung, skin, colorectal, gastric and laryngeal carcinomas (L6pez-Nevot et al, 1986(L6pez-Nevot et al, , 1989Redondo et al, 1991;.…”

mentioning

confidence: 99%

MHC class I antigens and tumour-infiltrating leucocytes in laryngeal cancer: long-term follow-up

Esteban

Redondo²,

Delgado³

et al. 1996

Br J Cancer

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Summary Alteration in MHC class I expression may be used by cancer cells to avoid immune destruction. Much experimental evidence supports this idea, although survival studies are very scarce. To investigate whether the presence or absence of HLA-A, -B and -C antigens in laryngeal carcinoma influences survival, a series of 60 primary laryngeal tumours treated surgically and normal tissues were evaluated in frozen sections for the expression of MHC class I antigens and tumour-infiltrating leucocytes (CD3, CD4, CD8, CD1Ib, CD1, CD20 and CDI6), using monoclonal antibodies and the APAAP technique. Long-term follow-up from the patients is available, ranging from 6 to 10 years. Thirteen tumours presented total HLA-ABC loss, five selective losses of HLA-A antigens and one absence of HLA-B antigens. Total losses were statistically associated with several clinical and pathological parameters, but there were no differences regarding tumour-infiltrating leucocytes. After conducting a prospective study, only T and N staging and scoring according to Glanz's malignancy classification were found to be independently related to patients' outcome. From our data, we conclude that neither complete loss of HLA class I antigens nor tumour-infiltrating leucocytes appear to influence survival in squamous cell carcinoma of the larynx.

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“…MHC class I and II antigens are required for peptide presentation to the immune system, including peptides acting as tumour antigens (Townsend et al, 1985). Alterations in HLA-ABC expression may be one way used by cancer cells to avoid immune destruction (Garrido, 1987). Decreased HLA expression has been discovered in several human tumours, including breast, skin, colorectal, gastric and laryngeal carcinomas (L6pez- Nevot et al, 1986Ruiz-Cabello et al, 1989).…”

mentioning

confidence: 99%

Lack of MHC class I antigens and tumour aggressiveness of the squamous cell carcinoma of the larynx

Esteban

Concha²,

Delgado³

et al. 1990

Br J Cancer

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Summary A series of 60 primary laryngeal and hypopharyngeal tumours, 24 lymph node metastases and normal tissue were evaluated in frozen sections for the expression of MHC class I antigens, using monoclonal antibodies and the APAAP technique. We found 13 tumours presenting total HLA-ABC loss, five with selective loss of HLA-A antigens and one with absence of HLA-B antigens. These losses were statistically associated with clinical and pathological parameters, such as T stage, degree of differentiation, scores according to the Jakobsson and Glanz grading systems and degree of leukocytic infiltration. Our results lead us to the following conclusions: (a) HLA class I losses were found in a group of tumours showing greater aggressiveness and worse prognosis; (b) these alterations in expression were not associated with an increased metastatic potential. Thus, the absence of HLA molecules in laryngeal tumours is related to greater local aggressiveness, and the loss of class I antigens seems to constitute an adaptive tumour mechanism to avoid the different anatomical and immunological barriers within the larynx.

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The Biological Implications of the Abnormal Expression of Histocompatibility Antigens on Murine and Human Tumors

Cited by 7 publications

References 24 publications

HLA-DR expression is associated with excellent prognosis in squamous cell carcinoma of the larynx

HLA-DR expression is associated with excellent prognosis in squamous cell carcinoma of the larynx

MHC class I antigens and tumour-infiltrating leucocytes in laryngeal cancer: long-term follow-up

Lack of MHC class I antigens and tumour aggressiveness of the squamous cell carcinoma of the larynx

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