The biological role of strontium

Nielsen, S. Pors

doi:10.1016/j.bone.2004.04.026

Cited by 609 publications

(326 citation statements)

References 37 publications

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“…Strontium is of profound importance in biomedical science [1], particularly because of its effect on bone growth. Strontium is naturally occurring in the human body, although at very low quantities, where it acts as a ''bone seeker'' like calcium, to the point that *99% of the body's strontium is found in bone.…”

Section: Introductionmentioning

confidence: 99%

“…As a result, strontium ranelate is an approved treatment for osteoporosis in postmenopausal women [3][4][5][6], who have an increased prevalence of the disease, whereas strontium malonate is currently undergoing clinical trials. Strontium intake also leads to greater deposition of calcium in bone [1]. Other medical uses of strontium include exploiting its bactericidal nature for injectable bone cement [7] and as an adjunct to radiotherapy [8].…”

Section: Introductionmentioning

confidence: 99%

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Effect of strontium inclusion on the bioactivity of phosphate-based glasses

Christie

Leeuw

2017

J Mater Sci

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We have conducted first-principles and classical molecular dynamics simulations of various compositions of strontium-containing phosphate glasses, to understand how strontium incorporation will change the glasses' activity when implanted into the body (bioactivity). To perform the classical simulations, we have developed a new interatomic potential, which takes account of the polarizability of the oxygen ions. The Sr-O bond length is *2.44-2.49 Å , and the coordination number is 7.5-7.8. The Q n distribution and network connectivity were roughly constant for these compositions. Sr bonds to a similar number of phosphate chains as Ca does; based on our previous work (Christie et al. in J Phys Chem B 117:10652, 2013), this implies that SrO $ CaO substitution will barely change the dissolution rate of these glasses and that the bioactivity will remain essentially constant. Strontium could therefore be incorporated into phosphate glass for biomedical applications.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of strontium inclusion on the bioactivity of phosphate-based glasses

Christie

Leeuw

2017

J Mater Sci

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“…However, its stable isotopes are not considered as a toxic. Its biological role focused scientific interests especially in bones (Nielsen 2004;Dahl et al 2001). The adsorption of strontium ions on the hydroxyapatite surface and hydroxyapatite or/and substitution of strontium ions hydroxyapatite crystal structure changing the hydroxyapatite properties such as solubility and bone mineral density (Christoffersen et al 1997).…”

Section: Introductionmentioning

confidence: 99%

Study of sorption processes of strontium on the synthetic hydroxyapatite

Janusz

Skwarek

2016

Adsorption

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Adsorption of 90 Sr on hydroxyapatite is important in many fields of life. The aim of the paper was to discuss the changes in the double electrical layer at the hydroxyapatite/electrolyte solution interface during Sr ions adsorption and to establish the relations between time and adsorption on this material. Hydroxyapatite was prepared by the wet method, characterized by the X-ray diffraction and accelerated surface area and porosimetry methods. Studies of adsorption were carried out using 90 Sr isotopes and ionic solutions containing this ion depending on concentration and pH of the solution. Sr adsorption isotherms on hydroxyapatite were determined and the effect of strontium ions presence on the surface charge density and zeta potential was discussed.

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“…If radioisotope 90 Sr enters bone, it irradiates localized tissues, leading to leukemia, bone sarcoma, and other chronic problems [6,7]. Therefore, Sr is considered one of the most dangerous radionuclides to human health due to its The low-cost, composite magnetic nanoparticles of CuFe 2 O 4 were manufactured after the ferrite process.…”

Section: Introductionmentioning

confidence: 99%

Strontium Removal in Seawater by Means of Composite Magnetic Nanoparticles Derived from Industrial Sludge

You

Zhang

et al. 2016

Water

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Novel composite magnetic nanoparticles (CuFe 2 O 4 ) were synthesized from industrial sludge by acid leaching, chemical exchange, and ferrite processes in the laboratory. For the first time, these products were applied to investigate the Sr adsorption kinetics and the related thermodynamics in seawater. Rapidly enhanced Sr adsorption was observed when the solution pH changed from 2.61 to 10.25. The maximum adsorption capacity was 23.04 mg·g −1 at 318 K (pH 10.25). Sr adsorption decreased with the increase of the ionic strength from 0.01 to 0.5 mol·L −1 at pH 2.61-pH 10.25, indicating that the outer-sphere mechanism was involved in the Sr adsorption at the pH interval. This reaction is spontaneous and endothermic, as indicated by the negative change in the standard free energy (∆G • = −5.68, −6.45, and −7.23 kJ·mol −1 at 298, 308, and 318 K, respectively) and positive ∆H • value (2.11 kJ·mol −1 ). The positive ∆S • (9.38 mol −1 ·K −1 ) further confirms that the randomness increased at the solid-solution interface during adsorption. These new results indicate that the composite magnetic nanoparticles can be used for the removal of radiogenic 90 Sr nuclide in seawater that was released after the 3/11 earthquake offshore of Japan.

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The biological role of strontium

Cited by 609 publications

References 37 publications

Effect of strontium inclusion on the bioactivity of phosphate-based glasses

Effect of strontium inclusion on the bioactivity of phosphate-based glasses

Study of sorption processes of strontium on the synthetic hydroxyapatite

Strontium Removal in Seawater by Means of Composite Magnetic Nanoparticles Derived from Industrial Sludge

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