The Biological Roles of Steroid Sulfonation

Dawson, Paul A.

doi:10.5772/52714

Steroids - From Physiology to Clinical Medicine 2012

DOI: 10.5772/52714

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The Biological Roles of Steroid Sulfonation

Paul A. Dawson¹

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Cited by 4 publications

References 102 publications

(137 reference statements)

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Current insights into the sulfatase pathway in human testis and cultured Sertoli cells

Hartmann

Bennien

Wapelhorst

et al. 2016

Histochem Cell Biol

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Within the human testis, large amounts of sulfated steroid hormones are produced. As shown in breast tissue and placenta, these might not only be excretion intermediates, but re-activated in target cells by steroid sulfatase (STS). This process is called sulfatase pathway and may play a pivotal role in para- and/or intracrine regulation by creating a local supply for steroid hormones. This requires a facilitated transport via uptake carriers and efflux transporters as these hydrophilic molecules cannot pass the cell membrane. Moreover, blood-testis barrier formation in the testis requires a transport through Sertoli cells (SCs) to reach germ cells (GCs). Sertoli cells are therefore expected to play a key role as gate-keepers for sulfatase pathway in human seminiferous epithelium. We analyzed the mRNA and protein expression of uptake carriers and efflux transporters like organic anion-transporting polypeptides (OATP2B1, OATP3A1) and multidrug resistance-related proteins (MRP1, MRP4) in testicular tissue and cultured Sertoli cells (FS1, HSEC). Additionally, expression pattern of STS as well as sulfonating enzymes (SULTs) were assessed. OATP2B1, OATP3A1 and STS were detected in SCs as well as GCs, whereas MRP1 is only expressed in SCs, and SULT1E1 only in Leydig cells, respectively. By transcellular transport of [H]DHEAS in HSEC, we showed a functional transport of sulfated steroids in vitro. Our data indicate that steroid synthesis via sulfatase pathway in Sertoli cells in vivo and in vitro is possible and may contribute to paracrine and intracrine regulation employing the local supply of sulfated and free steroid hormones inside seminiferous tubules.

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Current insights into the sulfatase pathway in human testis and cultured Sertoli cells

Hartmann

Bennien

Wapelhorst

et al. 2016

Histochem Cell Biol

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Synthesis of sulfated brassinosteroids

et al. 2017

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The effect of epibrassinolide and its sulfuric acid esters on the morphometric parameters of sunflower <i>Helianthus annuus</i> L. (cv. Helios)

Khamiuk

Litvinovskaya

Kolbas

2022

Vescì Akademìì navuk Belarusì. Seryâ biâlagičnyh navuk

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A step-by-step study of the biological activity of 24-epibrassinolide (EB) and its sodium salts of esters with sulfuric acid (sodium 2-, 3-, 22and 23-monosulfates and disodium 2.3-disulfate EB) was carried out in experiments on the effect on the growth parameters and crop yield of annual sunflower Helianthus annuus L. (Helios variety) depending on growing conditions. In experiments on a groundless medium, the effect of epibrassinolide sulfuric acid esters on primary plant growth at concentrations of 10–11–10–9 М turned out to be insignificant (with the exception of disodium 2.3–disulfate EB), to a greater extent the activity of the studied compounds was marked in laboratory experiment in soil culture. The greatest effect on growth and development plant was noted in field experiments. It is shown that the most effective and universal compound according to the studied parameters for two types of treatment (soaking seeds and spraying plants) is disodium 2.3-disulfate EB.

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The Biological Roles of Steroid Sulfonation

Cited by 4 publications

References 102 publications

Current insights into the sulfatase pathway in human testis and cultured Sertoli cells

Current insights into the sulfatase pathway in human testis and cultured Sertoli cells

Synthesis of sulfated brassinosteroids

The effect of epibrassinolide and its sulfuric acid esters on the morphometric parameters of sunflower <i>Helianthus annuus</i> L. (cv. Helios)

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