The biological significance of plasmalogens in defense against oxidative damage

Brosche, Thorolf; Platt, D.

doi:10.1016/s0531-5565(98)00014-x

Cited by 106 publications

(79 citation statements)

References 37 publications

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“…In a large population study, circulating plasmalogen levels were observed to decrease prior to the development of AD symptoms ( 33 ). Plasmalogens as a class are enriched in AA chains ( 38 ), and many investigators have suggested that plasmalogens have a protective role against oxidative damage (44)(45)(46)(47)(48)(49)(50) by virtue of their own particular susceptibility to oxidation ( 51 ). A vinyl ether group in the sn1 position of a phospholipid increases the oxidative susceptibility of polyunsaturated AA chains at the sn2 position (52)(53)(54)(55).…”

Section: Discussionmentioning

confidence: 99%

Quantitative analysis of phospholipids containing arachidonate and docosahexaenoate chains in microdissected regions of mouse brain

Axelsen

Murphy

2010

Journal of Lipid Research

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Section: Discussionmentioning

confidence: 99%

Quantitative analysis of phospholipids containing arachidonate and docosahexaenoate chains in microdissected regions of mouse brain

Axelsen

Murphy

2010

Journal of Lipid Research

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“…This could help minimise proton leak across mitochondrial membranes at elevated temperature. In vitro, the higher susceptibility of the vinyl-ether bond to oxidative attack led to the hypothesis that plasmalogens may act as anti-oxidants, protecting cells from oxidative stress (Brosche and Platt, 1998;Maeba and Ueta, 2003;Brites et al, 2004). Generation of free radical species of oxygen during mitochondrial electron transport chain can damage mitochondrial membranes and hinder function by generating lipid peroxides from unsaturated FA (Chang and Roots, 1985;Genova et al, 2004).…”

Section: Phospholipid Classes and Subclasses Restructuringmentioning

confidence: 99%

Changes in mitochondrial oxidative capacities during thermal acclimation of rainbow trout Oncorhynchus mykiss: roles of membrane proteins,phospholipids and their fatty acid compositions

Kraffe

Marty

Guderley

2007

Journal of Experimental Biology

133

116

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International audienceChanges in the properties of mitochondria from oxidative muscle of rainbow trout Oncorhynchus mykiss were examined during warm (5 degrees C to 15 degrees C) acclimation. Trout were studied shortly after the initial thermal change and after 8 weeks acclimation to 15 degrees C. To identify potential mechanisms by which oxidative capacities change, the modifications of phospholipid composition, membrane proteins and functional capacities of red muscle mitochondria were examined. Marked functional changes of isolated muscle mitochondria during warm acclimation of rainbow trout were reflected by a host of modifications in phospholipid composition, but by few shifts in protein components. Shortly after transfer of trout from 5 degrees C to 15 degrees C, the maximal oxidative capacity of mitochondria measured at 15 degrees C increased slightly, but rates at both assay temperatures (5 degrees C and 15 degrees C) decreased markedly after warm acclimation. The increase in capacity in short-term warm exposed trout was most pronounced when rates at 15 degrees C were expressed relative to cytochrome a and c(1) levels. Non-phosphorylating (State 4) rates of oxygen uptake increased with short-term warm exposure before returning to initial levels after warm acclimation. Cytochrome c oxidase (CCO) activity in the mitochondrial preparations decreased with warm acclimation. The thermal sensitivity of the ADP affinity was markedly modified during short-term warm exposure, when the ADP/O ratio increased, but warm acclimation returned these values to those observed initially. ADP affinity increased after warm acclimation. Changes in the mitochondrial content of cytochromes and adenine nucleotide translocase (ANT) could not explain these patterns. On the other hand, changes in the proportions of the lipid classes and in the acyl chain composition of certain phospholipid classes mirror the modifications in functional properties. Short-term exposure to 15 degrees C decreased the ratio of diacylphosphatidylethanolamine/diacylphosphatidylcholine (diacylPE/diacylPC), whereas warm acclimation led to restructuring of fatty acids (FA) and to increases of plasmalogen forms of PE and PC. Modification of overall membrane unsaturation did not appear to be the primary aim of restructuring membrane FA during warm acclimation, as total mitochondrial phospholipids and the major phospholipid classes only showed slight shifts of their acyl composition with warm acclimation. On the other hand, natural lysophosphatidylcholine (LysoPC) showed dramatic changes in FA content, as 16:0 and 18:1n-9 doubled whereas 22:6n-3 decreased from around 50% to 32% in warm acclimated trout. Similarly, in cardiolipin (CL), the levels of 16:0 and 18:1n-7 halved while 18:2n-6 increased to over 20% of the FA with warm acclimation. Given the central role of CL in modulating the activity of CCO, F(0)F(1)-ATPase and ANT, these changes suggest that specific compositional changes in CL are important modulators of mitochondrial capacities. The many structural ...

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“…Plasmalogens are very high in both central nervous system and the heart but their precise role is not clear. They have been implicated in age-related degenerative diseases and have been proposed to be important membrane antioxidants (Zoeller et al 1988;Brosche and Platt 1998). The relative abundance of plasmalogens in species that differ in longevity has not been systematically examined, but a recent comparison of the exceptionally long-living naked mole-rat with the similar-sized but shorter-living mouse showed the naked mole-rat tissues to have much higher levels of plasmalogen than the mice tissues (Mitchell et al 2007).…”

Section: Longevity Variation Within Speciesmentioning

confidence: 99%

Explaining longevity of different animals: is membrane fatty acid composition the missing link?

Hulbert

2008

AGE

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Saturated and monounsaturated fatty acids are very resistant to peroxidative damage, while the more polyunsaturated a fatty acid, the more susceptible it is to peroxidation. Furthermore, the products of lipid peroxidation can oxidatively damage other important molecules. Membrane fatty acid composition is correlated with the maximum lifespans of mammals and birds. Exceptionally long-living mammal species and birds have a more peroxidation-resistant membrane composition compared to shorter-living similar-sized mammals. Within species, there are also situations in which extended longevity is associated with peroxidation-resistant membrane composition. For example, caloric restriction is associated more peroxidation-resistant membrane composition; long-living queens have more peroxidation-resistant membranes than shorter-living worker honeybees. In humans, the offspring of nonagenarians have peroxidation-resistant erythrocyte membrane composition compared to controls. Membrane fatty acid composition is a little appreciated but important correlate of the rate of aging of animals and the determination of their longevity.

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The biological significance of plasmalogens in defense against oxidative damage

Cited by 106 publications

References 37 publications

Quantitative analysis of phospholipids containing arachidonate and docosahexaenoate chains in microdissected regions of mouse brain

Quantitative analysis of phospholipids containing arachidonate and docosahexaenoate chains in microdissected regions of mouse brain

Changes in mitochondrial oxidative capacities during thermal acclimation of rainbow trout Oncorhynchus mykiss: roles of membrane proteins,phospholipids and their fatty acid compositions

Explaining longevity of different animals: is membrane fatty acid composition the missing link?

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