The biological significance of platelet volume: Its relationship to bleeding time, platelet thromboxane B2 production and megakaryocyte nuclear DNA concentration

Martin, John F.; Trowbridge, E. A.; Salmon, Geraldine; Plumb, Julie

doi:10.1016/0049-3848(83)90255-4

Cited by 441 publications

(345 citation statements)

References 18 publications

Supporting

Mentioning

327

Contrasting

Unclassified

Order By: Relevance

“…Large platelets are metabolically and enzimatically more active than small platelets. They aggregate more rapidly and release greater amounts of mediators such as thromboxane A2, serotonin and ATP [13,22]. Elevated MPV and PDW levels and low platelet count status in patients with RVT may also be a result of increased platelet consumption during the evolution of thrombosis.…”

Section: Discussıonmentioning

confidence: 99%

Value of Platelet Indices in Identifying Complete Resolution of Thrombus in Deep Venous Thrombosis Patients

Sevük

Altındağ

Bahadır

et al. 2014

Indian J Hematol Blood Transfus

View full text Add to dashboard Cite

We aimed to evaluate whether mean platelet volume (MPV) and platelet distribution width (PDW) are helpful to identify complete thrombus resolution (CTR) after acute deep venous thrombosis (DVT). Patients who had first-time episode of acute proximal DVT were included in this retrospective study. 100 patients with DVT were divided into two groups according to absence (group 1; n = 68) or presence (group 2; n = 32) of CTR on doppler ultrasonography at month 6. There were no significant difference in admission MPV and PDW levels between group 1 and group 2. MPV (p = 0.03) and PDW (p \ 0.001) levels at month 6 were significantly higher in group 1 than in group 2. CTR showed a moderate negative correlation with PDW at month 6 (q = -0.47) and a weak negative correlation with MPV at month 6 (q = -0.26). Logistic regression analysis showed that PDW (OR, 2.2; p = 0.004) at month 6 was an independent risk factor for the presence of residual venous thrombosis in DVT patients. Receiver operating characteristics analysis revealed that a 8.4 % decrease in admission MPV at month 6 provided 62 % sensitivity and 62 % specificity (AUC: 0.64) and a 15.4 % decrease in admission PDW at month 6 provided 87 % sensitivity and 94 % specificity (AUC: 0.89) for prediction of CTR in DVT patients. Percent change in admission MPV and PDW levels at month 6 may be used to identify the patients with CTR after a first episode of acute proximal DVT.

show abstract

Section: Discussıonmentioning

confidence: 99%

Value of Platelet Indices in Identifying Complete Resolution of Thrombus in Deep Venous Thrombosis Patients

Sevük

Altındağ

Bahadır

et al. 2014

Indian J Hematol Blood Transfus

View full text Add to dashboard Cite

show abstract

“…The volume-measuring apparatus consisted of a Coulter ZB particle counter coupled to an Apple II microcomputer by an analogue-to-digital convertor. The latter was designed to exclude all bimodal signals, those that were longer than 20 /tsec, and those that were in red-cell volume range 8 (beyond 25 fl). The system was calibrated with latex particles of known modal volumes, 4.25 fl and 10.65 fl, and its linearity tested with a pulse generator.…”

Section: Platelet Volume and Countmentioning

confidence: 99%

Platelet and megakaryocyte changes in cholesterol-induced experimental atherosclerosis.

Martin¹,

Slater²,

Kishk³

et al. 1985

Arteriosclerosis

View full text Add to dashboard Cite

Rabbits were fed either 2 g cholesterol in 10 ml olive oil daily with normal diet (n = 5) or normal diet alone (n = 5). After 12 weeks, the cholesterol-fed animals had developed fatty plaques involving 24% ± 4% of the surface area of the aorta; the control animals had none. Mean platelet volume was significantly smaller (p < 0.04) in the cholesterol-fed animals (4.1 ± 0.3 fl) compared with the controls (4.8 ± 0.4 fl). The heterogeneity of the average volume distributions of the two groups, characterized by the statistical parameters of the coefficient of variation, skewness, and kurtosis, was also significantly different. Platelet count was significantly higher (p < 0.001) in the cholesterol-fed group (7.48 ± 1.06 x 10" platelets/liter blood) compared to the control group (4.86 ± 0.60 x 10 11 platelets/liter blood). Mean megakaryocyte cytoplasmic volume was significantly larger (p < 0.001) in the cholesterol-fed rabbits (12,262 ± 1485 fl) compared with controls (6,814 ± 761 fl). The range of cytoplasmic volumes was also significantly increased in the cholesterol-fed rabbits. A significant (p < 0.01) increase in mean megakaryocyte nuclear volume in the cholesterol-fed animals was accompanied by a nonsignificant increase in mean nuclear DNA content: 30.2 ± 3.7 N compared with a control value of 23.6 ± 4.0 N. This evidence indicates that a high cholesterol diet in rabbits is associated with changes in platelet production from megakaryocytes as well with as the development of atherosclerosis. (Arteriosclerosis 5:604-612, November/December 1985) P latelets in vascular disease have increased reactivity in both human and animal models. 12 The cause of this increased reactivity may either be an effect of vessel wall changes on normal platelets or be related to an intrinsic change in the platelets themselves. In humans, the increased platelet reactivity has been associated with platelet size changes 1 which have been confirmed in recent studies.3 " 5 This evidence suggests that there may be alterations in platelet production in vascular disease. Two further observations support this hypothesis. Men who suffered sudden cardiac death associated with atheromatous arteries had larger megakaryocytes than a control group who died unexpectedly from unnatural causes.6 Similar large megakaryocytes, which produced larger than normal platelets, were also observed in men with acute myocardial infarction.

show abstract

“…Increased platelet volume is associated with increased platelet reactivity [9], shortened bleeding time [9], and increased platelet aggregation ex vivo [10]. Large platelets have higher thrombotic potential [11] and express higher levels of P-selectin [12] and glycoprotein IIbIIIa [13] than small platelets.…”

Section: Introductionmentioning

confidence: 99%

Mean platelet volume is a risk factor for venous thromboembolism: the Tromsø study

Brækkan¹,

Mathiesen

Njølstad

et al. 2010

Journal of Thrombosis and Haemostasis

282

252

View full text Add to dashboard Cite

Summary. Background: Platelet size, measured as mean platelet volume (MPV), is associated with platelet reactivity. MPV is increased in acute myocardial infarction, and has been identified as an independent risk factor for future myocardial infarction and stroke. Objectives: The purpose of the study was to determine the impact of platelet count and MPV on the incidence of venous thromboembolism (VTE) in a prospective, population-based study. Methods: Platelet count, MPV and baseline characteristics were registered in 25 923 subjects aged 25-96 years who participated in the Tromsø Study in 1994-1995. Incident VTE events were registered to the end of followup (1 September 2007). Results: There were 445 validated incident VTE events (1.6 per 1000 person-years), of which 186 (42%) were unprovoked, during a mean of 10.8 years of followup. Subjects with MPV ‡ 9.5 fL had a 1.3-fold [95% confidence interval (CI) 1.0-1.7] higher risk of total VTE and a 1.5-fold (95% CI 1.1-2.3) higher risk of unprovoked VTE than subjects with MPV < 8.5 fL in analyses adjusted for age, sex, smoking, body mass index, and platelet count. Increasing MPV was associated with increased risk of total VTE (P for trend = 0.09) and unprovoked VTE (P for trend = 0.03) in analyses adjusted for age and sex. There was no significant association between increasing platelet count and risk of VTE. Conclusions: An increasing MPV was identified as a predictor for VTE, in particular VTE of unprovoked origin. The present findings support the concept that platelet reactivity is important in the pathogenesis of VTE.

show abstract

The biological significance of platelet volume: Its relationship to bleeding time, platelet thromboxane B2 production and megakaryocyte nuclear DNA concentration

Cited by 441 publications

References 18 publications

Value of Platelet Indices in Identifying Complete Resolution of Thrombus in Deep Venous Thrombosis Patients

Value of Platelet Indices in Identifying Complete Resolution of Thrombus in Deep Venous Thrombosis Patients

Platelet and megakaryocyte changes in cholesterol-induced experimental atherosclerosis.

Mean platelet volume is a risk factor for venous thromboembolism: the Tromsø study

Contact Info

Product

Resources

About