The Biological Significance of Trogocytosis

Agbakwuru, Deborah; Wetzel, Scott A.

doi:10.1007/978-3-031-62036-2_5

Results and Problems in Cell Differentiation

2024

DOI: 10.1007/978-3-031-62036-2_5

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The Biological Significance of Trogocytosis

Deborah Agbakwuru,

Scott A. Wetzel

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2024

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References 268 publications

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Trogocytosis in CAR immune cell therapy: a key mechanism of tumor immune escape

Chen,

Xin,

Zhu

et al. 2024

Cell Commun Signal

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Immune cell therapy based on chimeric antigen receptor (CAR) technology platform has been greatly developed. The types of CAR immune cell therapy have expanded from T cells to innate immune cells such as NK cells and macrophages, and the diseases treated have expanded from hematological malignancies to non-tumor fields such as infectious diseases and autoimmune diseases. Among them, CAR-T and CAR-NK therapy have observed examples of rapid remission in approved clinical trials, but the efficacy is unstable and plagued by tumor resistance. Trogocytosis is a special phenomenon of intercellular molecular transfer that is common in the immune system and is achieved by recipient cells through acquisition and internalization of donor cell-derived molecules and mediates immune effects. Recently, a novel short-term drug resistance mechanism based on trogocytosis has been proposed, and the bidirectional molecular exchange between CAR immune cells and tumor cells triggered by trogocytosis partially explains the long-term relapse phenomenon after treatment with CAR immune cells. In this review, we summarize the research progress of trogocytosis in CAR immunotherapy, discuss the influencing factors of trogocytosis and its direct and indirect interference with CAR immune cells and emphasize that the interference of trogocytosis can further release the potential of CAR immune cell therapy.

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Trogocytosis in CAR immune cell therapy: a key mechanism of tumor immune escape

Chen,

Xin,

Zhu

et al. 2024

Cell Commun Signal

View full text Add to dashboard Cite

show abstract

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The Biological Significance of Trogocytosis

Cited by 1 publication

References 268 publications

Trogocytosis in CAR immune cell therapy: a key mechanism of tumor immune escape

Trogocytosis in CAR immune cell therapy: a key mechanism of tumor immune escape

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