The biologically active constituents of Ganoderma lucidum (Fr.) Karst. Histamine release-inhibitory triterpenes.

Kohda, Hiroshi; Tokumoto, Wakako; Sakamoto, Kiyoe; Fujii, Masaharu; Hirai, Yuko; Yamasaki, Kazuo; Komoda, Yasuo; Nakamura, Hideo; Ishihara, Sakiko; Uchida, Masataka

doi:10.1248/cpb.33.1367

Cited by 179 publications

(97 citation statements)

References 1 publication

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“…All these structures were fully characterized by direct comparison of their NMR and MS spectra data with those reported in the literatures [27][28][29][30][31][32][33]. Their°purities were over 95% determined by HPLC/UV analysis.…”

Section: Chemicalsmentioning

confidence: 99%

Analysis of triterpenoids in Ganoderma lucidum using liquid chromatography coupled with electrospray ionization mass spectrometry

Yang

Wang

Guan

et al. 2007

J. Am. Soc. Mass Spectrom.

136

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Triterpenoids extracted from Ganoderma lucidum (Leyss. ex Fr.) Karst were separated and characterized using optimized reversed-phase liquid chromatography with diode array detection and electrospray ion trap tandem mass spectrometry (HPLC-DAD-ESI-MS n ). They could be classified into five types depending on the fragmentation behavior. second alcohol at C-15 were oxidized to ketone, the prominent cleavage would occur at C-ring and produce a group of ions of a; if C-7 were oxidized to ketone, transference of two hydrogen atoms would occur during the cleavage of rings and a list of ions about a ϩ 2 and/or b ϩ 2 would appear instead. The above fragmentations and regularities in fragmentation pathways were reported for the first time, and were implemented for the analysis of triterpenoids in G. lucidum. The chloroform extract was separated on a Zorbax SB-C 18 column, eluting with an acetonitrile-0.2% acetic acid gradient. A total of 32 triterpenoids, including six new ones, were identified or tentatively characterized based on the tandem mass spectra of the HPLC peaks. (J Am Soc Mass Spectrom 2007, 18, 927-939)

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Section: Chemicalsmentioning

confidence: 99%

Analysis of triterpenoids in Ganoderma lucidum using liquid chromatography coupled with electrospray ionization mass spectrometry

Yang

Wang

Guan

et al. 2007

J. Am. Soc. Mass Spectrom.

136

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show abstract

“…Gray MD-fraction, ergosterol (1) Antioxidant (Wang et al, 1995(Wang et al, & 1996, hypotensive, Hypoglycemic (Horio et al, 2001), Immunotherapy (Hazama et al, 1995), Antiinflammatory activity (Zhang et al, 2002) Ganoderma lucidum (Curtis) P. Karst Ganoderan A and B, glucans, Triterpenes (ganoderiol F (2), ganodermanontriol (3), ganoderic acids (4) A, B, D, F, G, H, Z), ganosporeric acid A, ganopoly, the polysaccharide-containing preparation Hypoglycemic (Hikino et al, 1985), antioxidant and antitumor (Thekkuttuparambil et al, 2007), antiviral (HIV-1) (El-Mekkawy et al, 1998), Antiallergic (Kohda et al, 1985;Tasaka et al, 1988), Anti-inflammatory (Koyama et al, 1997), antihepatotoxic (Hirotani et al, 1986;Chen & Yu, 1993, inhibit the biosynthesis of cholesterol (Komoda et al, 1989), antioxidative and free radical scavenging effects (Lin, 2004) Ganoderma pfeifferi Bres. Sesquiterpenoid hydroquinones, ganodermadiol (5), lucidadiol (6) and applanoxidic acid G (7)…”

Section: Flammulina Velutipes (Curtis) Singermentioning

confidence: 99%

“…application (Sano et al, 2002). Some compounds from G. lucidum (ganoderic acids C and D); inhibit the histamine release from rat mast cells (Kohda et al, 1985;Tasaka et al, 1988). Eating of Tricholoma populinum J. E. Lange led to the regression of severe allergic symptoms in a patient with thromboangitis obliterans and in another patient with urticaria (Kreisel et al, 1990).…”

Section: Mushrooms As Antiallergic Agentsmentioning

confidence: 99%

Mushrooms as therapeutic agents

Rathee¹,

Rathee²,

Rathee³

et al. 2012

Rev. bras. farmacogn.

124

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Abstract:Mushrooms have been known for their nutritional and culinary values and used as medicines and tonics by humans for ages. In modern terms, they can be considered as functional foods which can provide health benefits beyond the traditional nutrients. There are monographs that cover the medicinal and healing properties of some individual traditional mushrooms. There has been a recent upsurge of interest in mushrooms not only as a health food which is rich in protein but also as a source of biologically active compounds of medicinal value which include complementary medicine/dietary supplements for anticancer, antiviral, hepatoprotective, immunopotentiating and hypocholesterolemic agents. However the mechanisms of the various health benefits of mushrooms to humans still require intensive investigation, especially given the emergence of new evidence of their health benefits. In the present paper the medicinal potential of mushrooms is being discussed.

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“…Several biological activities of this mushroom have been linked to triterpene components, 1) some of which display cytotoxic, 2) histamine release-inhibiting, 3) angiotensin converting enzyme-inhibiting, 4) and cholesterol synthesis-inhibiting effects. 5,6) However, despite their pharmacological potential, little is known about the molecular biology of triterpene biosynthesis in G. lucidum.…”

mentioning

confidence: 99%

“…10) In eukaryotes, HMGR is an integral membrane glycoprotein located in the endoplasmic reticulum. [11][12][13][14] Three distinct regions can be identified within the protein: a membrane anchor N-terminal domain that contains a number (1)(2)(3)(4)(5)(6)(7)(8) of hydrophobic regions; a C-terminal catalytic domain; and a linker region between these two domains. Comparison of the amino acid sequences of HMGRs from different organisms has revealed that the level of N-terminal similarity is relatively low, whereas C-terminal sequences are highly conserved among the different enzymes.…”

mentioning

confidence: 99%

Cloning and Characterization of a Gene Encoding HMG-CoA Reductase fromGanoderma lucidumand Its Functional Identification in Yeast

Shang

Zhu

et al. 2008

Bioscience, Biotechnology, and Biochemistry

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The biologically active constituents of Ganoderma lucidum (Fr.) Karst. Histamine release-inhibitory triterpenes.

Cited by 179 publications

References 1 publication

Analysis of triterpenoids in Ganoderma lucidum using liquid chromatography coupled with electrospray ionization mass spectrometry

Analysis of triterpenoids in Ganoderma lucidum using liquid chromatography coupled with electrospray ionization mass spectrometry

Mushrooms as therapeutic agents

Cloning and Characterization of a Gene Encoding HMG-CoA Reductase fromGanoderma lucidumand Its Functional Identification in Yeast

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