The biology of bone morphogenetic protein signaling pathway in cerebrovascular system

Abstract

Bone morphogenetic protein belongs to transcription growth factor superfamily β; bone morphogenetic protein signal pathway regulates cell proliferation, differentiation, and apoptosis among different tissues. Cerebrovascular system supplies sufficient oxygen and blood into brain to maintain its normal function. The disorder of cerebrovascular system will result into serious cerebrovascular diseases, which is gradually becoming a major threat to human health in modern society. In recent decades, many studies have revealed the underlying biology and mechanism of bone morphogenetic protein signal pathway played in cerebrovascular system. This review will discuss the relationship between the two aspects, aiming to provide new perspective for non-invasive treatment and basic research of cerebrovascular diseases.

The brain–bone axis: unraveling the complex interplay between the central nervous system and skeletal metabolism

“…The BMPs signaling pathway plays a dual role in the damage response and repair process after ischemic and hemorrhagic strokes [83]. On the one hand, the rapid increase in BMP2, BMP4, and BMP7 expression after ischemia or hemorrhage can promote astrocyte proliferation, aggravate neuroinflammation and apoptosis, and amplify brain injury.…”