The Biology of Human CD2

Reinherz, Ellis L.; Chang, Hanna; Clayton, L.K.; Gardner, Pete D.; Howard, F.D.; Koyasu, Shigeo; Jin, Yi; Moingeon, Philippe; Sayre, P.H.

doi:10.1101/sqb.1989.054.01.073

Cited by 3 publications

(1 citation statement)

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“…Next, we characterize the structure, composition, and regulation of this invagination (as displayed in Figs. [1][2][3][4][5][6]. To assess its function, one ideally would like to block its formation without impeding other features of T cell organization and T cell signaling.…”

Section: Cd2/cd48 Accumulates At the T Cell-apc Interfacementioning

confidence: 99%

A Large T Cell Invagination with CD2 Enrichment Resets Receptor Engagement in the Immunological Synapse

Singleton

Parvaze

Dama

et al. 2006

The Journal of Immunology

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T cell activation is driven by the TCR and complemented by costimulation. We have studied the dynamics of ligand-engagement of the costimulatory receptor CD2 in T cell/APC couples. Thousands of ligand-engaged CD2 molecules were included in a large T cell invagination at the center of the cellular interface within 1 min of cell couple formation. The structure and regulation of this invagination shared numerous features with phagocytosis and macropinocytosis. Three observations further characterize the invagination and the inclusion of CD2: 1) numerous ligand-engaged receptors were enriched in and internalized through the T cell invagination, none as prominently as CD2; 2) dissolution of the T cell invagination and CD2 engagement were required for effective proximal T cell signaling; and 3) the T cell invagination was uniquely sensitive to the affinity of the TCR for peptide-MHC. Based on this characterization, we speculate that the T cell invagination, aided by CD2 enrichment, internalizes parts of the TCR signaling machinery to reset T cell signaling upon agonist-mediated, stable APC contact.

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