The biology of melanocyte and melanocyte stem cell

Li, Ang

doi:10.1093/abbs/gmt145

Cited by 16 publications

(15 citation statements)

References 69 publications

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“…Melanoblasts can be distinguished from NCCs by their expression of the melanocyte differentiation markers microphthalmia-associated transcription factor (MITF), dopachrome tautomerase (DCT), KIT proto-oncogene (KIT), tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1) [ 62 ]. MITF is the first melanocyte-specific marker expressed in melanoblasts and strong expression is retained in differentiated adult melanocytes.…”

Section: Zebs During Specification From Neural Crest Cells Towardsmentioning

confidence: 99%

Intrinsic Balance between ZEB Family Members Is Important for Melanocyte Homeostasis and Melanoma Progression

Bruneel

Verstappe

Vandamme

et al. 2020

Cancers

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It has become clear that cellular plasticity is a main driver of cancer therapy resistance. Consequently, there is a need to mechanistically identify the factors driving this process. The transcription factors of the zinc-finger E-box-binding homeobox family, consisting of ZEB1 and ZEB2, are notorious for their roles in epithelial-to-mesenchymal transition (EMT). However, in melanoma, an intrinsic balance between ZEB1 and ZEB2 seems to determine the cellular state by modulating the expression of the master regulator of melanocyte homeostasis, microphthalmia-associated transcription factor (MITF). ZEB2 drives MITF expression and is associated with a differentiated/proliferative melanoma cell state. On the other hand, ZEB1 is correlated with low MITF expression and a more invasive, stem cell-like and therapy-resistant cell state. This intrinsic balance between ZEB1 and ZEB2 could prove to be a promising therapeutic target for melanoma patients. In this review, we will summarise what is known on the functional mechanisms of these transcription factors. Moreover, we will look specifically at their roles during melanocyte-lineage development and homeostasis. Finally, we will overview the current literature on ZEB1 and ZEB2 in the melanoma context and link this to the ‘phenotype-switching’ model of melanoma cellular plasticity.

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Section: Zebs During Specification From Neural Crest Cells Towardsmentioning

confidence: 99%

Intrinsic Balance between ZEB Family Members Is Important for Melanocyte Homeostasis and Melanoma Progression

Bruneel

Verstappe

Vandamme

et al. 2020

Cancers

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“…In the hair follicle, melanocyte and melanocytes stem cells numbers are maintained in a dynamic balance. In the cell cycle of the hair follicle, melanocytes proliferate during the hair growth phase and are depleted during the regression phase; the new melanocyte is produced by the differentiation and proliferation of melanocyte stem cells [37,38,39]. The Notch signaling pathway plays a key role in melanoblasts, melanocyte stem cells, keratinocytes and melanocytes [40].…”

Section: Discussionmentioning

confidence: 99%

Identification of Differentially Expressed miRNAs between White and Black Hair Follicles by RNA-Sequencing in the Goat (Capra hircus)

Cao

et al. 2014

IJMS

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MicroRNAs (miRNAs) play a key role in many biological processes by regulating gene expression at the post-transcriptional level. A number of miRNAs have been identified from livestock species. However, compared with other animals, such as pigs and cows, the number of miRNAs identified in goats is quite low, particularly in hair follicles. In this study, to investigate the functional roles of miRNAs in goat hair follicles of goats with different coat colors, we sequenced miRNAs from two hair follicles samples (white and black) using Solexa sequencing. A total of 35,604,016 reads were obtained, which included 30,878,637 clean reads (86.73%). MiRDeep2 software identified 214 miRNAs. Among them, 205 were conserved among species and nine were novel miRNAs. Furthermore, DESeq software identified six differentially expressed miRNAs. Quantitative PCR confirmed differential expression of two miRNAs, miR-10b and miR-211. KEGG pathways were analyzed using the DAVID website for the predicted target genes of the differentially expressed miRNAs. Several signaling pathways including Notch and MAPK pathways may affect the process of coat color formation. Our study showed that the identified miRNAs might play an essential role in black and white follicle formation in goats.

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“…Keempat, Wnt receptor mengaktivasi glycogen synthase kinase 3β (G5K3β) yang meningkatkan β-catekin dan lymphocyte enhancer factor (LEF)/TCA kompleks dan mengaktifkan MITF. 15 Hidrokuinon merupakan terapi yang paling banyak dipakai untuk penanganan hiperpigmentasi pada saat ini. Konsentrasi dimulai dari 2% hingga kurang dari 10% 6 dan memiliki mekanisme kerja dengan cara menghambat enzim tirosinase, merusak melanosit secara langsung, mempercepat degradasi melanosom, dan menghambat sintesis enzim melanogenesis.…”

Section: Bahasanunclassified

Krim Ekstrak Buah Merah (Pandanus conoideus ) 10% Sama Efektifnya dengan Krim Hidrokuinon 4% dalam Mencegah Peningkatan Jumlah Melanin Kulit Marmut (Cavia porcellus) yang Dipapar Sinar Ultraviolet B

Dumaria¹,

Wiraguna²,

Pangkahila³

2018

JBM

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This study was aimed to prove that administration of 10% redfruit extract cream could prevent the increase of skin melanin in guinea pig exposed to UVB and to compare this effect with 4% hydroquinone cream. This was a true experimental study using post test only control group design. Subjects were devided into three groups; each of 10 guinea pigs. Group 1, the control group, was exposed to UVB and applied with basic cream. Group 2 was exposed to UVB and applied with 4% hydroquinone cream. Group 3 was exposed to UVB and applied with 10% redfruit extract cream. The total dose of UVB was 390 mJ/cm2 given for 2 weeks. The amount of melanin was calculated using the percentage of the pixel area of melanin and was compared with the pixel areas of all epidermal tissues. The results showed that the highest percentage of melanin area was in group 1 (19.78%±3.79%). The percentage of melanin area in group 3 was 1.25%±0.76% meanwhile in group 2 was 0.85%±0.37%. There were signi-ficant differences in melanin percentage between the control group and group 2 as well as group 3 (P <0.05). There was no significant difference in melanin percentage between group 2 and group 3 (P >0.05). Conclusion: The 10% redfruit extract cream could prevent the increase of skin melanin in guinea pig exposed to UVB as effectively as the 4% hydroquinone cream.Keywords: redfruit extract cream, melanin, UVBAbstrak: Penelitian ini bertujuan untuk membuktikan efek pemberian krim ekstrak buah merah 10% dalam mencegah peningkatan jumlah melanin kulit marmut yang dipapar sinar UVB dan perbandingannya dengan krim hidrokuinon 4%. Jenis penelitian ialah eksperimental murni dengan post test only control group design. Sampel terdiri dari tiga kelompok dengan jumlah sampel 10 ekor marmut jantan tiap kelompok. Kelompok 1 yaitu kelompok kontrol, diberi paparan sinar UVB dan diolesi krim dasar. Kelompok 2 diberi paparan sinar UVB dan diolesi krim hidrokuinon 4%. Kelompok 3 diberi paparan sinar UVB dan diolesi krim ekstrak buah merah 10%. Dosis total UVB yaitu 390 mJ/cm2 diberikan selama 2 minggu. Jumlah melanin dihitung dengan persentase pixel luas area melanin dibandingkan dengan pixel seluruh jaringan epidermis. Hasil penelitian menunjukkan jumlah melanin tertinggi pada kelompok 1 (19,78± 3,79%) dan terendah pada kelompok 2 (0,85±0,37%), sedangkan jumlah melanin pada kelompok 3 di antara keduanya (1,25±0,76%). Terdapat perbedaan bermakna antara kelompok 1 dengan kelompok 2 dan 3 (P <0,05). Tidak terdapat perbedaan bermakna antara kelompok 2 dan 3 dalam mencegah peningkatan jumlah melanin (P >0,05 ). Simpulan: Krim ekstrak buah merah 10% dapat mencegah peningkatan jumlah melanin kulit marmut yang dipapar sinar UVB sama efektif dengan krim hidrokuinon 4%.Kata kunci: krim ekstrak buah merah, melanin, UVB

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The biology of melanocyte and melanocyte stem cell

Cited by 16 publications

References 69 publications

Intrinsic Balance between ZEB Family Members Is Important for Melanocyte Homeostasis and Melanoma Progression

Intrinsic Balance between ZEB Family Members Is Important for Melanocyte Homeostasis and Melanoma Progression

Identification of Differentially Expressed miRNAs between White and Black Hair Follicles by RNA-Sequencing in the Goat (Capra hircus)

Krim Ekstrak Buah Merah (Pandanus conoideus ) 10% Sama Efektifnya dengan Krim Hidrokuinon 4% dalam Mencegah Peningkatan Jumlah Melanin Kulit Marmut (Cavia porcellus) yang Dipapar Sinar Ultraviolet B

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