The Biology of Pain: Through the Rheumatology Lens

Sunzini, Flavia; Schrepf, Andrew; Clauw, Daniel J.; Basu, Neil

doi:10.1002/art.42429

Cited by 22 publications

(8 citation statements)

References 85 publications

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“…The long-term prognosis for pain is often unfavorable, even after inflammation is suppressed, and pain is associated with fatigue and psychological distress. The role of cytokines, such as TNF-α, IL-1, and IL-6, in the pathogenesis and associated pain has been well characterized …”

Section: Deciphering Persistent Pain In Rheumatoid Arthritismentioning

confidence: 99%

Unveiling Novel Drug Targets and Emerging Therapies for Rheumatoid Arthritis: A Comprehensive Review

Khokhar,

Dey,

Tomo

et al. 2024

ACS Pharmacol. Transl. Sci.

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Rheumatoid arthritis (RA) is a chronic debilitating autoimmune disease, that causes joint damage, deformities, and decreased functionality. In addition, RA can also impact organs like the skin, lungs, eyes, and blood vessels. This autoimmune condition arises when the immune system erroneously targets the joint synovial membrane, resulting in synovitis, pannus formation, and cartilage damage. RA treatment is often holistic, integrating medication, physical therapy, and lifestyle modifications. Its main objective is to achieve remission or low disease activity by utilizing a “treat-to-target” approach that optimizes drug usage and dose adjustments based on clinical response and disease activity markers. The primary RA treatment uses disease-modifying antirheumatic drugs (DMARDs) that help to interrupt the inflammatory process. When there is an inadequate response, a combination of biologicals and DMARDs is recommended. Biological therapies target inflammatory pathways and have shown promising results in managing RA symptoms. Close monitoring for adverse effects and disease progression is critical to ensure optimal treatment outcomes. A deeper understanding of the pathways and mechanisms will allow new treatment strategies that minimize adverse effects and maintain quality of life. This review discusses the potential targets that can be used for designing and implementing precision medicine in RA treatment, spotlighting the latest breakthroughs in biologics, JAK inhibitors, IL-6 receptor antagonists, TNF blockers, and disease-modifying noncoding RNAs.

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Section: Deciphering Persistent Pain In Rheumatoid Arthritismentioning

confidence: 99%

Unveiling Novel Drug Targets and Emerging Therapies for Rheumatoid Arthritis: A Comprehensive Review

Khokhar,

Dey,

Tomo

et al. 2024

ACS Pharmacol. Transl. Sci.

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“…Имеются данные о том, что высокий уровень ИЛ-6 ассоциируется с гиперпродукцией антител к ИФН-α [170]. Увеличение концентрации ИЛ-6, ИЛ-1 и ФНО при различных патологических состояниях ассоциируется с выраженностью восприятия боли, тревогой, депрессией, симптомами воспаления [278][279][280][281]. Предполагается, что гиперпродукция ИЛ-6 является фактором риска развития нейтропсихиатрических проявлений, наблюдаемых при длительном COVID [282,283].…”

Section: ингибиторы интерлейкинаunclassified

Coronavirus disease 2019 (COVID-19) pandemic and autoimmune rheumatic diseases: Outcomes and prospects

Nasonov

2024

Naučno-praktičeskaâ revmatologiâ

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The pandemic of coronavirus disease 2019 (COVID-19), etiologically related to the SARS-CoV-2 virus (severe acute respiratory syndrome coronavirus-2), has drawn attention to new clinical and fundamental problems in the immunopathology of human diseases associated with virus-induced autoimmunity and autoinflammation. The provision that “the experience gained in rheumatology in the process of studying the pathogenetic mechanisms and pharmacotherapy of immunoinflammatory rheumatic diseases as the most common and severe forms of autoimmune and autoinflammatory pathology in humans will be in demand for deciphering the nature of the pathological processes underlying COVID-19 and developing approaches to effective pharmacotherapy” was confirmed in numerous studies conducted over the next 3 years in the midst of the COVID-19 pandemic. The main focus will be on a critical analysis of data regarding the role of autoimmune inflammation, which forms the basis of the pathogenesis of immune-mediated rheumatic diseases in the context of the immunopathology of COVID-19.

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“…This may indicate the existence of pain as a condition rather than a symptom resulting from actual or potential tissue damage [10]. The idea behind the new classification system was based on findings from studies of "nonspecific" pain syndromes, such as fibromyalgia, tension-type headache (TTH), or irritable bowel syndrome (IBS) [8,11].…”

Section: Mechanisms Of Pain Formationmentioning

confidence: 99%

The effect of divided and directed attention on the magnitude of spatial summation of pain

Katra,

Adamczyk

2023

phr

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Background: Spatial summation of pain (SSp) is observed when the experienced pain intensity increases when the painful area enlarges. Despite many years of research on SSp, the effect itself and its clinical relevance are still not fully understood. Aims:This narrative review article focuses on the effect of SSp as a physiological mechanism as well as the procedure for assessing pain modulation in humans. In particular, a line of research on the moderating effect of attention on SSp is presented and discussed. Summary: So far, studies on SSp have shown promising outcomes for pain reduction and pain diagnosis in patients experiencing widespread pain. When attention manipulation procedures are used in the context of the area of pain, a hypoalgesic effect can be observed. This effect, combined with other techniques targeting the somatosensory system, can contribute to developing comprehensive sensory-discriminative training aimed at reducing pain.

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The Biology of Pain: Through the Rheumatology Lens

Cited by 22 publications

References 85 publications

Unveiling Novel Drug Targets and Emerging Therapies for Rheumatoid Arthritis: A Comprehensive Review

Unveiling Novel Drug Targets and Emerging Therapies for Rheumatoid Arthritis: A Comprehensive Review

Coronavirus disease 2019 (COVID-19) pandemic and autoimmune rheumatic diseases: Outcomes and prospects

The effect of divided and directed attention on the magnitude of spatial summation of pain

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