The biology, pathogenesis and classification of <i>Streptobacillus moniliformis</i>

Rooyen, C. E. van

doi:10.1002/path.1700430303

Cited by 28 publications

(9 citation statements)

References 12 publications

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“…turkeys (Mohamed et 01., 1969), guineapigs (Kirchner et 01., 1987), spinifex hopping mice (Notomys alexis) (Hopkinson & Lloyd, 1981), koala (Phaseolaretos cinereus) (Russell & Staube, 1979) and mice (Savage et 01., 1981;WullenweberSchmidt & Kaspareit-Rittinghausen, 1988). The mode of transmission of S. moniliformis from rats, considered the primary hosts to other animals has not been elucidated, but studies in mice (Levaditi et al, 1932;van Rooyen, 1936) and epidemiological observations in turkeys (Yamamoto & Clark, 1966) suggest that, as in man, it may be via a bite by an infected rat.…”

Section: Resultsmentioning

confidence: 99%

Isolation of Streptobacillus moniliformis from the middle ear of rats

et al. 1991

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Section: Resultsmentioning

confidence: 99%

Isolation of Streptobacillus moniliformis from the middle ear of rats

et al. 1991

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“…Among these are direct slide agglutination and complement fixation techniques with human or naturally or experimentally infected animal sera. 15,40,74,[121][122][123][124][125][126][127][128] Compared to modern methods, these tests show a flaw in sensitivity and specificity. Nevertheless, agglutinating antibodies were also used early in taxonomic studies to type S. moniliformis strains.…”

Section: Indirect Techniques For Detection Of Infectionmentioning

confidence: 99%

“…Nevertheless, agglutinating antibodies were also used early in taxonomic studies to type S. moniliformis strains. 125 A complement fixation test 74,129,130 and an indirect immunofluorescence assay (IFA) 11,27,75 have been employed in intravenously infected mice. The latter was prepared by using air-dried and heat fixed bacterial suspensions with an OD of 0.2 on IFA slides as antigen.…”

Section: Indirect Techniques For Detection Of Infectionmentioning

confidence: 99%

Approved and novel strategies in diagnostics of rat bite fever and otherStreptobacillusinfections in humans and animals

Eisenberg¹,

Ewers

Rau

et al. 2016

Virulence

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Rat bite fever (RBF), a worldwide occurring and most likely under-diagnosed zoonosis caused by Streptobacillus moniliformis, represents the most prominent disease of Streptobacillus infections. Recently, novel members have been described, from which a reservoir in rats and other animal species and a zoonotic potential can be assumed. Despite regularly published case reports, diagnostics of RBF continues to represent a 'diagnostic dilemma', because the mostly applied 16S rRNA sequence analysis may be uncertain for proper pathogen identification. Virtually nothing is known regarding prevalence in humans and animal reservoirs. For a realistic assessment of the pathogen's spread, epidemiology and virulence traits, future studies should focus on the genomic background of Streptobacillus. Full genome sequence analyses of a representative collection of strains might facilitate to unequivocally identify and type isolates. Prevalence studies using selective enrichment mechanisms may also enable the isolation of novel strains and candidate species of this neglected group of microorganisms.

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“…Agglutinating and complement fixing antibodies have been demonstrated in the sera of naturally and experimentally infected rats (Heilman, 1941(Heilman, & 1951 and mice (Nelson, 1933;van Rooyen, 1936;Savage, 1972Savage, & 1981. We report the development and use of an enzyme-linked immunosorbent assay (ELISA) for the detection of S. monilijormis antibodies in the sera of mice and rats.…”

Section: Streptobacillus Moniliformis;mentioning

confidence: 99%

“…Serological studies in naturally infected rats, measuring agglutinating antibodies, have been performed several decades ago (Heilman, 1941(Heilman, & 1951Nelson, 1933;van Rooyen, 1936), but apparently have never been introduced into the screening of laboratory animal colonies. The suitability of other serological methods which were used in mice, for the monitoring of rodent colonies, remains to be studied.…”

Section: Observations In Naturally Infected Ratsmentioning

confidence: 99%

An enzyme-linked immunosorbent assay (ELISA) for monitoring rodent colonies for Streptobacillus moniliformis antibodies

et al. 1993

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SummaryAn enzyme-linked immunosorbent assay (ELISA) to measure Streptobacillus moniliformis antibodies in mice and rats was developed. Twelve S. moniliformis strains originating from cases of rat-bite fever and Haverhill fever in man and from various rodent species, showed considerable serological relationship.The ELISA appeared specific since antibodies to S. moniliformis were absorbed by autologous and homologous antigen, but not by heterologous bacterial antigens.Acholeplasma laidlaw;; showed partial serological relationship with S. moniliformis.The ELISA was validated using experimental infections in mice and rats. These studies and observations in naturally infected feral rats, confirmed that S. moniliformis is difficult to grow on primary isolation, and that the ELISA for S. moniliformis antibodies revealed more contaminated animals than culture. Keywords: Streptobacillus moniliformis;Serology; ELISA; Mouse; Rat Streptobacillus monilijormis has been associated with rat-bite fever and Haverhill fever in humans, following a bite and contamination of food by rat urine respectively. The rat has been identified as the main reservoir of S. monilijormis and the bacterium is considered a commensal inhabitant of the nasopharynx in this species of animal. S. moni/iformis has been reported to

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The biology, pathogenesis and classification of Streptobacillus moniliformis

Cited by 28 publications

References 12 publications

Isolation of Streptobacillus moniliformis from the middle ear of rats

Isolation of Streptobacillus moniliformis from the middle ear of rats

Approved and novel strategies in diagnostics of rat bite fever and otherStreptobacillusinfections in humans and animals

An enzyme-linked immunosorbent assay (ELISA) for monitoring rodent colonies for Streptobacillus moniliformis antibodies

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