The Biology, Prevention, Diagnosis and Treatment of Dental Caries

Zero, Domenick T.; Fontana, Margherita; Martínez-Mier, E. Ángeles; Ferreira-Zandoná, Andrea G.; Ando, Masahiro; González-Cabezas, Carlos; Bayne, Stephen C.

doi:10.14219/jada.archive.2009.0355

Cited by 122 publications

(98 citation statements)

References 89 publications

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“…Cavities form when the tooth environment stays longer under demineralizing (net mineral loss) versus remineralizing (net mineral gain) conditions (Hicks et al, 2003). and flow rate, and frequency of carbohydrates consumed (Zero et al, 2009). Plaque is derived from salivary planktonic bacteria that form multicellular communities via cell-cell and cell-surface interactions.…”

Section: Introductionmentioning

confidence: 99%

Nanoscale characterization of effect of l-arginine on Streptococcus mutans biofilm adhesion by atomic force microscopy

et al. 2014

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A major aetiological factor of dental caries is the pathology of the dental plaque biofilms. The amino acid L-arginine (Arg) is found naturally in saliva as a free molecule or as a part of salivary peptides and proteins. Plaque bacteria metabolize Arg to produce alkali and neutralize glycolytic acids, promoting a less cariogenous oral microbiome. Here, we explored an alternative and complementary mechanism of action of Arg using atomic force microscopy. The nanomechanical properties of Streptococcus mutans biofilm extracellular matrix were characterized under physiological buffer conditions. We report the effect of Arg on the adhesive behaviour and structural properties of extracellular polysaccharides in S. mutans biofilms. High-resolution imaging of biofilm surfaces can reveal additional structural information on bacterial cells embedded within the surrounding extracellular matrix. A dense extracellular matrix was observed in biofilms without Arg compared to those grown in the presence of Arg. S. mutans biofilms grown in the presence of Arg could influence the production and/or composition of extracellular membrane glucans and thereby affect their adhesion properties. Our results suggest that the presence of Arg in the oral cavity could influence the adhesion properties of S. mutans to the tooth surface.

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Section: Introductionmentioning

confidence: 99%

Nanoscale characterization of effect of l-arginine on Streptococcus mutans biofilm adhesion by atomic force microscopy

et al. 2014

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“…Despite a moderate decrease in prevalence in developed countries, an increase has been observed globally [Petersen, 2003;Bagramian et al, 2009]. However, dental caries is largely preventable and can be treated by nonsurgical interventions when detected at the earliest stage of the disease [Nyvad, 2004;Zandona and Zero, 2006;Zero et al, 2009]. This represents a paradigm shift aiming to emphasize disease prevention and conservation of tooth structure [Pitts et al, 2013].…”

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confidence: 99%

In vitro Detection of Occlusal Caries on Permanent Teeth by a Visual, Light-Induced Fluorescence and Photothermal Radiometry and Modulated Luminescence Methods

et al. 2015

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Background: The paradigm shift towards the nonsurgical management of dental caries relies on the early detection of the disease. Detection of caries at an early stage is of unequivocal importance for early preventive intervention. Objective: The aim of this in vitro study is to evaluate the performance of a visual examination using the International Caries Detection and Assessment System (ICDAS) criteria, two quantitative light-induced fluorescence (QLF) systems - Inspektor™ Pro and QLF-D Biluminator™ 2 (Inspektor Research Systems B.V., Amsterdam, The Netherlands) - and a photothermal radiometry and modulated luminescence, The Canary System® (Quantum Dental Technologies, Toronto, Ont., Canada) on the detection of primary occlusal caries on permanent teeth. Methods: A total of 60 teeth with occlusal surface sites ranging from sound to noncavitated lesions (ICDAS 0-4) were assessed with each detection method twice in a random order. Histological validation was used to compare methods for sensitivity, specificity, percent correct, and the area under the receiver operating characteristic curve (AUC), at standard and optimum sound thresholds. Interexaminer agreement and intraexaminer repeatability were measured using intraclass correlation coefficients. Results: Interexaminer agreement ranged between 0.48 (The Canary System®) and 0.96 (QLF-D Biluminator™ 2). Intraexaminer repeatability ranges were 0.33-0.63 (The Canary System®) and 0.96-0.99 (QLF-D Biluminator™ 2). The sensitivity range was 0.75-0.96 while that of specificity was 0.43-0.89. The AUC were 0.79 (The Canary System®), 0.87 (ICDAS), 0.90 (Inspektor™ Pro), and 0.94 (QLF-D Biluminator™ 2). Conclusion: ICDAS had the best combination of sensitivity and specificity followed by QLF-D Biluminator™ 2 at optimum threshold.

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“…excessive consumption of which can lead to both obesity and dental caries (13). Taking into account the common risk factors of dental caries and growth indices in children, and the possible relationship between dental caries and physical development in children, the relationship between DMFT and growth indices of three-to-six-year-old children was conducted in the current study.…”

Section: Discussionmentioning

confidence: 99%

Body Mass Index and Dental Caries in Children

Bahrololoomi¹,

Ardakani²,

Ardakani³

2016

Int J School Health

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Background: Dental caries is the most common chronic childhood disease with serious implications for individual and public health. Obesity is the most common nutritional problem in children and caries are associated with a large number of negative health outcomes. Dental caries in children is reported to affects their anthropometric outcomes, but the evidence is conflicting. Objectives: Based on the differences in the findings of the studies and the possible role of obesity in the pathogenesis of dental caries, the current study aimed to investigate the relationship between body mass index (BMI) and dental caries among children aged three to six years. Methods: In this cross-sectional study, 400 children aged three to six years were selected through cluster sampling from Yazd kindergartens, Iran. Weight and height were measured using scale and tape measure, while decayed, missing, and filled teeth (DMFT) was recorded through intraoral examination using mirror, probe and flashlight. Then the relationship between calculated growth indices z-score (evaluated by world health organization (WHO) Anthro and WHO AnthroPlus software) and DMFT was considered. The results were analysed using SPSS ver. 20 and Kruskal-Wallis, Spearman correlation coefficient and Pearson tests. Results: An inverse correlation was found between BMI z-score and DMFT (P = 0.006, r = -0.14). Assessment of the effect of demographic variables showed significant relationship in boys (P = 0.01) and children under five years (P = 0.04).Conclusions: It appears that children with a high BMI z-score had lower DMFT and that there is a negative correlation between obesity and tooth decay.

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The Biology, Prevention, Diagnosis and Treatment of Dental Caries

Cited by 122 publications

References 89 publications

Nanoscale characterization of effect of l-arginine on Streptococcus mutans biofilm adhesion by atomic force microscopy

Nanoscale characterization of effect of l-arginine on Streptococcus mutans biofilm adhesion by atomic force microscopy

In vitro Detection of Occlusal Caries on Permanent Teeth by a Visual, Light-Induced Fluorescence and Photothermal Radiometry and Modulated Luminescence Methods

Body Mass Index and Dental Caries in Children

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