The Bionode

Pederson, Daniel J.; Quinkert, Christopher J; Arafat, Muhammad Abdullah; Somann, Jesse P.; Williams, Jack; Bercich, Rebecca A; Wang, Zhi; Albors, Gabriel O.; Jefferys, John G. R.; Irazoqui, Pedro P.

doi:10.1145/3301310

Cited by 22 publications

(8 citation statements)

References 33 publications

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“…All physiological measures were recorded using a custom telemeter described in (Pederson et al, 2019). ECoG was collected at 1.25 kHz, gain = 1000, passband = 3.6 -1500 Hz.…”

Section: Recordingmentioning

confidence: 99%

Mechanisms and prevention of acid reflux induced laryngospasm in seizing rats

Budde

Pederson

Biggs

et al. 2020

Epilepsy & Behavior

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Objective: Recent animal work and limited clinical data have suggested that laryngospasm may be involved in the cardiorespiratory collapse seen in sudden unexpected death in epilepsy (SUDEP). In previous work we demonstrated in an animal model of seizures that laryngospasm and sudden death were always preceded by acid reflux into the esophagus. Here, we expand on that work by testing several techniques to prevent the acid reflux or the subsequent laryngospasm. Methods:In urethane anesthetized Long Evans rats we used systemic kainic acid to acutely induce seizure activity. We recorded pH in the esophagus, respiration, electrocorticography activity, and measured the liquid volume in the stomach postmortem. We performed three interventions to attempt to prevent acid reflux or laryngospasm and gain insights into mechanisms: fasting animals for 12 hours, severing the gastric nerve, and electrical stimulation of either the gastric nerve or the recurrent laryngeal nerve.Results: Seizing animals had significantly more liquid in their stomach. Severing the gastric nerve and fasting animals significantly reduced stomach liquid volume, subsequent acid reflux, and sudden death. Laryngeal nerve stimulation can reverse laryngospasm on demand. Seizing animals are more susceptible to death from stomach-acid induced laryngospasm than non-seizing animals are to artificial-acid induced laryngospasm.

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“…All physiological measures were recorded using a custom telemeter described in (Pederson et al, 2019). ECoG was collected at 1.25 kHz, gain = 1000, passband = 3.6 -1500 Hz.…”

Section: Recordingmentioning

confidence: 99%

Mechanisms and prevention of acid reflux induced laryngospasm in seizing rats

Budde

Pederson

Biggs

et al. 2020

Epilepsy & Behavior

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“…In [ 57 ], an IWMD neuromodulation implant (bionode) is built using COTS components. To supply the required voltage to the bionode, a Texas Instruments (TI) TI7660 boost converter is used for positive output, and an inverted version of the same IC is used for negative output.…”

Section: Essential Building Blocks Of Cots-enabled Iwmdsmentioning

confidence: 99%

“…In [ 57 ], a closed-loop neuromodulation implant is presented with only COTS components. This device can record and transmit up to four channels of biopotential data while simultaneously providing biphasic constant current stimulation.…”

Section: Essential Building Blocks Of Cots-enabled Iwmdsmentioning

confidence: 99%

“…[ 64 ] presents a wireless electrophysiological recordings and optogenetic stimulation platform where an Instant Technologies COTS RHD2132 is used, which includes a fully integrated electrophysiology amplifier with an on-chip 16-bit analog-to-digital converter (ADC). In [ 57 ], the AFE features high differential input impedance, low noise, a high common mode rejection ratio (CMRR) and sufficient gain and bandwidth. It includes two parallel dual-ended AFEs where each AFE consists of passive front-end filtering followed by two gain stages.…”

Section: Essential Building Blocks Of Cots-enabled Iwmdsmentioning

confidence: 99%

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Commercial Off-the-Shelf Components (COTS) in Realizing Miniature Implantable Wireless Medical Devices: A Review

Khan

Mugisha

Tsiamis

et al. 2022

Sensors

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Over the past decade, there has been exponential growth in the per capita rate of medical patients around the world, and this is significantly straining the resources of healthcare institutes. Therefore, the reliance on smart commercial off-the-shelf (COTS) implantable wireless medical devices (IWMDs) is increasing among healthcare institutions to provide routine medical services, such as monitoring patients’ physiological signals and the remote delivery of therapeutic drugs. These smart COTS IWMDs reduce the necessity of recurring visits of patients to healthcare institutions and also mitigate physical contact, which can minimize the possibility of any potential spread of contagious diseases. Furthermore, the devices provide patients with the benefit of recuperating in familiar surroundings. As such, low-cost, ubiquitous COTS IWMDs have engendered the proliferation of telemedicine in healthcare to provide routine medical services. In this paper, a review work on COTS IWMDs is presented at a macro level to discuss the history of IWMDs, different networked COTS IWMDs, health and safety regulations of COTS IWMDs and the importance of organized procurement. Furthermore, we discuss the basic building blocks of IWMDs and how COTS components can contribute to build these blocks over widely researched custom-built application-specific integrated circuits.

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“…In [14] and [15], a fully implantable device meets all requirements, but its packaged volume and mass make it unsuitable for use in mice. In [16], a wireless neural recording system is demonstrated in freely moving mice, but it does not contain electrical stimulation capabilities and is not implantable.…”

Section: Device Development For Micementioning

confidence: 99%

A Fully Implantable Wireless Bidirectional Neuromodulation System for Mice

Wright

Wong

Mathew

et al. 2021

Preprint

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Novel research in the field of bioelectronic medicine requires systems that pair high-performance neurostimulation and bio-signal acquisition hardware with advanced software signal processing and control algorithms. Although mice are the most commonly used animal in medical research, the size, weight, and power requirements of such systems either preclude their use or impose significant constraints on experimental design. Here, we describe a fully-implantable neuromodulation system suitable for use in mice, measuring 2.2 cm3 and weighing 2.8 g. A bidirectional wireless interface allows simultaneous readout of multiple physiological signals and complete control over stimulation parameters, and a wirelessly rechargeable battery provides a lifetime of up to 5 days on a single charge. The device was successfully implanted (N=12) and a functional neural interface (capable of inducing acute bradycardia) is demonstrated with functional lifetimes exceeding to three weeks. The design utilizes only commercially-available components and 3D-printed packaging, with the goal of accelerating discovery and translation of future bioelectronic therapeutics.

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The Bionode

Cited by 22 publications

References 33 publications

Mechanisms and prevention of acid reflux induced laryngospasm in seizing rats

Mechanisms and prevention of acid reflux induced laryngospasm in seizing rats

Commercial Off-the-Shelf Components (COTS) in Realizing Miniature Implantable Wireless Medical Devices: A Review

A Fully Implantable Wireless Bidirectional Neuromodulation System for Mice

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