2023
DOI: 10.1007/s00296-023-05298-2
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The biopsychosocial impact of hypermobility spectrum disorders in adults: a scoping review

Abstract: Joint hypermobility affects approximately 30% of the United Kingdom (UK) population, characterised by the ability to move joints beyond the physiological limits. Associated conditions include Ehlers-Danlos syndrome and hypermobility spectrum disorders, affecting individuals across physical, psychological and social levels detrimentally impacting their health and wellbeing. The scoping review aims to describe the known biopsychosocial impact of joint hypermobility conditions in adults over the last decade. Addi… Show more

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Cited by 12 publications
(4 citation statements)
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“…EDS is associated with chronic pain (musculoskeletal and non-musculoskeletal), sleep disorders, mood and anxiety disorders, alongside fatigue, orthostatic intolerance, and functional gastrointestinal disorders [19,[28][29][30]. Specifically, in terms of non-musculoskeletal pain, headache is frequently reported in those with EDS [5,28,30]. Additionally, comorbidities in EDS overlap with comorbidities in adolescent headaches (i.e., depression, anxiety, and sleep disorders).…”
Section: Discussionmentioning
confidence: 99%
“…EDS is associated with chronic pain (musculoskeletal and non-musculoskeletal), sleep disorders, mood and anxiety disorders, alongside fatigue, orthostatic intolerance, and functional gastrointestinal disorders [19,[28][29][30]. Specifically, in terms of non-musculoskeletal pain, headache is frequently reported in those with EDS [5,28,30]. Additionally, comorbidities in EDS overlap with comorbidities in adolescent headaches (i.e., depression, anxiety, and sleep disorders).…”
Section: Discussionmentioning
confidence: 99%
“…Here, it is important to highlight the neuropathic bases of pain maintenance [ 3 ] by injury or disease of the somatosensory nervous system [ 41 ]. By the third or fourth decade of its natural evolution associated with various symptoms (third phase), it is observed that the condition of chronic pain, already well established, can lead to mental and cognitive impairment, with more defined states of catastrophizing and fear of pain [ 40 , 42 ]. This is characterized by nociplastic pain, ie, the painful condition originating from altered nociception, even though there is no clear evidence of actual or threatened tissue damage causing activation of peripheral nociceptors or evidence of disease or injury of the somatosensory system causing pain [ 41 ].…”
Section: Chronic Pain In Joint Hypermobilitymentioning
confidence: 99%
“…Current research suggests a key distinguishing factor between healthy and disease-related fatigue is the inability to alleviate fatigue with rest [19]. Fatigue often occurs as a comorbidity alongside various psychophysical factors, such as anxiety, depression, and pain, as demonstrated by multivariate analyses [20][21][22][23][24][25][26]. Therefore, exploring the influence of these co-factors on infertility is vital.…”
Section: Epidemiology Of Fatiguementioning
confidence: 99%