The Biosynthesis and Applications of Protein Lipidation
Wenlong Ding,
Jiayu Gu,
Wenyuan Xu
et al.
Abstract:Protein lipidation dramatically affects protein structure, localization, and trafficking via remodeling protein−membrane and protein−protein interactions through hydrophobic lipid moieties. Understanding the biosynthesis of lipidated proteins, whether natural ones or mimetics, is crucial for reconstructing, validating, and studying the molecular mechanisms and biological functions of protein lipidation. In this Perspective, we first provide an overview of the natural enzymatic biosynthetic pathways of protein … Show more
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