The Biosynthesis of the Actinomycins and its Relationship to Protein Synthesis**This investigation was aided by a U.S. Public Health Service Grant (CA-06926) from the National Cancer Institute, National Institutes of Health and the American Medical Association Educational Research Foundation (AMA ERF-128).

Katz, Edward; Weissbach, Herbert

doi:10.1016/b978-0-12-395524-1.50019-9

Biogenesis of Antibiotic Substances 1965

DOI: 10.1016/b978-0-12-395524-1.50019-9

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The Biosynthesis of the Actinomycins and its Relationship to Protein Synthesis**This investigation was aided by a U.S. Public Health Service Grant (CA-06926) from the National Cancer Institute, National Institutes of Health and the American Medical Association Educational Research Foundation (AMA ERF-128).

Edward Katz

Herbert Weissbach

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1969

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Biosynthesis of the Actinomycin Chromophore: Incorporation of 3-Hydroxy-4-Methylanthranilic Acid into Actinomycins by Streptomyces antibioticus

1969

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Actinomycin synthesis by washed mycelia of Streptomyces antibioticus has been conducted in the presence of 3-hydroxy-4-methylanthranilate-(carboxyl-l4C). Incorporation of this compound into actinomycins has been observed, which constitutes further evidence that 3-hydroxy-4-methylanthranilate is an intermediate in actinomycin biosynthesis. The position of the incorporated label has been determined to be within the actinomycin chromophore, and the label appears to be equally distributed between both halves of the chromophore. Incidental to these findings was the observation that the "4C-labeled actinomycins were subject to rapid reabsorption by the organism with actinomycin V taken up preferentially to actinomycin IV.

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Biosynthesis of the Actinomycin Chromophore: Incorporation of 3-Hydroxy-4-Methylanthranilic Acid into Actinomycins by Streptomyces antibioticus

1969

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Cited by 1 publication

References 87 publications

Biosynthesis of the Actinomycin Chromophore: Incorporation of 3-Hydroxy-4-Methylanthranilic Acid into Actinomycins by Streptomyces antibioticus

Biosynthesis of the Actinomycin Chromophore: Incorporation of 3-Hydroxy-4-Methylanthranilic Acid into Actinomycins by Streptomyces antibioticus

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