The blockade of transient receptor potential ankyrin 1 (TRPA1) protects against PTZ-induced seizure

Transient receptor potential (TRP) channels are sensors for a variety of cellular and environmental signals. Mammals express a total of 28 different TRP channel proteins, which can be divided into seven subfamilies based on amino acid sequence homology: TRPA (Ankyrin), TRPC (Canonical), TRPM (Melastatin), TRPML (Mucolipin), TRPN (NO-mechano-potential, NOMP), TRPP (Polycystin), TRPV (Vanilloid). They are a class of ion channels found in numerous tissues and cell types and are permeable to a wide range of cations such as Ca2+, Mg2+, Na+, K+, and others. TRP channels are responsible for various sensory responses including heat, cold, pain, stress, vision and taste and can be activated by a number of stimuli. Their predominantly location on the cell surface, their interaction with numerous physiological signaling pathways, and the unique crystal structure of TRP channels make TRPs attractive drug targets and implicate them in the treatment of a wide range of diseases. Here, we review the history of TRP channel discovery, summarize the structures and functions of the TRP ion channel family, and highlight the current understanding of the role of TRP channels in the pathogenesis of human disease. Most importantly, we describe TRP channel-related drug discovery, therapeutic interventions for diseases and the limitations of targeting TRP channels in potential clinical applications.

show abstract

“… 463 In contrast, HC030031 (a TRPA1 antagonist) promotes anticonvulsant effects, and preventes TRPA1 upregulation during seizures. 464 …”

Section: Physiological Functions Of Trp Channelsmentioning

confidence: 99%

TRP (transient receptor potential) ion channel family: structures, biological functions and therapeutic interventions for diseases

Zhang

et al. 2023

Sig Transduct Target Ther

119

View full text Add to dashboard Cite

show abstract

The role of transient receptor potential (TRP) channels in phagocytosis: A comprehensive review

Alavi,

Soheili,

Roohbakhsh

2024

European Journal of Pharmacology

View full text Add to dashboard Cite

Cannabinoid treatments in epilepsy and seizure disorders

Devinsky,

Jones,

Cunningham

et al. 2024

Physiological Reviews

View full text Add to dashboard Cite

Cannabis was used to treat convulsions and other disorders since ancient times. In the last few decades, preclinical animal studies and clinical investigations have established the role of cannabidiol (CBD) in treating epilepsy and seizures and support potential therapeutic benefits for cannabinoids in other neurological and psychiatric disorders. Here, we comprehensively review the role of cannabinoids in epilepsy. We briefly review the diverse physiological processes mediating the central nervous system response to cannabinoids, including D9-THC, cannabidiol, and terpenes. Next, we characterize the anti- and proconvulsive effects of cannabinoids from animal studies of acute seizures and chronic epileptogenesis. We then review the clinical literature on using cannabinoids to treat epilepsy, including anecdotal evidence and case studies as well as the more recent randomized-controlled clinical trials that led to FDA approval of CBD for some types of epilepsy. Overall, we seek to evaluate our current understanding of cannabinoids in epilepsy and focus future research on unanswered questions.

show abstract

The blockade of transient receptor potential ankyrin 1 (TRPA1) protects against PTZ-induced seizure

Cited by 3 publications

References 38 publications

TRP (transient receptor potential) ion channel family: structures, biological functions and therapeutic interventions for diseases

TRP (transient receptor potential) ion channel family: structures, biological functions and therapeutic interventions for diseases

The role of transient receptor potential (TRP) channels in phagocytosis: A comprehensive review

Cannabinoid treatments in epilepsy and seizure disorders

Contact Info

Product

Resources

About