The blood‐brain barrier — the effect of acidic dissociation constant on the permeation of certain sulfonamides into the brain

Goldsworthy, Patrick D.; Aird, Robert B.; Becker, Ronald A.

doi:10.1002/jcp.1030440311

Cited by 14 publications

(1 citation statement)

References 6 publications

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“…The small concentrations of sulphacetamide in the brain of normal mice are consistent with previous findings in the rat (Goldsworthy, Aird & Becker, 1954;Nadeau & Marchand, 1975). However, contrary to these last observations, sulphacetamide concentration in the brain of control mice remained constant throughout the experimental periods whereas there was progressive accumulation of the drug in the brain of leukaemic mice.…”

Section: Discussionsupporting

confidence: 91%

The Distribution and Kinetics of Sulphacetamide in Leukaemic Mice

Marchand

Nadeau

1976

British J Pharmacology

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During the first 90 min following oral administration of sulphacetamide, there was a rapid decline in plasma drug concentration in control mice whereas a progressive increase in sulphacetamide concentration was observed in leukaemic mice. Similar changes in the kinetics of sulphacetamide distribution were observed in the liver, spleen and muscle. While the concentration of sulphacetamide remained quite constant in the brain and fat tissue of control mice, a progressive increase in drug concentration was observed in the brain and fat tissue of leukaemic mice. Some of these changes in the kinetics of sulphacetamide tissue distribution are compatible with delay in gastrointestinal absorption of the drug and its accumulation in the ascitic fluid.

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Section: Discussionsupporting

confidence: 91%