2003
DOI: 10.1002/bies.10360
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The blood coagulation system as a molecular machine

Abstract: The human blood coagulation system comprises a series of linked glycoproteins that upon activation induce the generation of downstream enzymes ultimately forming fibrin. This process is primarily important to arrest bleeding (hemostasis). Hemostasis is a typical example of a molecular machine, where the assembly of substrates, enzymes, protein cofactors and calcium ions on a phospholipid surface markedly accelerates the rate of coagulation. Excess, pathological, coagulation activity occurs in “thrombosis”, the… Show more

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Cited by 144 publications
(110 citation statements)
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References 73 publications
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“…The haemostatic-coagulation system is the first line of defence against trauma, and it is finely tuned to prevent excessive bleeding or thrombosis (1). It is a complex but highly regulated system designed to stabilise the free flow of blood and blood constituents while also preserving the integrity of the vasculature.…”
Section: Introductionmentioning
confidence: 99%
“…The haemostatic-coagulation system is the first line of defence against trauma, and it is finely tuned to prevent excessive bleeding or thrombosis (1). It is a complex but highly regulated system designed to stabilise the free flow of blood and blood constituents while also preserving the integrity of the vasculature.…”
Section: Introductionmentioning
confidence: 99%
“…It is a complex process influenced by coagulation and fibrinolytic pathways [9,10], inflammation [11], and hypercholesterolemic state [12]. The first line of evidence supporting the anti-thrombotic effect of HO-1 in vivo is the observation that CO suppressed vascular thrombosis occurring during the cardiac graft rejection likely through inhibiting platelet aggregation [13].…”
Section: Introductionmentioning
confidence: 99%
“…By binding to activated factor VIIa, TF initiates the extrinsic coagulation pathway. 12 Thrombomodulin (TM) is normally expressed on the endothelial cell surface, where it mediates the activation of the anticoagulant protein C. 13 Tissue plasminogen activator (tPA) converts plasminogen to plasmin, which lyses clots. 14 The activity of tPA is inhibited by binding to plasminogen activator inhibitor type 1 (PAI-1), which is also constitutively secreted by the endothelium.…”
mentioning
confidence: 99%