The Blood Flow of Rabbits' Tendons:<i>Variation with Age, Activity and Hypoxia</i>

Landi, Andrea; Elves, Michael W.; Piaggi, W

doi:10.3109/17453678308992917

Cited by 14 publications

(3 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In recent years, the topic of tendon nutrition (Manske and Lesker 1982;1985) and blood supply (Brockis 1953;Bergljung 1968;Chaplin 1973;Lundborg 1979;Armenta and Lehrman 1980;Piaggi and Mingione 1981;Zbrodowski, Gajisin and Grodecki 1981;1982;Azar, Culver and Fleegler 1983;Gajisin, Abrodowski and Grodecki 1983;Landi, Elves and Piaggi 1983;Hooper, Davies and Tothill 1984) has gained increased emphasis in the medical literature, in particular with regard to surgery and post operative care of the traumatised human digital flexor tendon. The basic principles of nutritional supply and anatomic design have been described in a number of animal models (Bergljung 1968;Chaplin 1973;Manske and Lesker 1982;Landi el al 1983;Kain et a1 1988).…”

Section: Discussionmentioning

confidence: 99%

Preliminary studies on the vascular anatomy of the equine superficial digital flexor tendon

Kraus-Hansen

Fackelman

Becker

et al. 1992

Equine Veterinary Journal

View full text Add to dashboard Cite

Summary The vascular and microvascular anatomy of normal equine superficial digital flexor tendons was studied by dissection of vinyl‐perfused specimens and by microangiography on high detail film. The presence of an extensive intratendinous vascular latticework was confirmed, and a ‘nutrient artery’ described closely associated with the accessory ligament of the superficial digital flexor tendon (proximal check ligament). Circumferential stripping of the paratenon from the tendon to eliminate afferent vessels was performed bilaterally in three horses and unilaterally in a fourth, followed by a treadmill training regimen. No resulting intratendinous lesions could be documented on gross post mortem and histological examination at three, 10, or 35 days post operatively. There was mild paratendinous proliferation in all instances. In one horse, four intratendinous ligatures were placed within the medial and lateral borders of the contralateral tendon to isolate further from its blood supply a 10 cm segment. Gross lesions at 35 days post operatively included a marked paratendinous response involving the entire 10 cm segment, and a darkened, soft focus within the core of the tendon. Histopathology and electron microscopy demonstrated focal degeneration. It was concluded that the blood supply of the normal equine superficial digital flexor tendon is primarily intratendinous, rather than paratendinous as previously thought. The lesions in one horse similar to those in naturally occurring tendinitis supported a vascular aetiology of the disease, and set the groundwork for studies aimed at the development of a clinically relevant tendinitis model.

show abstract

Section: Discussionmentioning

confidence: 99%

Preliminary studies on the vascular anatomy of the equine superficial digital flexor tendon

Kraus-Hansen

Fackelman

Becker

et al. 1992

Equine Veterinary Journal

View full text Add to dashboard Cite

show abstract

“…The terminal angiograms confirmed that these elevated absolute temperature patterns correlated anatomically with the sites of hypervascularity. 6 All of the data used to generate rewarm curves were also used to determine the rewarm rates (slopes) for every site and observation period. Exponential, linear, logarithmic, and first-order quadratic fits were examined.…”

Section: Quantitative Analysis Of Transient Thermogramsmentioning

confidence: 99%

A Comparison of Steady State and Transient Thermography Techniques Using a Healing Tendon Model

et al. 1988

View full text Add to dashboard Cite

Steady state and transient thermal techniques were used to define the thermal signatures of surgically sectioned and sham-operated common calcanean tendons in four dogs. All limbs were imaged from the lateral side using an Inframetrics 525 system at - 1, 2, 4, 6, and 8 weeks after surgery. Individual video frames were used to compute absolute surface temperatures and rewarm curves for five predetermined 1 cm2 skin areas. Angiography was performed at each observation period to correlate changes in vascular morphology and thermal data. Thermal signatures and angiograms were similar in all animals before surgery. At 2 and 4 weeks after surgery, the absolute surface temperatures of the entire lateral crus area were elevated in three of four animals. During weeks 6 and 8, the surface temperatures, rewarm curves, and angiograms returned to presurgical values for the controls. Skin areas over the repaired tendons remained warmer and were shown to correlate with vascular proliferation by transient but not steady state techniques. Steady state and transient thermal imaging techniques can be used to detect vascular changes in the area around a healing tendon. However, our data indicate that transient thermal techniques are more suitable than steady state methods for localizing vascular disturbances in tissues. Thermographic imaging techniques may become a reliable noninvasive method to monitor wound healing processes if starting temperatures, cool down techniques, and time intervals for data collection are fully evaluated in future studies using transient thermal imaging protocols.

show abstract

“…An early human study reported a reduction of vascularity in the supraspinatus tendons with age (aged 20-70 years) (Brewer, 1979). While there was no change in the rate of blood flow in the flexor tendons with age in a rabbit study (Landi et al, 1983), there was a significant decrease in blood flow in the intratendinous region of rotator cuff of elderly subjects compared with younger subjects (Funakoshi et al, 2010). Rudzki et al (2008) reported a significant decrease in blood flow in intact supraspinatus tendon in asymptomatic subjects older than 40 years compared with younger subjects after exercise.…”

Section: Structural Changesmentioning

confidence: 95%

Biology of Tendon Stem Cells and Tendon in Aging

Lui

Wong

2020

Front. Genet.

View full text Add to dashboard Cite

Both tendon injuries and tendinopathies, particularly rotator cuff tears, increase with tendon aging. Tendon stem cells play important roles in promoting tendon growth, maintenance, and repair. Aged tendons show a decline in regenerative potential coupled with a loss of stem cell function. Recent studies draw attention to aging primarily a disorder of stem cells. The micro-environment ("niche") where stem cells resided in vivo provides signals that direct them to metabolize, self-renew, differentiate, or remain quiescent. These signals include receptors and secreted soluble factors for cellcell communication, extracellular matrix, oxidative stress, and vascularity. Both intrinsic cellular deficits and aged niche, coupled with age-associated systemic changes of hormonal and metabolic signals can inhibit or alter the functions of tendon stem cells, resulting in reduced fitness of these primitive cells and hence more frequent injuries and poor outcomes of tendon repair. This review aims to summarize the biological changes of aged tendons. The biological changes of tendon stem cells in aging are reviewed after a systematic search of the PubMed. Relevant factors of stem cell aging including cellintrinsic factors, changes of microenvironment, and age-associated systemic changes of hormonal and metabolic signals are examined, with findings related to tendon stem cells highlighted when literature is available. Future research directions on the aging mechanisms of tendon stem cells are discussed. Better understanding of the molecular mechanisms underlying the functional decline of aged tendon stem cells would provide insight for the rational design of rejuvenating therapies.

show abstract

The Blood Flow of Rabbits' Tendons:Variation with Age, Activity and Hypoxia

Cited by 14 publications

References 11 publications

Preliminary studies on the vascular anatomy of the equine superficial digital flexor tendon

Preliminary studies on the vascular anatomy of the equine superficial digital flexor tendon

A Comparison of Steady State and Transient Thermography Techniques Using a Healing Tendon Model

Biology of Tendon Stem Cells and Tendon in Aging

Contact Info

Product

Resources

About