The Blood Grouping Systems of Dogs

Swisher, Scott N.; Young, Lawrence E.

doi:10.1152/physrev.1961.41.3.495

Cited by 115 publications

(121 citation statements)

References 0 publications

Supporting

Mentioning

112

Contrasting

Unclassified

Order By: Relevance

“…Nevertheless, care must be taken during pretransfusion procedures in canine females, since neonatal isoerythrolysis occurs in DEA 1-positive pups when DEA 1-negative bitches immunized with IV injections of DEA 1-positive RBC and mated with DEA 1-positive sires. The fact was not observed on DEA 4-positive puppies born from DEA 4-negative bitches immunized against DEA 4 by blood transfusions (Young et al 1951, Swisher & Young 1961.…”

Section: Resultsmentioning

confidence: 85%

Frequencies of DEA blood types in a purebred canine blood donor population in Porto Alegre, RS, Brazil

et al. 2011

View full text Add to dashboard Cite

RESUMO.-[Frequências dos tipos sanguíneos do sistema DEA em uma população de cães de raça doadores de sangue em Porto Alegre, RS.] O estudo da imunohematologia canina é muito importante para a medicina veterinária transfusional. O objetivo deste estudo foi determinar as frequências dos tipos sanguíneos do sistema DEA em uma população de cães de raça que fazem parte de um programa de cães doadores de sangue em Porto Alegre, RS, Brasil. Cem cães saudáveis de raça pura foram selecionados, vinte de cada raça (Dogue Alemão, Rottweiler, Golden Retriever, Pastor Alemão e Dogo Argentino). Amostras de sangue foram coletadas em tubos contendo ACD-A e o teste de hemaglutinação em tubo de ensaio da MSU (MI, EUA) foi utilizado para determinar os tipos sanguíneos. A população estudada apresentou frequências gerais de 61% para DEA 1.1, 22% para DEA 1.2, 7% para DEA 3, 100% para DEA 4, 9% para DEA 5 and 16% para DEA 7. Uma associação significativa foi encontrada entre as raças e certas combinações de tipos sanguíneos nesta população. Os resultados estão de acordo com a literatura, visto que a maioria da população canina estudada foi positiva para DEA 1. The study of canine immunohematology is very important for veterinary transfusion medicine. The objective of this study was to determine the DEA blood type frequencies in a purebred canine blood donor population from Porto Alegre, RS, Brazil. One hundred clinically healthy purebred dogs were chosen, 20 dogs from each breed (Great Dane, Rottweiler, Golden Retriever, German Shepherd and Argentine Dogo). Blood samples were taken in ACD-A tubes and the MSU hemagglutination tube test (MI, USA) was used to determine the blood types. The studied population presented general frequencies of 61% for DEA 1.1, 22% for DEA 1.2, 7% for DEA 3, 100% for DEA 4, 9% for DEA 5 and 16% for DEA 7. A significant association was found between breeds and certain combinations of blood types in this population. The results are in agreement with the literature since most part of the canine population studied was positive for DEA 1.1, the most antigenic blood type in dogs. Differences were found among the studied breeds and those should be considered when selecting a blood donor. The knowledge of blood types frequencies and their combinations in different canine populations, including different breeds, is important because it shows the particularities of each group, helps to keep a data bank of local frequencies and minimizes the risks of transfusion reactions.

show abstract

Section: Resultsmentioning

confidence: 85%

Frequencies of DEA blood types in a purebred canine blood donor population in Porto Alegre, RS, Brazil

et al. 2011

View full text Add to dashboard Cite

show abstract

“…However, it is likely that some of the weakly DEA 1+ (including DEA 1.2+) dogs were typed as DEA 1− in the past which could have affected blood compatibility. Because it has been suggested that DEA 1− dogs will mount immune responses against weakly DEA 1+ erythrocytes, we recommend classifying any weakly to moderately DEA 1+ donor dog as DEA 1+ 16. In addition, it is advisable to transfuse weakly DEA 1+ dogs with DEA 1− blood, as it is yet unclear if weakly DEA 1+ dogs could mount an alloantibody response when given strongly DEA 1+ erythrocytes.…”

Section: Discussionmentioning

confidence: 99%

DEA1 Expression on Dog Erythrocytes Analyzed by Immunochromatographic and Flow Cytometric Techniques

Acierno

Raj

Giger

2014

Veterinary Internal Medicne

View full text Add to dashboard Cite

BackgroundThe Dog erythrocyte antigen (DEA) 1 blood group system was thought to contain types DEA 1.1 and 1.2 (and possibly 1.3 [A3]). However, DEA 1.2+ dogs are very rare and newer typing methods reveal varying degrees of DEA 1 positivity.ObjectivesTo assess if variation in DEA 1 positivity is because of quantitative differences in surface antigen expression. To determine expression patterns in dogs over time and effects of blood storage (4°C). To evaluate DEA 1.2+ samples by DEA 1 typing methods.AnimalsAnticoagulated blood samples from 66 dogs in a research colony and from a hospital, and 9 previously typed DEA 1.2+ dogs from an animal blood bank.MethodsResearch study: Samples were analyzed by flow cytometry and immunochromatographic strip using a monoclonal anti‐DEA 1 antibody.ResultsTwenty dogs were DEA 1−, whereas 46 dogs were weakly to strongly DEA 1+. Antigen quantification revealed excellent correlation between strip and flow cytometry (r = 0.929). Both methods reclassified DEA 1.2+ samples as weakly to moderately DEA 1+, but they were not retyped with the polyclonal anti‐DEA 1.1/1.X antibodies. Dogs and blood samples retained their relative DEA 1 antigen densities over time.Conclusions and Clinical ImportanceThe blood group system DEA 1 is a continuum from negative to strongly positive antigen expression. Previously typed DEA 1.2+ appears to be DEA 1+. These findings further the understanding of the DEA 1 system and suggest that all alleles within the DEA 1 system have a similarly based epitope recognized by the monoclonal antibody.

show abstract

“…In some experiments donor dogs were selected by cross-matching their blood with that of the prospective experimental dogs. This procedure proved unnecessary, presumably because naturally occurring isoantibodies are very weak in the dog (8). The packed cells were washed Circulation Rttearch, Vol XXXIV, January 1974 repeatedly with sterile saline in several experiments, but no detectable difference in experimental results occurred.…”

Section: Protocolsmentioning

confidence: 99%

Effect of Hematocrit and Colloid-Induced Changes in Blood Viscosity on Renal Hemodynamics and Renin Release in the Dog

KMMcDonald

1974

Circulation Research

View full text Add to dashboard Cite

This study compared the effects on the kidney of two major determinants of blood viscosity, the hematocrit and the plasma colloid content. In anesthetized dogs, blood viscosity was raised 30% by increasing hematocrit or infusing isoncotic Dextran 500 while blood volume was kept constant. Neither form of hyperviscosity altered blood pressure, but both forms caused a decrease of about 35% in cardiac output and a comparable rise in total peripheral resistance. Renal blood flow decreased minimally (<10%) in the group of dogs with increased hematocrit but fell more than 30% in the group given Dextran 500. Reciprocal changes occurred in renal vascular resistance. The increase in hematocrit was accompanied by an increase in renin secretion from 146 units/min to 416 units/min (P< 0.001), but Dextran 500 caused a decrease from 167 units/min to 107 units/min (P< 0.025). Sodium and potassium excretion both decreased similarly in the two groups. The data suggest that increased hematocrits are accompanied by renal vasodilatation so that renal vascular resistance rises less than blood viscosity. Dextran hyperviscosity, however, causes no compensatory vasodilatation. This difference in renal vascular response might explain the difference in renin secretion; afferent arteriolar dilatation might stimulate renin release during a rise in hematocrit, and the absence of vasodilatation in colloid hyperviscosity might explain its failure to stimulate renin. KEY WORDS plasma colloid hyperviscosity sodium excretion blood rheology dextran systemic hemodynamics• One of the well-documented responses to renal artery constriction is an increase in renin secretion by the kidney (1, 2). This observation implies that the mechanisms controlling renin secretion are responsive to changes in renal vascular resistance, although how the response is mediated is still a source of controversy (3, 4). Blood vessel diameter is of prime importance in determining flow resistance, but another determinant, blood viscosity, also contributes significantly to resistance, as predicted by the Poiseuille equation. The question arises, therefore, whether changes in blood viscosity might also influence renin secretion.Whole blood viscosity is determined chiefly by the hematocrit and the colloidal components of plasma (5). In a recent preliminary report, McDonald and Smith (6) 112 in renin secretion. The present study was designed to examine the mechanisms mediating this response and to compare it with the effects of colloid-induced hyperviscosity. In one group of dogs the hematocrit was increased, and the magnitude of the resulting rise in blood viscosity was measured by cone-plate viscometry. In another group of dogs similar changes in viscosity were produced by infusing high-molecular weight dextran, while blood volume and hematocrit were kept constant. This procedure allowed a comparison to be made between the effects of hematocrit-induced and colloid-induced changes in blood rheology on renin secretion, renal hempdynamics, and sodium excretion. MethodsMo...

show abstract

The Blood Grouping Systems of Dogs

Cited by 115 publications

References 0 publications

Frequencies of DEA blood types in a purebred canine blood donor population in Porto Alegre, RS, Brazil

Frequencies of DEA blood types in a purebred canine blood donor population in Porto Alegre, RS, Brazil

DEA1 Expression on Dog Erythrocytes Analyzed by Immunochromatographic and Flow Cytometric Techniques

Effect of Hematocrit and Colloid-Induced Changes in Blood Viscosity on Renal Hemodynamics and Renin Release in the Dog

Contact Info

Product

Resources

About