The Blood Oxygen Level–Dependent Functional MR Imaging Signal Can Be Used to Identify Brain Tumors and Distinguish Them from Normal Tissue

Feldman, Susan C.; Chu, David; Schulder, Michael; Barry, Michael A.; Cho, E.-S.; Liu, W.-C.

doi:10.3174/ajnr.a1326

Cited by 28 publications

(29 citation statements)

References 34 publications

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“…Our findings seem to concur with the hypothesis that abnormal tumor neovasculature, a pathologic hallmark of GBMs, contributes to neurovascular uncoupling, which might lead to a decrease in BOLD functional MR imaging activation at the ipsilateral hemisphere (14,18,19,27). Yet, we draw attention to the fact that the significant interhemispheric difference in BOLD functional MR imaging activation observed in GBMs, but not within metastases and meningiomas, does not prove per se that there is a difference in this respect between the three tumor types.…”

Section: Neuroradiology: Influence Of Tumor Type and Bold Functional supporting

confidence: 90%

“…Finally, the other MR imaging features examined, volume of enhancement and tumor location, did not seem to play a role. The explanation may be that BOLD response is inherently a vascular phenomenon, which is marginally affected by tumor size (18,27). However, this should be interpreted with caution, as the exact determination of tumor volumes at routine MR imaging is difficult in gliomas, in which borders are often ill defined (30).…”

Section: Neuroradiology: Influence Of Tumor Type and Bold Functional mentioning

confidence: 99%

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Brain Tumors: The Influence of Tumor Type and Routine MR Imaging Characteristics at BOLD Functional MR Imaging in the Primary Motor Gyrus

Abreu¹,

Peck²,

Petrovich-Brennan³

et al. 2016

Radiology

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Purpose:To evaluate the effects of histologic features and anatomic magnetic resonance (MR) imaging characteristics of brain tumors on the functional MR imaging signal in the primary motor cortex (PMC), as false-negative blood oxygen leveldependent (BOLD) functional MR imaging activation can limit the accurate localization of eloquent cortices. Materials andMethods:Institutional review board approval was obtained, and informed consent was waived for this HIPAA-compliant retrospective study. Conclusion:BOLD functional MR imaging activation in the ipsilateral PMC is influenced by tumor type and is significantly reduced in GBMs. FLAIR abnormality correlates moderately with the activation ratios in metastases and meningiomas.q RSNA, 2016

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Section: Neuroradiology: Influence Of Tumor Type and Bold Functional supporting

confidence: 90%

Section: Neuroradiology: Influence Of Tumor Type and Bold Functional mentioning

confidence: 99%

Brain Tumors: The Influence of Tumor Type and Routine MR Imaging Characteristics at BOLD Functional MR Imaging in the Primary Motor Gyrus

Abreu¹,

Peck²,

Petrovich-Brennan³

et al. 2016

Radiology

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“…BOLD imaging was also used in patients with brain tumors during a given task and during rest (resting-state fMRI), to study brain activation and to distinguish tumoral from non-tumoral tissue [12], [13].…”

Section: Introductionmentioning

confidence: 99%

Hemodynamic Response Imaging: A Potential Tool for the Assessment of Angiogenesis in Brain Tumors

et al. 2012

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Blood oxygenation level dependence (BOLD) imaging under either hypercapnia or hyperoxia has been used to study neuronal activation and for assessment of various brain pathologies. We evaluated the benefit of a combined protocol of BOLD imaging during both hyperoxic and hypercapnic challenges (termed hemodynamic response imaging (HRI)). Nineteen healthy controls and seven patients with primary brain tumors were included: six with glioblastoma (two newly diagnosed and four with recurrent tumors) and one with atypical-meningioma. Maps of percent signal intensity changes (ΔS) during hyperoxia (carbogen; 95%O2+5%CO2) and hypercapnia (95%air+5%CO2) challenges and vascular reactivity mismatch maps (VRM; voxels that responded to carbogen with reduced/absent response to CO2) were calculated. VRM values were measured in white matter (WM) and gray matter (GM) areas of healthy subjects and used as threshold values in patients. Significantly higher response to carbogen was detected in healthy subjects, compared to hypercapnia, with a GM/WM ratio of 3.8 during both challenges. In patients with newly diagnosed/treatment-naive tumors (n = 3), increased response to carbogen was detected with substantially increased VRM response (compared to threshold values) within and around the tumors. In patients with recurrent tumors, reduced/absent response during both challenges was demonstrated. An additional finding in 2 of 4 patients with recurrent glioblastoma was a negative response during carbogen, distant from tumor location, which may indicate steal effect. In conclusion, the HRI method enables the assessment of blood vessel functionality and reactivity. Reference values from healthy subjects are presented and preliminary results demonstrate the potential of this method to complement perfusion imaging for the detection and follow up of angiogenesis in patients with brain tumors.

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“…Other studies have shown malignancies in the brain (meningiomas, gliomas or metastasis) can be distinguished from normal brain tissues using BOLD-MRI and in older patients with grade IV gliomas, BOLD signal intensity is equivalent to that measured in younger patients with grade IV gliomas, whereas in patients with grade II and III gliomas, BOLD-MRI signal change correlated only with increasing age [166,167].…”

Section: Imaging Hypoxia In Gliomasmentioning

confidence: 89%

Imaging hypoxia in gliomas

Mendichovszky¹,

Jackson²

2011

BJR

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The Blood Oxygen Level–Dependent Functional MR Imaging Signal Can Be Used to Identify Brain Tumors and Distinguish Them from Normal Tissue

Cited by 28 publications

References 34 publications

Brain Tumors: The Influence of Tumor Type and Routine MR Imaging Characteristics at BOLD Functional MR Imaging in the Primary Motor Gyrus

Brain Tumors: The Influence of Tumor Type and Routine MR Imaging Characteristics at BOLD Functional MR Imaging in the Primary Motor Gyrus

Hemodynamic Response Imaging: A Potential Tool for the Assessment of Angiogenesis in Brain Tumors

Imaging hypoxia in gliomas

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