The Blood-Retinal Barrier in Diabetes During Puberty

Abreu, J. R. Faria de; Silva, Rufino; Cunha-Vaz, Josè

doi:10.1001/archopht.1994.01090220084027

Cited by 12 publications

(9 citation statements)

References 10 publications

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“…A typical example is the functional changes in the retinal vasculature 13,14 resulting in a change of retinal tissue blood flow pattern including an increase in retinal blood flow and heterogeneity of distribution of retinal blood flow. 15 The retinal vasculature relies on local mechanisms to regulate appropriate blood flow.…”

Section: Retinal Blood Controlmentioning

confidence: 99%

The pathogenesis of diabetic retinopathy: old concepts and new questions

Cai

Boulton

2002

Eye

294

196

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Hyperglycaemia appears to be a critical factor in the aetiology of diabetic retinopathy and initiates downstream events including: basement membrane thickening, pericyte drop out and retinal capillary non-perfusion. More recently, focus has been directed to the molecular basis of the disease process in diabetic retinopathy. Of particular importance in the development and progression of diabetic retinopathy is the role of growth factors (eg vascular endothelial growth factor, placenta growth factor and pigment epithelium-derived factor) together with specific receptors and obligate components of the signal transduction pathway needed to support them. Despite these advances there are still a number of important questions that remain to be answered before we can confidently target pathological signals. How does hyperglycaemia regulate retinal vessels? Which growth factors are most important and at what stage of retinopathy do they operate? What is the preferred point in the growth factor signalling cascade for therapeutic intervention? Answers to these questions will provide the basis for new therapeutic interventions in a debilitating ocular condition.

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Section: Retinal Blood Controlmentioning

confidence: 99%

The pathogenesis of diabetic retinopathy: old concepts and new questions

Cai

Boulton

2002

Eye

294

196

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“…Convincing evidence has been presented by several groups (Cunha-Vaz et al 1979;Roy et al 1989;Abreu et al 1994) and by us (Nuzzi et al 1986(Nuzzi et al , 1988) that the diffusion of fluorescein into the vitreous, numerically expressed by the VPC, is modulated by the blood-ocular barrier. Less clear is the relationship of the VPC to the presence and severity of diabetic retinopathy.…”

Section: Discussionmentioning

confidence: 93%

“…Less clear is the relationship of the VPC to the presence and severity of diabetic retinopathy. While advanced forms of diabetic retinopathy are always associated with high VPC which roughly correlates with the severity of retinopathy (Prager et al 1983;Bursell et al 1984;Jackson et al 1990), it has been reported that diabetic patients with mild background retinopathy may have vitreous fluorometric readings in the normal range (Prager et al 1983) and that diabetics without ophthalmoscopic signs of retinopathy may show a breakdown of the BRB (Cunha- Vaz et al 1979;Nuzzi et al 1986;Abreu et al 1994). The relationship of VPC to the clinical parameters of the diabetic retinopathy has therefore not yet been convincingly established.…”

Section: Discussionmentioning

confidence: 99%

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Vitreous fluorophotometry and changes in blood‐retinal barrier permeability induced by Bendazac lysine

Nuzzi

Venturini

Gregorio

et al. 1997

Acta Ophthalmologica Scandinavica

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ABSTRACT. Vitreous fluorophotometry was used to investigate the effect of Bendazac lysine on the blood retinal barrier in 12 insulin-dependent diabetics with mild background retinopathy. The study was a randomized, double blind, cross-over trial, drug versus Placebo. Each treatment period was of 4 months. The vitreous penetration coefficient was reduced by 21% (95% c.i. 12, 30; p = 0.001) by treatment with respect to Placebo.Key words: insulin dependent diabetes -vitreous fluorophotometry -blood-retinal barrier -Bendazac lysine -Placebo -cross-over study.Acta Ophthalmol. Scand. 1997: 75: 41 -43 itreous fluorophotometry (VFPM)

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“…Elevated expression of matrix metalloproteinases may contribute to the increased vascular permeability in DR 230 . Vitreous fluorophotometry studies 231;232 demonstrate that in patients with DR, the blood-retinal barrier is stable until puberty, then progressively declines 233 . This early sign may also predict an unfavourable course over the long-term 234 .…”

Section: Blood-retinal Barrier Changesmentioning

confidence: 99%

A game changer for eye care for diabetes

Taylor

2017

Medical Journal of Australia

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The Blood-Retinal Barrier in Diabetes During Puberty

Cited by 12 publications

References 10 publications

The pathogenesis of diabetic retinopathy: old concepts and new questions

The pathogenesis of diabetic retinopathy: old concepts and new questions

Vitreous fluorophotometry and changes in blood‐retinal barrier permeability induced by Bendazac lysine

A game changer for eye care for diabetes

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