The blood serum concentration of cystatin C (γ-trace) as a measure of the glomerular filtration rate

Abstract

The blood serum concentrations of creatinine and the low molecular weight proteins cystatin C, beta 2-microglobulin and retinol-binding protein were measured in 106 patients whose glomerular filtration rates were assessed by Cr-ethylenediaminetetraacetate (EDTA)-clearance determinations. The reciprocals of the serum concentrations of creatinine, cystatin C and beta 2-microglobulin were closely correlated to the Cr-EDTA-clearance (r = 0.73, 0.75 and 0.70, respectively) in contrast to the corresponding values for retinol-binding protein (r = 0.39). The calculated values of the glomerular elimination rate for creatinine and cystatin C were normally distributed in contrast to those for beta 2-microglobulin. The calculated glomerular elimination rate of cystatin C was not correlated to age, sex, type of disorder or disease activity. The results demonstrate that the serum level of cystatin C is a better measure of the glomerular filtration rate than the serum level of beta 2-microglobulin.

Serum cystatin C as a marker of the renal function in patients with spinal cord injury

“…In agreement with previous studies dealing with patients having di erent kidney diseases 25 serum cystatin C and creatinine increased with decreasing GFR values. 23,25,26 Serum cystatin C correlated signi®cantly better to GFR than serum creatinine and estimated GFR. ROC plots allow simultaneous comparison of the diagnostic speci®city and sensitivity of serum cystatin C and creatinine.…”

“…Previous studies dealing with serum cystatin C as a parameter of GFR have suggested serum cystatin C to be as good a marker as serum creatinine 11,26,28 or even superior to serum creatinine. 8,10 Further studies demonstrated that in patients with normal to moderate impaired kidney function serum cystatin C seemed to be superior to creatinine as a parameter of GFR.…”

Serum levels of cystatin C in elderly lung cancer patients

“…In a recent review by Van Pottelbergh et al serum levels of Cys-C appear to be a promising method for estimating the glomerular filtration rate (GFR); however, estimating the GFR on the basis of serum Cys-C levels has not been extensively studied in the elderly (6). Earlier reports have indicated that the production rate of Cys-C is stable and does not change in inflammatory conditions (7,8). However, findings of recent reports have shown an association between serum Cys-C levels and inflammatory biomarkers such as C-reactive protein (CRP) (9,10).…”

Hyperfiltration Affects Accuracy of Creatinine eGFR Measurement

“…Serum CysC has been shown to be an excellent marker for GFR (6,12,13). It is a small-molecularweight protein (molecular weight ϭ 13 kD, positive charge with isoelectric point of 9.3) that was initially known as ␥-trace protein and its amino acid sequence was determined in 1981 (14,15).…”