In this paper, we report the peculiar HI morphology of the cluster spiral galaxy NGC 6145, which has a 150 kpc HI filament on one side that is nearly parallel to its major axis. This filament is made up of several HI clouds and the diffuse HI gas between them, with no optical counterparts. We compare its HI distribution with other one-sided HI distributions in the literature, and find that the overall HI distribution is very different from the typical tidal and ram-pressure stripped HI shape, and its morphology is inconsistent with being a pure accretion event. Only ∼30% of the total HI gas is anchored on the stellar disk, while most of HI gas forms the filament in the west. At a projected distance of 122 kpc, we find a massive elliptical companion (NGC 6146) with extended radio emission, whose axis points to an HI gap in NGC 6145. The velocity of the HI filament shows an overall light-ofsight motion of 80 to 180 km s −1 with respect to NGC 6145. Using the long-slit spectra of NGC 6145 along its major stellar axis, we find that some outer regions show enhanced star formation, while in contrast, almost no star formation activities are found in its center (<2 kpc). Pure accretion, tidal or ram-pressure stripping is not likely to produce the observed HI filament. An alternative explanation is the jet-stripping from NGC 6146, although direct evidence for a jet-cold gas interaction has not been found.