The BNP to Albumin Ratio and Heart Rate in Stroke Complicating Atrial Fibrillation

Lessomo, Fabrice Yves Ndjana; Luo, Xingfang; Fan, Qian; Afeku, Kevin; Wang, Zhiquan; Zhang, Zheng

doi:10.1016/j.cpcardiol.2022.101556

Cited by 1 publication

(1 citation statement)

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“…As coronary heart disease is the most common form of heart disease [ 30 ] and is of atherosclerotic origin, this may explain why we did not find any significant difference in BNP and NT-proBNP expression in AIS clots of LAA and CE etiology. In line with this, several recent studies associated high BNP/NT-pro BNP plasma levels with a higher risk of thrombotic events, although not only of cardioembolic etiology [ 31 , 32 , 33 , 34 ].…”

Section: Discussionmentioning

confidence: 58%

Investigating the Role of Brain Natriuretic Peptide (BNP) and N-Terminal-proBNP in Thrombosis and Acute Ischemic Stroke Etiology

Rossi,

Jabrah,

Douglas

et al. 2024

IJMS

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The need for biomarkers for acute ischemic stroke (AIS) to understand the mechanisms implicated in pathological clot formation is critical. The levels of the brain natriuretic peptides known as brain natriuretic peptide (BNP) and NT-proBNP have been shown to be increased in patients suffering from heart failure and other heart conditions. We measured their expression in AIS clots of cardioembolic (CE) and large artery atherosclerosis (LAA) etiology, evaluating their location inside the clots, aiming to uncover their possible role in thrombosis. We analyzed 80 thrombi from 80 AIS patients in the RESTORE registry of AIS clots, 40 of which were of CE and 40 of LAA etiology. The localization of BNP and NT-BNP, quantified using immunohistochemistry and immunofluorescence, in AIS-associated white blood cell subtypes was also investigated. We found a statistically significant positive correlation between BNP and NT-proBNP expression levels (Spearman’s rho = 0.668 p < 0.0001 *). We did not observe any statistically significant difference between LAA and CE clots in BNP expression (0.66 [0.13–3.54]% vs. 0.53 [0.14–3.07]%, p = 0.923) or in NT-proBNP expression (0.29 [0.11–0.58]% vs. 0.18 [0.05–0.51]%, p = 0.119), although there was a trend of higher NT-proBNP expression in the LAA clots. It was noticeable that BNP was distributed throughout the thrombus and especially within platelet-rich regions. However, NT-proBNP colocalized with neutrophils, macrophages, and T-lymphocytes, suggesting its association with the thrombo-inflammatory process.

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