The body temperature response of two inbred strains of mice to handling, saline and amphetamine

Brown, Annie M.; Julian, Thelma

doi:10.1016/0028-3908(68)90065-8

Cited by 18 publications

(7 citation statements)

References 7 publications

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“…A sex difference in body temperature changes that occur in response to handling and in regard to amphetamine toxicity in C3H mice was also reported by Brown & Julian (1968). It should be noted that a hypothermic effect was also observed by other authors in Swiss mice (McCullough, Milberg & Robinson, 1970) and in rats (Jellinek, 1971) after intraperitoneal doses of amphetamine (1 mg/kg) or after an intracerebral injection of few micrograms of this compound.…”

Section: Discussionsupporting

confidence: 61%

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Interaction of (+)‐amphetamine with cerebral dopaminergic neurones in two strains of mice, that show different temperature responses to this drug

Caccia

Cecchetti

Garattini

et al. 1973

British J Pharmacology

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Summary1. (+ )-Amphetamine sulphate elicits a dose-dependent hyperthermia in NMRI mice but it does not significantly increase the body temperature of CsH mice.2. When low doses of (+)-amphetamine are given, the body temperature of C3H mice decreases. 3. (+)-Amphetamine decreases the noradrenaline concentration in the brainstem and increases the homovanillic acid concentration (HVA) in the striatum of NMRI mice, but only slightly reduces the noradrenaline concentration and does not change the HVA concentration in the brains of C3H mice. 4. The two strains appear to show a difference in the metabolism of dopamine in the striatum. The rates at which dopamine disappears from the tissue after blocking catecholamine synthesis with a-methyltyrosine and the rates at which HVA accumulates after blocking the active transport of this metabolite out of the brain with probenecid suggest that the turnover of dopamine is lower in C3H mice than in NMRI mice.

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Section: Discussionsupporting

confidence: 61%

“…Chai (1958) has shown that thyroid activity may be different in various strains of mice. A relative lack of thyroid function may explain the lack of hyperthermic activity of amphetamine in C3H mice (Dolfini, et al, 1970;Brown & Julian, 1968).…”

Section: Discussionmentioning

confidence: 99%

Interaction of (+)‐amphetamine with cerebral dopaminergic neurones in two strains of mice, that show different temperature responses to this drug

Caccia

Cecchetti

Garattini

et al. 1973

British J Pharmacology

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“…It is appropriate to mention here that there are other commonly overlooked factors that can significantly affect the animal's thermo-regulatory system. For example Brown & Julian (1968) found that, 20 min after first handling, the Tb of C3H mice was raised by more than I "C for 1-2 hours. Georgiev (1978), using telemetric methods, showed that weighing and taking the rectal temperature (&) of a rat caused an increase of 0.7 "C in the Tb for about I h (see Fig.…”

Section: Temperaturementioning

confidence: 99%

Environmental Effects on Animals Used in Biomedical Research

Clough

1982

Biological Reviews

154

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Summary I. Reliability of the results of bio‐medical research clearly depends upon the animals used showing as standard responses as is possible. 2. The majority of animals used in this field are small, homoiothermic mammals which have sensitive and strong homeostatic mechanisms. If a change in ambient conditions is of sufficient magnitude to unbalance homeostasis, then the neuroendocrine system is stimulated so as to restore it, and this can interfere with the response to test conditions or agents. 3. The homeostatic effectors involved are diverse and can include both physiological and behavioural changes in the animal. These can affect metabolic rate, body temperature, activity, food consumption, hormone concentration, wake/sleep patterns, maturation, posture, lactation and many other bodily functions. Any of these changes is potentially capable of influencing experimental results. 4. The evidence presented shows how environmental factors may affect the outcome of experiments in the fields of animal behaviour, cancer research, immunology, pathology, pharmacology, psychology, reproduction, teratology and toxicology; particular attention is paid to the effects of ambient temperature, relative humidity, air movement and quality, light and sound. 5. While a constant, reproducible environment would be ideal, there is little possibility of controlling all the variables; nevertheless all investigators should minimize those environmental variables that have been shown to be important. 6. To enable other investigators to repeat experiments or carry out comparative studies, environmental conditions pertaining during an experiment should be adequately described in any publications.

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“…Many reports of differenees in temperature response to amphetamine in miee of different strains are available (BROWN and JULIAN, 1968;DOLFINI et al, 1969a;SCOTT et al, 1971;CRAIGMILL et al, 1973). Many reports of differenees in temperature response to amphetamine in miee of different strains are available (BROWN and JULIAN, 1968;DOLFINI et al, 1969a;SCOTT et al, 1971;CRAIGMILL et al, 1973).…”

Section: D) Other Factors Influencing Amphetamine-induced Hyperthermiamentioning

confidence: 99%

General Pharmacology of Amphetamine-Like Drugs

Änggård¹,

Lewander²,

Gunne³

1973

Drug Addiction II

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Amphetamine and related central stimulant drugs are derivatives of ß-phenylethylamine (Table 1) and are thus relatively simple organic bases. The general ßphenylethylamine skeleton is one which amphetamine shares with the neurotransmitters noradrenaline, adrenaline, and dopamine. Phenylethylamine itselfhas central stimulant properties, but has an extremely short half-life in the body due to rapid metabolism by monoamine oxidase (MAO). Amphetamine has, due to steric hindrance by the ex-methyl group, much less affinity for MAO and therefore has a longer half-Iife.Most amphetamines have cardiovascular, psychomotor stimulant, hyperthermic, and anorexigenic actions. All of the structural features of amphetamine are important far its spectrum of pharmacologic activity. Any alteration may enhance, diminish, or attenuate one or several components in the actions of the parent drug. (1) Substitution of the phenyl ring, (2) alteration of the length of the side chain, (3) substitution on the primary nitrogen group, (4) substitution of the ex-and ß-carbon atoms, and (5) their absolute configuration have been studied and will be briefly discussed here. For a more thorough review on the subject the reader is referred to the papers by BIEL (1970), vANRossuM and SIMONS (1969) and VREE (1973. The effect of ring and side-chain substitution on distribution and elimination of the amphetamines has been discussed by BECKETT and BROOKES (1970). recently reviewed the biochemical pharmacology of the amphetamines. The metabolism and disposition of methylphenidate were reported by F ARAJ et al.

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The body temperature response of two inbred strains of mice to handling, saline and amphetamine

Cited by 18 publications

References 7 publications

Interaction of (+)‐amphetamine with cerebral dopaminergic neurones in two strains of mice, that show different temperature responses to this drug

Interaction of (+)‐amphetamine with cerebral dopaminergic neurones in two strains of mice, that show different temperature responses to this drug

Environmental Effects on Animals Used in Biomedical Research

General Pharmacology of Amphetamine-Like Drugs

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