Global warming is harmful to the environment and CO2 is one of the major greenhouse gases. CCS-EOR technology can increase oil production and sequester CO2. During the storage and transportation of high-pressure CO2, BLEVE may occur. In this study, the dynamic pressure parameters in the supercritical CO2 BLEVE process were numerically simulated by using numerical simulation, and the effects of initial temperature and initial charge on the dynamic pressure parameters in the supercritical CO2 BLEVE process were mainly discussed. By thoroughly investigating the dynamic pressure of BLEVE of supercritical CO2, we can better understand and predict the conditions under which such accidents occur, and further improve the safety of industrial processes.