The BOLD cerebrovascular reactivity response to progressive hypercapnia in young and elderly

Bhogal, Alex A.; Vis, Jill B. De; Siero, Jeroen C.W.; Petersen, Esben Thade; Luijten, Peter R.; Hendrikse, Jeroen; Philippens, M.E.P.; Hoogduin, Hans

doi:10.1016/j.neuroimage.2016.06.010

Cited by 41 publications

(43 citation statements)

References 61 publications

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“…In the present study, both methods showed impaired GM CVR with advanced age, and BOLD-MRI showed a slower hemodynamic response to CO 2 . These results are consistent with previous reports in the literature and have been associated with age-related arteriosclerosis and vascular stiffening (1,10,36,37). …”

Section: Discussionsupporting

confidence: 93%

Cerebral blood flow and vasoreactivity in aging: an arterial spin labeling study

Leoni

Oliveira

Pontes-Neto

et al. 2017

Braz J Med Biol Res

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Regional cerebral blood flow (CBF) and cerebrovascular reactivity (CVR) in young and elderly participants were assessed using pulsed arterial spin labeling (ASL) and blood oxygenation level-dependent (BOLD) magnetic resonance imaging (MRI) techniques in combination with inhalation of CO2. Pulsed ASL and BOLD-MRI were acquired in seventeen asymptomatic volunteers (10 young adults, age: 30±7 years; 7 elderly adults, age: 64±8 years) with no history of diabetes, hypertension, and neurological diseases. Data from one elderly participant was excluded due to the incorrigible head motion. Average baseline CBF in gray matter was significantly reduced in elderly (46±9 mL·100 g-1·min-1) compared to young adults (57±8 mL·100 g-1·min-1; P=0.02). Decreased pulsed ASL-CVR and BOLD-CVR in gray matter were also observed in elderly (2.12±1.30 and 0.13±0.06 %/mmHg, respectively) compared to young adults (3.28±1.43 and 0.28±0.11 %/mmHg, respectively; P<0.05), suggesting some degree of vascular impairment with aging. Moreover, age-related decrease in baseline CBF was observed in different brain regions (inferior, middle and superior frontal gyri; precentral and postcentral gyri; superior temporal gyrus; cingulate gyri; insula, putamen, caudate, and supramarginal gyrus). In conclusion, CBF and CVR were successfully investigated using a protocol that causes minimal or no discomfort for the participants. Age-related decreases in baseline CBF and CVR were observed in the cerebral cortex, which may be related to the vulnerability for neurological disorders in aging.

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Section: Discussionsupporting

confidence: 93%

Cerebral blood flow and vasoreactivity in aging: an arterial spin labeling study

Leoni

Oliveira

Pontes-Neto

et al. 2017

Braz J Med Biol Res

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“…To date, most studies using a ramp protocol with SGD have been conducted specifically to test different physiological CVR relationships (i.e., linear, sigmoidal, etc.) (Bhogal et al, ) in order to better describe CVR (Bhogal et al, ; Sobczyk et al, ) or, simply, the utility in diagnosing steno‐occlusive diseases (De Vis et al, , ; Duffin et al, ). To our knowledge, no studies have specifically investigated, nor reported, the reproducibility of a ramp sequence to assess changes in CVR.…”

Section: Introductionmentioning

confidence: 99%

Reproducibility of a ramping protocol to measure cerebral vascular reactivity using functional magnetic resonance imaging

Evanoff

Mueller

Marlatt

et al. 2020

Clin Physio Funct Imaging

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Though individual differences in arterial carbon dioxide and oxygen levels inherently exist, the degree of their influence on cerebral vascular reactivity (CVR) is less clear. We examined the reproducibility of BOLD signal changes to an iso‐oxic ramping PetCO2 protocol. CVR changes were induced by altering PetCO2 while holding PetO2 constant using a computer‐controlled sequential gas delivery (SGD) device. Two MRI scans, each including a linear change in PetCO2, were performed using a 3‐Tesla (3T) scanner. This ramp sequence consisted of 1 min at 30 mmHg followed by 4 min period during where PetCO2 was linearly increased from 30 to 50 mmHg, 1 min at 51 mmHg, and concluded with 4 min at baseline. The protocol was repeated at a separate visit with 3 days between visits (minimum). Intraclass correlation coefficients (ICC) and coefficients of variation (CV) were used to verify reproducibility. Eleven subjects (6 females; mean age 26.5 ± 5.7 years) completed the full testing protocol. Good reproducibility was observed for the within‐visit ramp sequence (Visit 1: ICC = 0.82, CV = 6.5%; Visit 2: ICC = 0.74, CV = 6.4%). Similarly, ramp sequence were reproducible between visits (Scan 1: ICC = 0.74, CV = 6.5%; Scan 2: ICC = 0.66, CV = 6.1%). Establishing reproducible methodologies for measuring BOLD signal changes in response to PetCO2 alterations using a ramp protocol will allow researchers to study CVR functionality. Finally, adding a ramping protocol to CVR studies could provide information about changes in CVR over a broad range of PetCO2.

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“…To the best of our knowledge our team is the first to show that the acetazolamide effect persists for at least 60 minutes in subjects with chronic carotid artery stenosis (Szarmach et al, 2017a). There is accumulating evidence that CVR should be seen as a process of temporally and spatially defined dynamics rather than a single value based on measurement at the point of the highest response (Bhogal et al, 2014;Bhogal et al, 2015;Bhogal et al, 2016). It has been demonstrated that various white (WM) and grey matter (GM) structures in healthy subjects show substantial differences in CVR to increasing concentrations of breathing carbon dioxide (CO 2 , Bhogal et al, 2014).…”

Section: Delayed Acetazolamide Testmentioning

confidence: 98%

Regional resting state perfusion variability and delayed cerebrovascular uniform reactivity in subjects with chronic carotid artery stenosis

et al. 2018

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The aim of this study was to assess regional perfusion at baseline and regional cerebrovascular resistance (CVR) to delayed acetazolamide challenge in subjects with chronic carotid artery stenosis.Sixteen patients (ten males) aged 70.94±7.71 with carotid artery stenosis ≥90% on the ipsilateral side and ≤50% on the contralateral side were enrolled into the study. In all patients, two computed tomography perfusion examinations were carried out; the first was performed before acetazolamide administration and the second 60 minutes after injection.The differences between mean values were examined by paired two-sample t-test and alternative nonparametric Wilcoxon’s test. Normality assumption was examined using W Shapiro-Wilk test.The lowest resting-state cerebral blood flow (CBF) was observed in white matter (ipsilateral side: 18.4±6.2; contralateral side: 19.3±6.6) and brainstem (ipsilateral side: 27.8±8.5; contralateral side: 29.1±10.8). Grey matter (cerebral cortex) resting state CBF was below the normal value for subjects of this age: frontal lobe – ipsilateral side: 30.4±7.0, contralateral side: 33.7±7.1; parietal lobe – ipsilateral side: 36.4±11.3, contralateral side: 42.7±9.9; temporal lobe – ipsilateral side: 32.5±8.6, contralateral side: 39.4±10.8; occipital lobe – ipsilateral side: 24.0±6.0, contralateral side: 26.4±6.6). The highest resting state CBF was observed in the insula (ipsilateral side: 49.2±17.4; contralateral side: 55.3±18.4). A relatively high resting state CBF was also recorded in the thalamus (ipsilateral side: 39.7±16.9; contralateral side: 41.7±14.1) and cerebellum (ipsilateral side: 41.4±12.2; contralateral side: 38.1±11.3). The highest CVR was observed in temporal lobe cortex (ipsilateral side: +27.1%; contralateral side: +26.1%) and cerebellum (ipsilateral side: +27.0%; contralateral side: +34.6%). The lowest CVR was recorded in brain stem (ipsilateral side: +20.2%; contralateral side: +22.2%) and white matter (ipsilateral side: +18.1%; contralateral side: +18.3%). All CBF values were provided in milliliters of blood per minute per 100 g of brain tissue [ml/100g/min]. Resting state circulation in subjects with carotid artery stenosis is low in all analysed structures with the exception of insula and cerebellum. Acetazolamide challenge yields relatively uniform response in both hemispheres in the investigated population.Grey matter is more reactive to acetazolamide challenge than white matter or brainstem.

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The BOLD cerebrovascular reactivity response to progressive hypercapnia in young and elderly

Cited by 41 publications

References 61 publications

Cerebral blood flow and vasoreactivity in aging: an arterial spin labeling study

Cerebral blood flow and vasoreactivity in aging: an arterial spin labeling study

Reproducibility of a ramping protocol to measure cerebral vascular reactivity using functional magnetic resonance imaging

Regional resting state perfusion variability and delayed cerebrovascular uniform reactivity in subjects with chronic carotid artery stenosis

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