The bone-promoting actions of formononetin in established osteopenia

Pru, James K.

doi:10.1097/gme.0b013e31825e9be3

Cited by 5 publications

(4 citation statements)

References 21 publications

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“…Unlike soy, RC has a high content of both formononetin and biochanin A, and studies in ovariectomised rat models have shown that formononetin contributes to bone formation process by stimulation differentiation of osteoblasts [ 14 , 15 , 25 ]. In addition formononetin has a higher estrogenic activity than daidzein [ 26 ]. Biochanin A has been demonstrated to induce a reduction in resorption of bone at the femoral neck when given to ovariectomised rats [ 27 ].…”

Section: Introductionmentioning

confidence: 99%

Intake of Novel Red Clover Supplementation for 12 Weeks Improves Bone Status in Healthy Menopausal Women

Thorup

Lambert

Kahr

et al. 2015

Evidence-Based Complementary and Alternative Medicine

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Objective. To investigate the effect by which daily consumption of a novel red clover (RC) extract influences bone health, inflammatory status, and cardiovascular health in healthy menopausal women. Design. A 12-week randomized, double-blinded, placebo-controlled trial involving 60 menopausal women receiving a daily dose of 150 mL RC extract containing 37.1 mg isoflavones (33.8 mg as aglycones) or placebo. Methods. Bone parameters were changes in bone mineral density (BMD), bone mineral content (BMC), and T-score at the lumbar spine and femoral neck. Bone turnover (CTx) and inflammatory markers were measured in plasma and finally blood pressure (BP) was evaluated. Results. RC extract had positive effect on bone health, and only the women receiving the placebo experienced a decline in BMD (p < 0.01) at the lumbar spine. T-score at the lumbar spine only decreased in the placebo group (p < 0.01). CTx decreased in the RC group with −9.94 (±4.93)%, although not significant. Conclusion. Daily consumption of RC extract over a 12-week period was found to have a beneficial effect on bone health in menopausal women based on BMD and T-score at the lumbar spine and plasma CTx levels. No changes in BP or inflammation markers were found and no side effects were observed.

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Section: Introductionmentioning

confidence: 99%

Intake of Novel Red Clover Supplementation for 12 Weeks Improves Bone Status in Healthy Menopausal Women

Thorup

Lambert

Kahr

et al. 2015

Evidence-Based Complementary and Alternative Medicine

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“…These observations coincide with the results obtained in our study (data not shown). Some authors suggest that the examination of bone biomechanical features is essential for confirming beneficial effect of formononetin demonstrated in previous studies [37, 38]. It is widely known that, apart from bone microarchitecture, the chemical composition of bones has an influence on its mechanical properties.…”

Section: Discussionmentioning

confidence: 91%

“…Formononetin is suggested to be a natural selective estrogen receptor modulator (SERM) [37, 38]. SERMs, such as raloxifene, reveal estrogenic activity in bone cells, thus they inhibit osteoporosis development in postmenopausal women, without uterotropic and mammotropic effects [39–41].…”

Section: Discussionmentioning

confidence: 99%

Effect of Formononetin on Mechanical Properties and Chemical Composition of Bones in Rats with Ovariectomy-Induced Osteoporosis

Kaczmarczyk-Sedlak

Wojnar

Zych

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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Formononetin is a naturally occurring isoflavone, which can be found in low concentrations in many dietary products, but the greatest sources of this substance are Astragalus membranaceus, Trifolium pratense, Glycyrrhiza glabra, and Pueraria lobata, which all belong to Fabaceae family. Due to its structural similarity to 17β-estradiol, it can mimic estradiol's effect and therefore is considered as a “phytoestrogen.” The aim of this study was to examine the effect of formononetin on mechanical properties and chemical composition of bones in rats with ovariectomy-induced osteoporosis. 12-week-old female rats were divided into 4 groups: sham-operated, ovariectomized, ovariectomized treated with estradiol (0.2 mg/kg) and ovariectomized treated with formononetin (10 mg/kg). Analyzed substances were administered orally for 4 weeks. Ovariectomy caused osteoporotic changes, which can be observed in bone biomechanical features (decrease of maximum load and fracture load and increase of displacements for maximum and fracture loads) and bone chemical composition (increase of water and organic fraction content, while a decrease of minerals takes place). Supplementation with formononetin resulted in slightly enhanced bone mechanical properties and bone chemistry improvement (significantly lower water content and insignificantly higher mineral fraction content). To summarize, administration of formononetin to ovariectomized rats shows beneficial effect on bone biomechanical features and chemistry; thus, it can prevent osteoporosis development.

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“…This isoflavinoid also has beneficial effect on osteoarthritis (140). The constituents of formononetin are natural SERM (141,142). SERMs like raloxifene, revealed estrogenic activity in the bone cells and help in the treatment of osteoporosis in postmenopausal women without mammotropic and uterotrophic effects (143).…”

Section: Glycyrrhiza Glabra (Family: Fabaceae)mentioning

confidence: 99%