The bone scan in inflammatory osseous disease

Handmaker, Hirsch; Leonards, Richard

doi:10.1016/s0001-2998(76)80039-6

Cited by 130 publications

(16 citation statements)

References 6 publications

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“…Threephase bone scanning with 99m Tc methylene diphosphonate and its analogues has long been utilized to evaluate patients with suspected osteomyelitis (36,112,130) with a relatively high sensitivity and is currently considered to be the nuclear medicine imaging test of choice for the early diagnosis of osteomyelitis. Bone scintigraphy can effectively detect osteomyelitis within 24 h after the onset of symptoms (60). However, the specificity of the three-phase bone scintigraphy is not high, particularly in patients with prior traumatic injury to the osseous structures, with metal prostheses, or with neuropathic joints.…”

Section: Skeletal Infectionmentioning

confidence: 99%

Role of Modern Imaging Techniques for Diagnosis of Infection in the Era of¹⁸F-Fluorodeoxyglucose Positron Emission Tomography

et al. 2008

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During the past several years, it has become quite evident that positron emission tomography (PET) with 18F-fluorodeoxyglucose (FDG) imaging can play a major role in the management of patients with suspected infection. Particularly, several groups have demonstrated that this powerful imaging methodology is very effective in the evaluation of osteomyelitis, infected prostheses, fever of unknown origin, and AIDS. In view of its extraordinary sensitivity in detecting disease activity and the ability to quantitate the degree of FDG uptake, PET might prove to be an appropriate modality for monitoring disease activity and evaluating response to therapy. FDG-PET has many advantages over existing imaging techniques for the diagnosis of infectious diseases. These include feasibility of securing diagnostic results within 1.5 to 2 h, excellent spatial resolution, and accurate anatomical localization of sites of abnormality. The availability of PET/computed tomography as a practical tool has further enhanced the role of metabolic imaging in many settings. In the future, this modality is very likely to be employed on a routine basis for detecting, characterizing, and monitoring patients with suspected and proven infection.

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Section: Skeletal Infectionmentioning

confidence: 99%

Role of Modern Imaging Techniques for Diagnosis of Infection in the Era of¹⁸F-Fluorodeoxyglucose Positron Emission Tomography

et al. 2008

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“…This technique was considered as the imaging modality of choice for diagnosing osteomyelitis, becoming positive within 24-48 h of the onset of symptoms [17] . Bone scan is very sensitive but not specifi c for detection of infection in diabetic patients as it is also positive in diabetic neuroarthropathy [16] .…”

Section: Discussionmentioning

confidence: 99%

Evaluating Diabetic Foot Infection with Magnetic Resonance Imaging: Kuwait Experience

et al. 2005

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Objective: The aim of this study was to evaluate the capability of magnetic resonance imaging (MRI) to depict and characterize the changes seen in diabetic foot infections. Subjects and Methods: MRI studies of 29 diabetic patients with suspected foot infection were evaluated. Sagittal and transverse T₁-weighted images before and after intravenous gadolinium, and transverse fat-suppressed T₂-weighted images were performed on the affected regions. The MRI findings were compared to subsequent clinical and/or histopathological findings. Results: The MRI findings were: osteomyelitis in 14 patients, abscess in 5, cellulitis in 26, tenosynovitis in 4 and neuropathic joint in 8. Three cases were normal. Pathological confirmations were obtained in 19 patients. MRI and histological diagnosis were in concordance in 79% of osteomyelitis cases, 100% of neuropathy cases and 100% of cellulitis cases. The sensitivity and specificity of MRI in diagnosing osteomyelitis were 100 and 63%, respectively. The positive predictive and negative predictive values, and the accuracy were 79, 100 and 84%, respectively. MRI helped surgical planning for limb salvage procedures in 6 of the osteomyelitis cases and in a cellulitis case. Conclusion: The results indicate that MRI is a sensitive and accurate imaging modality for the evaluation of foot infections in diabetic patients and for planning proper treatment.

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“…4 was, 56 m,m/hr'., On the fifth hospital day, radio-' ~ graphs, of ~,the lower extremities showed~ no ' skeletal .' and again between 2-3 hours after in-.'…”

Section: ''mentioning

confidence: 95%

Pitfalls in the Diagnosis of Acute Osteomyelitis by Bone Scan

Wald

Mirro

Gartner

1980

Clin Pediatr (Phila)

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Two patients with acute osteomyelitis had technetium 99m methylene diphosphonate bone images that were misinterpreted. A review of six prospective evaluations of technetium scanning in the diagnosis of acute osteomyelitis shows that bone image interpretation may be misleading in five to seven per cent of pediatric patients. Definitive diagnostic procedures and management should not be delayed until a positive bone scan is obtained, if the clinical findings are persuasive.

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The bone scan in inflammatory osseous disease

Cited by 130 publications

References 6 publications

Role of Modern Imaging Techniques for Diagnosis of Infection in the Era of¹⁸F-Fluorodeoxyglucose Positron Emission Tomography

Role of Modern Imaging Techniques for Diagnosis of Infection in the Era of¹⁸F-Fluorodeoxyglucose Positron Emission Tomography

Evaluating Diabetic Foot Infection with Magnetic Resonance Imaging: Kuwait Experience

Pitfalls in the Diagnosis of Acute Osteomyelitis by Bone Scan

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The bone scan in inflammatory osseous disease

Cited by 130 publications

References 6 publications

Role of Modern Imaging Techniques for Diagnosis of Infection in the Era of18F-Fluorodeoxyglucose Positron Emission Tomography

Role of Modern Imaging Techniques for Diagnosis of Infection in the Era of18F-Fluorodeoxyglucose Positron Emission Tomography

Evaluating Diabetic Foot Infection with Magnetic Resonance Imaging: Kuwait Experience

Pitfalls in the Diagnosis of Acute Osteomyelitis by Bone Scan

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Role of Modern Imaging Techniques for Diagnosis of Infection in the Era of¹⁸F-Fluorodeoxyglucose Positron Emission Tomography

Role of Modern Imaging Techniques for Diagnosis of Infection in the Era of¹⁸F-Fluorodeoxyglucose Positron Emission Tomography