“…The roles of testosterone and oxytocin in other psychiatric disorders involving dysregulated social cognition, especially the major psychoticâaffective disorders schizophrenia, bipolar disorder, and depression that share symptoms and risk factors, have been less well investigated than for autism, both theoretically and empirically; indeed, conceptual, hypotheticâdeductive frameworks have yet to be developed in this context, despite the obvious importance of social hormones in human psychological phenotypes. A recently developed model for understanding the psychoticâaffective disorders, in comparison to autism, is that they involve forms of dysfunctional, âhyperâdevelopedâ social cognition, as demonstrated, for example, in such phenotypes as paranoia, other social delusions, auditory hallucination, megalomania, high levels of social emotion including guilt, shame, pride, or embarrassment, high empathic drive, and high social motivation as observed in mania (Crespi & Badcock, ; Backasch et al, ; Dinsdale & Crespi, ; Dinsdale et al, ; Sharp et al, ; Crespi & Leach, ). This model is based on the simple presumptions that evolution along the human lineage has predominantly involved increases in social cognition and emotionality (the wellâsupported âsocial brainâ hypothesis) (Dunbar & Shultz, ), and that all biological phenotypes can be perturbed in two opposite directions, towards either lower or higher expression of some trait, pathway, or system, both of which cause performance deficits although by different means.…”