The brain development of infants with intrauterine growth restriction: role of glucocorticoids

Ding, Ying‐Xue; Cui, Hong

doi:10.1515/hmbci-2019-0016

Cited by 6 publications

(3 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several explanations are possible. First, while gestational is considered as the primary independent variable for organ maturation of newborn infants, other variables, such as maternal, nutritional, and genetic factors, are also crucial [ 32 , 33 ]. These variables might also influence citrulline metabolism.…”

Section: Discussionmentioning

confidence: 99%

Antenatal Growth, Gestational Age, Birth, Enteral Feeding, and Blood Citrulline Levels in Very Low Birth Weight Infants

Obayashi,

Iwata,

Okuda

et al. 2024

Nutrients

View full text Add to dashboard Cite

Early enteral nutrition using reliable biomarkers of intestinal function must be established to improve neurodevelopmental outcomes in very low birth weight infants (VLBWIs). Serum citrulline levels reflect the intestinal function in adults. To elucidate the relationship among antenatal growth, postnatal enteral nutrition, and blood citrulline levels, a retrospective single-center observational study was conducted on 248 VLBWIs born between April 2014 and March 2021. A mixed effect model and post hoc simple slope analysis were used to estimate the correlations between clinical variables and citrulline levels at Early (day 5.1) and Late (day 24.3) postnatal ages. Greater gestational age, birth weight, and amount of enteral nutrition at the time of blood sampling were associated with lower citrulline levels at the Early postnatal age and higher citrulline levels at the Late postnatal age. Provided that Early citrulline levels predominantly reflect the consequence of antenatal citrulline metabolism, it is suggested that fetal growth and maturation are likely to promote citrulline catabolism in utero and its synthesis after birth. With additional insights into the temporal transition point wherein the maturation-dependent balance of citrulline metabolism shifts from catabolism-dominant to synthesis-dominant, citrulline emerges as a potential biomarker for assessing intestinal function and gastrointestinal disorders.

show abstract

Section: Discussionmentioning

confidence: 99%

Antenatal Growth, Gestational Age, Birth, Enteral Feeding, and Blood Citrulline Levels in Very Low Birth Weight Infants

Obayashi,

Iwata,

Okuda

et al. 2024

Nutrients

View full text Add to dashboard Cite

show abstract

“…Low birth weight and prenatal malnutrition are associated with neurodevelopmental disorders [19,20]; however, the exact mechanism is yet to be clarified. A previous study speculated that the adverse intrauterine environment leads to the hypothalamus-pituitaryadrenal axis resetting, and long-term stimulation of glucocorticoids damages the microvascular endothelial cells, resulting in nerve injury in infants with IUGR [21]. The scarcity of uterine resources restricts intrauterine growth, which has a detrimental effect on cognitive development in childhood.…”

Section: Discussionmentioning

confidence: 99%

Physical growth and intelligence development of discordant dizygotic twins from birth to preschool age: a prospective cohort study

et al. 2022

View full text Add to dashboard Cite

Background The majority of studies are limited to adverse perinatal outcomes and poor cognitive abilities in the short term in discordant monochorionic twins. Methods To determine whether small and large discordant dizygotic twins differ in physical growth and intelligence development and weight and height from birth up to 6 years of age were measured in 34 dizygotic twin pairs with ≥ 20% birth weight discordance. Mental developmental index (MDI) and psychomotor developmental index (PDI) were calculated at 1 year, while the Wechsler Intelligence Scale for Children-IV (WISC-IV) full-scale intelligence quotient (IQ) was assessed at the age of 6. Results The difference in height and weight in each stage differed significantly from birth to 72-months-old (P < 0.05), although there was disappointing catch-up growth in smaller twins. PDI but not MDI at 1 year of age was significantly different between the two groups (P < 0.05), and smaller twins experienced higher psychomotor retardation rates (P < 0.05). Also, the influence of height and weight on PDI was statistically significant (P < 0.05). No significant difference was detected in the WISC-IV full-scale IQ at the age of 6; however, the full-scale IQ may be affected by the history of suffocation and the S/D value (P = 0.011, P = 0.022). Conclusions Intrauterine fetal growth and development lead to birth weight differences in twins and sustain an impact on the children’s physical growth in height and weight from birth to preschool age, causing psychomotor developmental differences at 1 year of age. However, the differences in psychomotor development decrease gradually by the age of 6.

show abstract

“…The pituitary gland plays a significant role in the endocrine system by secreting hormones that regulate normal physiological functions of the body. Transcriptome profiling studies have implicated intrauterine adverse environments and the disruption of the hypothalamus–pituitary–adrenal (HPA) axis in the development of IUGR [ 14 ]. However, the underlying mechanisms associated with pituitary disfunction in IUGR piglet remain poorly understood.…”

Section: Introductionmentioning

confidence: 99%

Pituitary-Gland-Based Genes Participates in Intrauterine Growth Restriction in Piglets

Shen²,

Wu³

et al. 2022

Genes

View full text Add to dashboard Cite

Intrauterine growth restriction (IUGR) is a major problem associated with piglet growth performance. The incidence of IUGR is widespread in Rongchang pigs. The pituitary gland is important for regulating growth and metabolism, and research has identified genes associated with growth and development. The pituitary gland of newborn piglets with normal birth weight (NBW group, n = 3) and (IUGR group, n = 3) was collected for transcriptome analysis. A total of 323 differentially expression genes (DEGs) were identified (|log2(fold-change)| > 1 and q value < 0.05), of which 223 were upregulated and 100 were downregulated. Gene Ontology (GO) functional and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses showed that the DEGs were mainly related to the extracellular matrix, regulation of the multicellular organismal process, tissue development and angiogenesis, which participate in the growth and immune response in IUGR piglets. Moreover, 7 DEGs including IGF2, THBS1, ITGA1, ITGA8, EPSTI1, FOSB, and UCP2 were associated with growth and immune response. Furthermore, based on the interaction network analysis of the DEGs, two genes, IGF2 and THBS1, participated in cell proliferation, embryonic development and angiogenesis. IGF2 and THBS1 were also the main genes participating in the IUGR. This study identified the core genes involved in IUGR in piglets and provided a reference for exploring the effect of the pituitary gland on piglet growth.

show abstract

The brain development of infants with intrauterine growth restriction: role of glucocorticoids

Cited by 6 publications

References 39 publications

Antenatal Growth, Gestational Age, Birth, Enteral Feeding, and Blood Citrulline Levels in Very Low Birth Weight Infants

Antenatal Growth, Gestational Age, Birth, Enteral Feeding, and Blood Citrulline Levels in Very Low Birth Weight Infants

Physical growth and intelligence development of discordant dizygotic twins from birth to preschool age: a prospective cohort study

Pituitary-Gland-Based Genes Participates in Intrauterine Growth Restriction in Piglets

Contact Info

Product

Resources

About