2000
DOI: 10.1016/s0014-2999(00)00677-4
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The brain mineralocorticoid receptor: greedy for ligand, mysterious in function

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Cited by 201 publications
(144 citation statements)
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“…The results of previous studies have shown that DEX induces apoptosis by activating GR: 36 although some earlier reports have suggested that DEX may bind to MR under specific in vitro conditions, there is strong evidence that DEX is predominantly a GR agonist. 45 The apoptotic actions of DEX (10 À5 M) were shown to be significantly attenuated when the MR agonist ALDO (10 À5 M) was added to the culture medium. This finding is consistent with previous results obtained in rats.…”
Section: Discussionmentioning
confidence: 99%
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“…The results of previous studies have shown that DEX induces apoptosis by activating GR: 36 although some earlier reports have suggested that DEX may bind to MR under specific in vitro conditions, there is strong evidence that DEX is predominantly a GR agonist. 45 The apoptotic actions of DEX (10 À5 M) were shown to be significantly attenuated when the MR agonist ALDO (10 À5 M) was added to the culture medium. This finding is consistent with previous results obtained in rats.…”
Section: Discussionmentioning
confidence: 99%
“…To detect GR and MR mRNA transcripts in the cultures, total RNA, free from chromosomal DNA contamination, was isolated (RNAeasy kit, Qiagen, Hilden, Germany) and reverse transcribed with SUPERSCRIPTt II RNA H-reverse transcriptase (Life Technologies) using custom-synthesized oligo-dT [12][13][14][15][16][17][18] primers (MWG Biotech, Ebersberg, Germany). Published primers 24 were used and amplification conditions were denaturation for 40 s at 941C, annealing for 1 min at 621C (MR) or 401C (GR), and primer extension for 2 min at 721C; optimal amplifications of MR and GR mRNA were achieved after 35 and 25 cycles, respectively.…”
Section: Reverse-transcriptase Pcrmentioning
confidence: 99%
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“…Both MR and glucocorticoid receptors (GR) are found in the brain. MR is found primarily in the limbic areas, such as the hippocampus, whereas the GR is more widely expressed [48].…”
Section: Mineralocorticoids and Neuronsmentioning
confidence: 99%
“…Thus, it has been suggested that the adaptive function of the HPA axis is critically dependent on glucocorticoid feedback mechanisms to dampen the stressor-induced activation of the HPA axis and to shut off further glucocorticoid secretion (Jacobson and Sapolsky, 1991). The MR is found only in the brain and in epithelial cells of the kidney, the colon, and exocrine glands (Kretz et al, 2001) (Reul et al, 2000).…”
Section: Corticosteroid Receptorsmentioning
confidence: 99%