The Brain Renin-Angiotensin System and Behavior

Moore, Norman C.; Gershon, Samuel

doi:10.1159/000107147

Cited by 7 publications

(3 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Over recent years, interest in the renin-angiotensin system in the brain has increased (see Moore and Gershon 1990) and a number of studies have focused on the influence of this system in cognition. Administration of inhibitors of angiotensin converting enzyme (ACE), such as captopril, SQ29852 and Hoe 288, have been reported to enhance performance in a number of cognitive tasks (Usinger et al 1988;Costall et al 1989).…”

mentioning

confidence: 99%

Attenuation of scopolamine-induced spatial memory deficits in the rat by cholinomimetic and non-cholinomimetic drugs using a novel task in the 12-arm radial maze

Dennes¹,

Barnes²

1993

Psychopharmacology

View full text Add to dashboard Cite

The effects of cholinomimetic and non-cholinomimetic agents on spatial memory using a novel task in the 12-arm radial maze were investigated. The task was designed to reduce the tendency to use non-spatial strategies. Animals were repeatedly trained to retrieve food rewards from three arms, until a criterion level of performance was reached. Scopolamine (0.03 and 0.1 mg/kg SC), but not N-methylscopolamine (0.1 mg/kg SC) disrupted performance of this task. Physostigmine (0.3 mg/kg SC) and pilocarpine (30 mg/kg SC) completely reversed the deficit of performance produced by scopolamine. Furthermore, the ACE inhibitor Hoe 288 (10 nmol ICV) and the angiotensin AT1 receptor antagonist losartan (10 mg/kg SC) also significantly attenuated the scopolamine-induced deficit. These results show that this novel task in the radial maze is sensitive to the disruptive effects of scopolamine and can identify cognitive enhancing effects of both cholinomimetic and non-cholinomimetic drugs. Thus, this maze task provides a useful model for the evaluation of novel cognitive enhancing agents.

show abstract

mentioning

confidence: 99%

Attenuation of scopolamine-induced spatial memory deficits in the rat by cholinomimetic and non-cholinomimetic drugs using a novel task in the 12-arm radial maze

Dennes¹,

Barnes²

1993

Psychopharmacology

View full text Add to dashboard Cite

show abstract

“…A II in the CNS stimulates drinking, causes a centrally mediated vasopressor response and releases hormones such as vasopressin, ACTH, oxytocin, prolactin and luteinizing hormone [11][12][13][14][15], The contribution of an overactive brain RAS to the hypertensive state was pos tulated [11,16], A II concentrations in several brain regions are higher in spontaneously hypertensive rats than in normal rats [6, I 7], It is also known that inhibi tors of the A II-generating converting enzyme given into the ventricles decrease blood pressure in hypertensive rats [ 18]. A II receptors are localized in the rat hypothal amus, locus ceruleus [19] and solitary-vagal area of the brain stem [20] indicating a direct effect on both norad renergic and cholinergic systems.…”

Section: Introductionmentioning

confidence: 99%

“…Besides its function as a vasopressor peptide A II influences memory and dis rupts the retention of passive avoidance tasks in rats [21,22]. Today A II is considered a neuromodulator in the brain, which is involved in several brain functions [15].…”

Section: Introductionmentioning

confidence: 99%

Angiotensin II Immunoreactivity in the Human Striatum and Hippocampus of Elderly Controls and Patients with Senile Dementia of the Alzheimer Type and Multi-Infarct Dementia

Savaskan

Höchli

Ganten

et al. 1991

Dement Geriatr Cogn Disord

View full text Add to dashboard Cite

The distribution of angiotensin II (A II) immunoreactivity in the postmortem human corpus striatum was studied in control cases and in patients with senile dementia of the Alzheimer type (SDAT) and multi-infarct dementia (MID). Additionally A II immunoreactivity was examined in the hippocampus of control and SDAT patients. A II-immunopositive cellular structures found in the striatum were the large neurons and vesiculated fibers in the globus pallidus (GP), especially in the dorsal parts, and some aspiny neurons in the putamen. Changes in the cell morphology marked the neurons in the GP of SDAT patients. In the MID cases only a few A II-immunopositive fibers and no cell somata were present in the GP. An extracellular, perivascular A II-staining pattern, which was found only in 1 control case, was common to all SDAT and MID patients. A II-immunopositive cellular structures found in the hippocampus included distorted neuronal processes and vesiculated fibers, which were partly coexisting with neuritic plaques as shown by the double labeling with thioflavin. The perivascular A II staining was also observed in the hippocampus, which was more predominant in SDAT cases. The definition of these two A II-immunopositive cell types in human corpus striatum suggests that A II may be involved in local neuronal or projection pathways. Possibly A II participates in the development of cerebrovascular pathologies in elderly control and demented brains.

show abstract

Platelet-activating factor and the cytokine network in inflammatory processes

Bonavida

Mencia‐Huerta²

1995

Clinical Reviews in Allergy

View full text Add to dashboard Cite

The Brain Renin-Angiotensin System and Behavior

Cited by 7 publications

References 35 publications

Attenuation of scopolamine-induced spatial memory deficits in the rat by cholinomimetic and non-cholinomimetic drugs using a novel task in the 12-arm radial maze

Attenuation of scopolamine-induced spatial memory deficits in the rat by cholinomimetic and non-cholinomimetic drugs using a novel task in the 12-arm radial maze

Angiotensin II Immunoreactivity in the Human Striatum and Hippocampus of Elderly Controls and Patients with Senile Dementia of the Alzheimer Type and Multi-Infarct Dementia

Platelet-activating factor and the cytokine network in inflammatory processes

Contact Info

Product

Resources

About