DOI: 10.1159/000409947
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The Brain Renin Angiotensin System in Central Cardiovascular Control

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“…The present work shows that the CNS Ang II–Aldosterone–MR modulatory pathway up-regulates circulating EO and thereby stimulates downstream arterial myocyte mechanisms already known to raise vascular tone and long-term BP [43] . Brain Ang II plays important roles in thirst, fluid and electrolyte homeostasis and long term BP regulation [44] . In addition, aldosterone is synthesized in the brain [45] [48] and is stimulated by Ang II.…”
Section: Discussionmentioning
confidence: 99%
“…The present work shows that the CNS Ang II–Aldosterone–MR modulatory pathway up-regulates circulating EO and thereby stimulates downstream arterial myocyte mechanisms already known to raise vascular tone and long-term BP [43] . Brain Ang II plays important roles in thirst, fluid and electrolyte homeostasis and long term BP regulation [44] . In addition, aldosterone is synthesized in the brain [45] [48] and is stimulated by Ang II.…”
Section: Discussionmentioning
confidence: 99%