The brain structure and function abnormalities of migraineurs: A systematic review and neuroimaging meta-analysis

Chen, Zhuhong; Cui, Yuling; Sun, Jing-Ting; Li, Yuting; Zhang, Chi; Zhang, Yangming; Li, Ze‐Yang; Shang, Yu‐Xuan; Ni, Min-Hua; Hu, Bo; Yan, Lin‐Feng; Wang, Wen

doi:10.3389/fneur.2022.1022793

Cited by 10 publications

(7 citation statements)

References 60 publications

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“…One review by Chen et al (2022) describes how performing additional studies and analyzing more existing literature may also help us better understand how specific migraine subtypes lead to certain structural changes on MRI. 51 There is also a lack of published literature on the role of small vessel changes including CMB, WMH and PVS in migraine; The limited studies that do exist on these topics are over a decade old and may not be reflective of current findings due to rapid advancements and dramatic improvements in imaging technology in recent years. Utilization of more updated imaging technology, such as ultra-high-field 7T MRI, could give us insight into structural brain changes that was inaccessible in the recent past.…”

Section: Discussionmentioning

confidence: 99%

Structural MRI in Migraine: A Review of Migraine Vascular and Structural Changes in Brain Parenchyma

Barisano²,

Phung

et al. 2023

J Cent Nerv Syst Dis

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Migraine is a complex and common disorder that affects patients around the world. Despite recent advances in this field, the exact pathophysiology of migraine is still not completely understood. Structural MRI sequences have revealed a variety of changes to brain parenchyma associated with migraine, including white matter lesions, volume changes, and iron deposition. This Review highlights different structural imaging findings in various types of migraine and their relationship to migraine characteristics and subtypes in order to improve our understanding of migraine, its pathophysiologic mechanisms, and how to better diagnose and treat it.

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Section: Discussionmentioning

confidence: 99%

Structural MRI in Migraine: A Review of Migraine Vascular and Structural Changes in Brain Parenchyma

Barisano²,

Phung

et al. 2023

J Cent Nerv Syst Dis

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“…Previous researchers have used the S100B protein and NSE as markers to try to understand whether nerve damage is present in migraine but have had conflicting results [ 7 – 9 ]. Recent studies have identified changes in grey matter volume and white matter abnormalities in migraine patients by magnetic resonance imaging (MRI) [ 26 – 28 ]. In multiple sclerosis and multiple system atrophy (MSA), it has been shown that there is a strong correlation between NfL levels and MRI analysis results [ 29 , 30 ].…”

Section: Discussionmentioning

confidence: 99%

Serum neurofilament light chain levels in migraine patients: a monocentric case–control study in China

Fang,

Wu,

Zhang

et al. 2023

J Headache Pain

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Purpose Serum neurofilament light chain (sNfL) can reflect nerve damage. Whether migraine can cause neurological damage remain unclear. This study assesses sNfL levels in migraine patients and explores whether there is nerve damage in migraine. Methods A case–control study was conducted in Xiamen, China. A total of 138 migraine patients and 70 healthy controls were recruited. sNfL (pg/mL) was measured on the single-molecule array platform. Univariate, Pearson correlation and linear regression analysis were used to assess the relationship between migraine and sNfL levels, with further subgroup analysis by migraine characteristics. Results Overall, 85.10% of the 208 subjects were female, with a median age of 36 years. sNfL levels were higher in the migraine group than in the control group (4.85 (3.49, 6.62) vs. 4.11 (3.22, 5.59)), but the difference was not significant (P = 0.133). The two groups showed an almost consistent trend in which sNfL levels increased significantly with age. Subgroup analysis showed a significant increase in sNfL levels in patients with a migraine course ≥ 10 years (β = 0.693 (0.168, 1.220), P = 0.010). Regression analysis results show that age and migraine course are independent risk factors for elevated sNfL levels, and there is an interaction between the two factors. Patients aged < 45 years and with a migraine course ≥ 10 years have significantly increased sNfL levels. Conclusions This is the first study to evaluate sNfL levels in migraine patients. The sNfL levels significantly increased in patients with a migraine course ≥ 10 years. More attention to nerve damage in young patients with a long course of migraine is required.

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“…In our study, the VBM analysis did not reveal any significant structural impairment. The presence of GMV alterations in migraine patients has been a topic of discussion in the literature, with studies and meta-analyses yielding heterogeneous results ( Wang et al, 2020 ; Masson et al, 2021 ; Chen et al, 2022a ; Zhang et al, 2023 ). Some researchers argue that there are no significant changes in brain structure in migraine patients ( Wang et al, 2020 ; Masson et al, 2021 ), which is consistent with our findings.…”

Section: Discussionmentioning

confidence: 99%

Impairments to the multisensory integration brain regions during migraine chronification: correlation with the vestibular dysfunction

Fan

et al. 2023

Front. Mol. Neurosci.

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ObjectivesMigraine is often combined with vestibular dysfunction, particularly in patients with chronic migraine (CM). However, the pathogenesis of migraine chronification leading to vestibular dysfunction is not fully understood. The current study investigated whether structural or functional impairments to the brain during migraine chronification could be associated with vestibular dysfunction development.MethodsThe eligible participants underwent clinical assessment and magnetic resonance imaging (MRI) scans. Voxel-based morphometry (VBM) determined structural impairment by evaluating alterations in gray matter volume (GMV). Functional impairment was assessed by the mean amplitude of low-frequency fluctuation (mALFF). Furthermore, the resting-state functional connectivity (rsFC) of regions possessing impairment was examined with a seed-based approach. We also analyzed the correlations between altered neuroimaging features with clinical variables and performed multiple linear regression.ResultsEighteen CM patients, 18 episodic migraine (EM) patients, and 18 healthy controls (HCs) were included in this study. A one-way ANOVA indicated the group differences in mALFF. These were located within right supramarginal gyrus (SMG), left angular gyrus (AG), middle frontal gyrus (MFG), left middle occipital gyrus (MOG), right rolandic operculum (Rol) and left superior parietal gyrus (SPG). During rsFC analysis, the CM group had more enhanced rsFC of left SPG with left MOG than the EM and HC groups. The EM group revealed enhanced rsFC of left SPG with left AG than the CM and HC groups. In multiple linear regression, after controlling for age, body mass index (BMI) and disease duration, the rsFC of left SPG with left MOG (β = 48.896, p = 0.021) was found to predict the total Dizziness Handicap Inventory (DHI) score with an explained variance of 25.1%. Moreover, the rsFC of left SPG with left MOG (β = 1.253, p = 0.003) and right SMG (β = −1.571, p = 0.049) were significant predictors of migraine frequency, accounting for a total explained variance of 73.8%.ConclusionThe functional impairments due to migraine chronification are primarily concentrated in the multisensory integration-related brain regions. Additionally, the rsFC of SPG with MOG can predict the frequency of migraine and the degree of vestibular dysfunction. Therefore, these neuroimaging features could be potential mechanisms and therapeutic targets for developing vestibular dysfunction in migraine.

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The brain structure and function abnormalities of migraineurs: A systematic review and neuroimaging meta-analysis

Cited by 10 publications

References 60 publications

Structural MRI in Migraine: A Review of Migraine Vascular and Structural Changes in Brain Parenchyma

Structural MRI in Migraine: A Review of Migraine Vascular and Structural Changes in Brain Parenchyma

Serum neurofilament light chain levels in migraine patients: a monocentric case–control study in China

Impairments to the multisensory integration brain regions during migraine chronification: correlation with the vestibular dysfunction

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